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View article: Multiple cis-regulatory elements collaborate to control <i>mdka</i> expression in telencephalic neural stem of adult zebrafish during constitutive and regenerative neurogenesis
Multiple cis-regulatory elements collaborate to control <i>mdka</i> expression in telencephalic neural stem of adult zebrafish during constitutive and regenerative neurogenesis Open
Zebrafish is a powerful animal model for studying nervous system regeneration due to its remarkable regenerative abilities and the availability of diverse molecular tools. After telencephalic brain injury, neural stem cells (NSCs) in the v…
View article: Zebrafish as a model organism in One Health Toxicology: Impact of solvents and exposure routes on the toxicity of platinum anticancer drugs
Zebrafish as a model organism in One Health Toxicology: Impact of solvents and exposure routes on the toxicity of platinum anticancer drugs Open
Zebrafish are widely used not only as a model in ecotoxicology but also to study the potential impact of chemicals on human health. Typically, zebrafish are exposed to chemicals dissolved in egg water or other defined media, which is the s…
View article: Gene expression patterns of the LDL receptor and its inhibitor Pcsk9 in the adult zebrafish brain suggest a possible role in neurogenesis
Gene expression patterns of the LDL receptor and its inhibitor Pcsk9 in the adult zebrafish brain suggest a possible role in neurogenesis Open
The low‐density lipoprotein receptor (LDLr) is the first member of a closely related transmembrane protein family. It is known for its involvement in various physiological processes, mainly in the regulation of lipid metabolism, especially…
View article: Mapping the cellular expression patterns of vascular endothelial growth factor aa and bb genes and their receptors in the adult zebrafish brain during constitutive and regenerative neurogenesis
Mapping the cellular expression patterns of vascular endothelial growth factor aa and bb genes and their receptors in the adult zebrafish brain during constitutive and regenerative neurogenesis Open
View article: Comparative insight into the regenerative mechanisms of the adult brain in zebrafish and mouse: highlighting the importance of the immune system and inflammation in successful regeneration
Comparative insight into the regenerative mechanisms of the adult brain in zebrafish and mouse: highlighting the importance of the immune system and inflammation in successful regeneration Open
Regeneration, the complex process of restoring damaged or absent cells, tissues, and organs, varies considerably between species. The zebrafish is a remarkable model organism for its impressive regenerative abilities, particularly in organ…
View article: Mapping the cellular expression patterns of vascular endothelial growth factor aa and bb genes and their receptors in the adult zebrafish brain during constitutive and regenerative neurogenesis
Mapping the cellular expression patterns of vascular endothelial growth factor aa and bb genes and their receptors in the adult zebrafish brain during constitutive and regenerative neurogenesis Open
The complex interplay between vascular signaling and neurogenesis in the adult brain remains a subject of intense research. By exploiting the unique advantages of the zebrafish model, in particular the persistent activity of neural stem ce…
View article: A comparative metabolomic investigation of different sections of Sicilian <i>Citrus x limon</i> (L.) Osbeck, characterization of bioactive metabolites, and evaluation of in vivo toxicity on zebrafish embryo
A comparative metabolomic investigation of different sections of Sicilian <i>Citrus x limon</i> (L.) Osbeck, characterization of bioactive metabolites, and evaluation of in vivo toxicity on zebrafish embryo Open
Citrus fruits are a diverse and economically important group of fruit crops known for their distinctive flavors and high nutritional value. Their cultivation and consumption contribute significantly to the global agricultural economy and o…
View article: Reversible Influence of Hemipiperazine Photochromism on the Early Development of Zebrafish Embryo
Reversible Influence of Hemipiperazine Photochromism on the Early Development of Zebrafish Embryo Open
This study explores the potential of controlling organismal development with light by using reversible photomodulation of activity in bioactive compounds. Specifically, our research focuses on plinabulin 1 , an inhibitor of tubulin dynamic…
View article: Caveolae disassemble upon membrane lesioning and foster cell survival
Caveolae disassemble upon membrane lesioning and foster cell survival Open
Repair of lesions in the plasma membrane is key to sustaining cellular homeostasis. Cells maintain cytoplasmic as well as membrane-bound stores of repair proteins that can rapidly precipitate at the site of membrane lesions. However, littl…
View article: Insulin signaling promotes neurogenesis in the brain of adult zebrafish
Insulin signaling promotes neurogenesis in the brain of adult zebrafish Open
Insulin is a peptide hormone that plays a central role in the regulation of circulating blood glucose in vertebrates, including zebrafish. Increasing evidence has demonstrated the important role of insulin in many brain functions. In zebra…
View article: Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord
Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord Open
The vertebrate nervous system is composed of a wide range of neurons and complex synaptic connections, raising the intriguing question of how neuronal diversity is generated. The spinal cord provides an excellent model for exploring the me…
View article: sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons
sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons Open
Sox transcription factors are crucial for vertebrate nervous system development. In zebrafish embryo, sox1 genes are expressed in neural progenitor cells and neurons of ventral spinal cord. Our recent study revealed that the loss of…
View article: Smuggling on the Nanoscale—Fusogenic Liposomes Enable Efficient RNA-Transfer with Negligible Immune Response In Vitro and In Vivo
Smuggling on the Nanoscale—Fusogenic Liposomes Enable Efficient RNA-Transfer with Negligible Immune Response In Vitro and In Vivo Open
The efficient and biocompatible transfer of nucleic acids into mammalian cells for research applications or medical purposes is a long-standing, challenging task. Viral transduction is the most efficient transfer system, but often entails …
View article: Temporal single-cell transcriptomic analysis of the<i>sox1a:eGFP</i>transgenic line identified the lateral floor plate progenitor cells as the origin of intraspinal serotonergic neurons
Temporal single-cell transcriptomic analysis of the<i>sox1a:eGFP</i>transgenic line identified the lateral floor plate progenitor cells as the origin of intraspinal serotonergic neurons Open
The Sox family of transcription factors plays a crucial role in the development of the vertebrate nervous system. In the zebrafish embryo, sox1 genes are expressed in neural progenitor cells and neurons of the ventral spinal cord. We recen…
View article: Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders
Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders Open
Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate many pathways involved in various biological mechanisms, in…
View article: Temporal Single-Cell Transcriptomic Analysis of the <i>sox1a:eGFP</i> Transgenic Line Identified the Lateral Floor Plate Progenitor Cells as the Origin of Intraspinal Serotonergic Neurons
Temporal Single-Cell Transcriptomic Analysis of the <i>sox1a:eGFP</i> Transgenic Line Identified the Lateral Floor Plate Progenitor Cells as the Origin of Intraspinal Serotonergic Neurons Open
View article: Phenotypic Discovery of Triazolo[1,5-<i>c</i>]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype
Phenotypic Discovery of Triazolo[1,5-<i>c</i>]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype Open
Phenotypic drug discovery (PDD) continues to fuel the research and development pipelines with first-in-class therapeutic modalities, but success rates critically depend on the quality of the underlying model system. Here, we employed a ste…
View article: Distribution of microglia/immune cells in the brain of adult zebrafish in homeostatic and regenerative conditions: Focus on oxidative stress during brain repair
Distribution of microglia/immune cells in the brain of adult zebrafish in homeostatic and regenerative conditions: Focus on oxidative stress during brain repair Open
Microglia are macrophage‐like cells exerting determinant roles in neuroinflammatory and oxidative stress processes during brain regeneration. We used zebrafish as a model of brain plasticity and repair. First, by performing L‐plastin (Lcp1…
View article: Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements
Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements Open
View article: mdka Expression Is Associated with Quiescent Neural Stem Cells during Constitutive and Reactive Neurogenesis in the Adult Zebrafish Telencephalon
mdka Expression Is Associated with Quiescent Neural Stem Cells during Constitutive and Reactive Neurogenesis in the Adult Zebrafish Telencephalon Open
In contrast to mammals, adult zebrafish display an extraordinary capacity to heal injuries and repair damage in the central nervous system. Pivotal for the regenerative capacity of the zebrafish brain at adult stages is the precise control…
View article: Two plus one is almost three: a fast approximation for multi-view deconvolution
Two plus one is almost three: a fast approximation for multi-view deconvolution Open
Multi-view deconvolution is a powerful image-processing tool for light sheet fluorescence microscopy, providing isotropic resolution and enhancing the image content. However, performing these calculations on large datasets is computational…
View article: A Homozygous Missense Variant in <scp><i>PPP1R1B/DARPP‐32</i></scp> Is Associated With Generalized Complex Dystonia
A Homozygous Missense Variant in <span><i>PPP1R1B/DARPP‐32</i></span> Is Associated With Generalized Complex Dystonia Open
Background The dystonias are a heterogeneous group of hyperkinetic disorders characterized by sustained or intermittent muscle contractions that cause abnormal movements and/or postures. Although more than 200 causal genes are known, many …
View article: Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos
Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos Open
High throughput imaging is used to assess hatching, lethality and malformations in zebrafish embryos and is suitable for hazard ranking of different nanomaterials.
View article: Neuron-Radial Glial Cell Communication via BMP/Id1 Signaling Is Key to Long-Term Maintenance of the Regenerative Capacity of the Adult Zebrafish Telencephalon
Neuron-Radial Glial Cell Communication via BMP/Id1 Signaling Is Key to Long-Term Maintenance of the Regenerative Capacity of the Adult Zebrafish Telencephalon Open
The central nervous system of adult zebrafish displays an extraordinary neurogenic and regenerative capacity. In the zebrafish adult brain, this regenerative capacity relies on neural stem cells (NSCs) and the careful management of the NSC…
View article: Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish
Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish Open
Zebrafish, a popular model for embryonic development and for modelling human diseases, has so far lacked a systematic functional annotation programme akin to those in other animal models. To address this, we formed the international DANIO-…
View article: In Vivo Behavior of the Antibacterial Peptide Cyclo[RRRWFW], Explored Using a 3-Hydroxychromone-Derived Fluorescent Amino Acid
In Vivo Behavior of the Antibacterial Peptide Cyclo[RRRWFW], Explored Using a 3-Hydroxychromone-Derived Fluorescent Amino Acid Open
Labeling biomolecules with fluorescent labels is an established tool for structural, biochemical, and biophysical studies; however, it remains underused for small peptides. In this work, an amino acid bearing a 3-hydroxychromone fluorophor…
View article: Neuron-radial glial cell communication via BMP/Id1 signaling maintains the regenerative capacity of the adult zebrafish telencephalon
Neuron-radial glial cell communication via BMP/Id1 signaling maintains the regenerative capacity of the adult zebrafish telencephalon Open
The mechanisms of the management of the neural stem cell (NSC) pool underlying the regenerative capacity of the adult zebrafish brain are not understood. We show that Bone Morphogenetic Proteins (BMPs) which are exclusively expressed by ne…
View article: Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury
Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury Open
Zebrafish is an attractive model to investigate regeneration of the nervous system. Despite major progress in our understanding of the underlying processes, the transcriptomic changes are largely unknown. We carried out a computational ana…
View article: HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors
HDL biodistribution and brain receptors in zebrafish, using HDLs as vectors for targeting endothelial cells and neural progenitors Open
View article: Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury
Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury Open
Adult neurogenesis is an evolutionary conserved process occurring in all vertebrates. However, striking differences are observed between the taxa, considering the number of neurogenic niches, the neural stem cell (NSC) identity, and brain …