Explanipedia

Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT) Open

Xinyi Yuan, Jian Yin, Chang Liu, Xudong Chen, Meiying Chen , et al. · 2025

Creatine plays a vital role in cellular energy production and adenosine triphosphate (ATP) homeostasis and has also been identified as a neurotransmitter in the mammalian brain. Creatine is transported into cells by the human creatine tran…

Natural peptidoglycan nanoparticles enable rapid antigen purification and potent delivery of plant-derived vaccines Open

Shi‐Jian Song, Hai‐Ping Diao, Sensen Zhang, Sumin Kang, Chang Liu , et al. · 2025

Distinct epidemiological patterns and hematological biomarkers differentiate influenza A and B in adults: a diagnostic model from Shanghai (2023–2024) Open

W.P. Sun, Yichen Meng, Ting Zhang, Sensen Zhang, Lin Zhou · 2025

Integrating Large Language Models and Möbius Group Transformations for Temporal Knowledge Graph Embedding on the Riemann Sphere Open

Sensen Zhang, Xun Liang, Simin Niu, Zhendong Niu, Bo Wu , et al. · 2025

The significance of Temporal Knowledge Graphs (TKGs) in Artificial Intelligence (AI) lies in their capacity to incorporate time-dimensional information, support complex reasoning and prediction, optimize decision-making processes, enhance …

An improved fluorescein diacetate–propidium iodide staining system for assessing microspore and pollen viability at different developmental stages Open

Jianian Tang, Qiyu Luo, Huali Li, Zichen Wu, Zhansheng Lin , et al. · 2025

Immunosuppressant-free photosensitivity rescue of mnu-injured mice using human photoreceptor-like cells induced by rapid chemical reprogramming of fibroblasts as an intermediate stage Open

Zhe Xu, Yuan Liang, Sensen Zhang, Yuanyue Liu, Sen-Ning Liu , et al. · 2025

Structural basis for the reaction cycle and transport mechanism of human Na <sup>+</sup> -sulfate cotransporter NaS1 (SLC13A1) Open

Xudong Chen, Youqi Zhang, Jian Yin, Chang Liu, Min Xie , et al. · 2024

Sulfate (SO 4 2− ) is a pivotal inorganic anion with essential roles in mammalian physiology. NaS1, a member of solute carrier 13 family and divalent anion/sodium symporter family, functions as a Na + -sulfate cotransporter, facilitating s…

Molecular architecture of the mammalian 2-oxoglutarate dehydrogenase complex Open

Yitang Zhang, Maofei Chen, Xudong Chen, Minghui Zhang, Jian Yin , et al. · 2024

Risk hotspots and influencing factors identification of heavy metal(loid)s in agricultural soils using spatial bivariate analysis and random forest Open

Xiaohang Xu, Zhidong Xu, Longchao Liang, Jialiang Han, Gaoen Wu , et al. · 2024

Heavy metal(loid)s (HMs) in agricultural soils not only affect soil function and crop security, but also pose health risks to residents. However, previous concerns have typically focused on only one aspect, neglecting the other. This lack …

Clinical Features and a Prediction Model for Early Prediction of Composite Outcome in Chlamydia psittaci Pneumonia: A Multi-Centre Retrospective Study in China Open

Xue Yang, Man Wu, Tangzhiming Li, Jie Yu, Tian Fu , et al. · 2024

This study constructs a refined nomogram model for predicting the composite outcome in C. psittaci pneumonia patients. This nomogram model enables early and accurate C. psittaci pneumonia patients' evaluation, which may improve clinical ou…

Molecular architecture of mammalian pyruvate dehydrogenase complex Open

Maofei Chen, Yutong Song, Sensen Zhang, Yitang Zhang, Xu‐Dong Chen , et al. · 2024

Zeaxanthin dipalmitate-enriched wolfberry extract improves vision in a mouse model of photoreceptor degeneration Open

Xiong-Min Chen, Sensen Zhang, Lili Yang, Qihang Kong, Wenhua Zhang , et al. · 2024

Zeaxanthin dipalmitate (ZD) is a chemical extracted from wolfberry that protects degenerated photoreceptors in mouse retina. However, the pure ZD is expensive and hard to produce. In this study, we developed a method to enrich ZD from wolf…

Biomedical Knowledge Graph Embedding with Householder Projection (Student Abstract) Open

Sensen Zhang, Xun Liang, Simin Niu, Xuan Zhang, Feng Chen , et al. · 2024

Researchers have applied knowledge graph embedding (KGE) techniques with advanced neural network techniques, such as capsule networks, for predicting drug-drug interactions (DDIs) and achieved remarkable results. However, most ignore molec…

Characterization of sensory and motor dysfunction and morphological alterations in late stages of type 2 diabetic mice Open

Ting Tian, Haofeng Li, Sensen Zhang, Maojun Yang · 2024

Diabetic neuropathy is the most common complication of diabetes and lacks effective treatments. Although sensory dysfunction during the early stages of diabetes has been extensively studied in various animal models, the functional and morp…

Experimental Study on Remediation of Lead-Contaminated Soil with Citric Acid as Cleaning Agent Open

Huang YeHao, Yehao Huang, Runbo Gao, Xueqin Xu, Sensen Zhang , et al. · 2024

Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2) Open

Jingbo Yi, Boya Qi, Jian Yin, Ruochong Li, Xudong Chen , et al. · 2023

Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling Open

Xudong Chen, Min Xie, Sensen Zhang, Marta Tortajada, Jian Yin , et al. · 2023

A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity Open

Andras Boeszoermenyi, Léa Bernaleau, Xu‐Dong Chen, Felix Kartnig, Min Xie , et al. · 2023

Molecular basis of ClC-6 function and its impairment in human disease Open

Bing Zhang, Sensen Zhang, Maya M. Polovitskaya, Jingbo Yi, Binglu Ye , et al. · 2023

ClC-6 is a late endosomal voltage-gated chloride-proton exchanger that is predominantly expressed in the nervous system. Mutated forms of ClC-6 are associated with severe neurological disease. However, the mechanistic role of ClC-6 in norm…

Experimental Study on Remediation of Lead-contaminated Soil With Citric Acid as Cleaning Agent Open

Yehao Huang, Runbo Gao, Jingmin Sun, Sensen Zhang, Zipei Jia , et al. · 2023

Soil washing is a rapid and efficient method for heavy metals removal. In this study, in order to prove the feasibility of leaching remediation technology for remediation of lead-contaminated soil around a smelter, intermittent oscillating…

Clinical features and a prediction model for early prediction of composite outcome in Chlamydia psittaci pneumonia: a multi-centre retrospective study in China Open

Xue Yang, Man Wu, Tangzhiming Li, Jie Yu, Tian Fu , et al. · 2023

Introduction: There has been growing concern about Chlamydia psittaci (C. psittaci ) pneumonia in recent years. C.psittaci pneumonia has atypical clinical manifestations and often ignored by clinicians. This study analyzed the clinical cha…

Recent progress and challenges in the treatment of spinal cord injury Open

Ting Tian, Sensen Zhang, Maojun Yang · 2023

Spinal cord injury (SCI) disrupts the structural and functional connectivity between the higher center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction with a variety of complications. The pathophysiology …

Rice OsUBR7 modulates plant height by regulating histone H2B monoubiquitination and cell proliferation Open

Yangyi Zheng, Sensen Zhang, Yanqiu Luo, Fuquan Li, Jiantao Tan , et al. · 2022

Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2 Open

Xudong Chen, Mingze Zhou, Sensen Zhang, Jian Yin, Ping Zhang , et al. · 2021

Molecular insights into the human ABCB6 transporter Open

Guangyuan Song, Sensen Zhang, Mengqi Tian, Laixing Zhang, Runyu Guo , et al. · 2021

ABCB6 plays a crucial role in energy-dependent porphyrin transport, drug resistance, toxic metal resistance, porphyrin biosynthesis, protection against stress, and encoding a blood group system Langereis antigen. However, the mechanism und…

Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages Open

Mengrong Zhang, Liting Zhong, Xiu Han, Guoyin Xiong, Di Xu , et al. · 2021

One of the major challenges in treating Alzheimer's disease (AD) is its early diagnosis. Increasing data from clinical and animal research indicate that the retina may facilitate an early diagnosis of AD. However, a previous study on the 5…

Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis Open

Sensen Zhang, Baolei Yuan, Jordy Homing Lam, Jun Zhou, Xuan Zhou , et al. · 2021

Pannexin1 (PANX1) is a large-pore ATP efflux channel with a broad distribution, which allows the exchange of molecules and ions smaller than 1 kDa between the cytoplasm and extracellular space. In this study, we show that in human macropha…

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2 Open

Sensen Zhang, Jun Zhou, Yuebin Zhang, Tianya Liu, Perrine Friedel , et al. · 2021

Variable-Exponent Taper Equation Based on Multilevel Nonlinear Mixed Effect for Chinese Fir in China Open

Sensen Zhang, Jianjun Sun, Aiguo Duan, Jianguo Zhang · 2021

A variable-exponent taper equation was developed for Chinese fir (Cunninghamia lanceolate (Lamb.) Hook.) trees grown in southern China. Thirty taper equations from different groups of models (single, segmented, or variable-exponent taper e…

Molecular insights into the human CLC-7/Ostm1 transporter Open

Sensen Zhang, Yang Liu, Bing Zhang, Jun Zhou, Tianyu Li , et al. · 2020

Structural and functional studies of the human CLC-7/Ostm1 transporter help understand the slow gating of CLC proteins.

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