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View article: (013) Mitochondrial Transplantation in Cavernous Nerve Injury Rat Model Improves Erectile Function
(013) Mitochondrial Transplantation in Cavernous Nerve Injury Rat Model Improves Erectile Function Open
Introduction Radical prostatectomy (RP) is one of the most common therapies for prostate cancer treatment. Unfortunately, most of the RP operations end up with erectile dysfunction (ED) due to cavernous nerve damage. Recently it is discove…
View article: (010) Mitochondrial Transplantation Improves Spermiogram and Histopathologic Results in a Torsion/Detorsion Model in Rats
(010) Mitochondrial Transplantation Improves Spermiogram and Histopathologic Results in a Torsion/Detorsion Model in Rats Open
Introduction Testicular torsion is the condition that the testicle twists around the spermatic cord, preventing arterial and venous blood flow, resulting with ischemia and necrosis. Objective In this study, we aimed to evaluate mitochondri…
(192) Effects of Statins on Human Corpus Cavernosum Tissue Open
Introduction Hydroxymethylglutaryl-CoA reductase inhibitors, known as statins, are commonly used for hypercholesterolemia treatment among with diet. Although it is established that statins aid in the recovery of erectile dysfunction by enh…
(114) Effects of Dapagliflozin on Human Corpus Cavernosum Tissue Open
Introduction Dapagliflozin (DAPA), a sodium glucose co-transporter 2 inhibitor, is an oral antidiabetic medication. Although effects of long-term DAPA treatment is well known for diabetes related ED, no research has conducted for influence…
(001) The Potential Ameliorative Effect of the Sodium-Glucose Co-transporter (SGLT-2) Inhibitor Dapagliflozin on Erectile Dysfunction in Type 2 Diabetic Rats Open
Introduction Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disease that results in microvascular and macrovascular complications. Sodium-Glucose Co-Transporter inhibitors (SGLT2i) block the main glucose transporter SGLT2 on the l…
An updated narrative review on revolutionizing erectile dysfunction treatment: the crucial role of trophic factors in Adipose-Derived stem cell therapy Open
Erectile dysfunction (ED) is a pervasive condition projected to affect some 322 million men worldwide by 2025, profoundly impairing quality of life and psychosocial well‑being. Current therapies-most notably phosphodiesterase‑5 inhibitors …
THE EFFECT OF A HIGH FRUCTOSE DIET ON ERECTILE FUNCTION IN BILATERAL CAVERNOUS NERVE INJURY RAT MODEL Open
Objectives Metabolic syndrome (MetS) is a cluster of many risk factors, such as insulin resistance, elevated blood glucose levels, and hypertension. In addition, excessive consumption of fructose is likely to increase the risk of developin…
PROTECTIVE EFFECTS OF INTRACAVERNOSAL BOTULINUM TOXIN TYPE A THERAPY ON PENILE STRUCTURE AND ERECTILE FUNCTION IN A RAT MODEL OF BILATERAL CAVERNOUS NERVE INJURY Open
Objectives After radical prostatectomy (RP), erectile dysfunction (ED) is common, primarily due to iatrogenic cavernous nerve injury. This study aimed to evaluate the effects and mechanisms of intracavernosal (i.c.) onabotulinum toxin A (B…
The Impact of Levothyroxine and Testosterone Administration on Bladder Contractility in the Rat Model of Propylthiouracil-Induced Hypothyroidism Open
The authors' research suggests that hypothyroidism may affect the contractility and morphology of the bladder. In males with hypothyroidism and urogenital system dysfunction, combination therapy with thyroid hormones and T has a major impa…
(247) A Rat Model for Bipolar Androgen Therapy is Evaluated for Its Effects on Erectile Dysfunction after Castration Open
Introduction Prostate cancer (PCa), an androgen-dependent tumor and one of the most prevalent cancers in males, has traditionally been treated with androgen suppression. In recent years, bipolar androgen treatment (BAT) has emerged as a po…
Ameliorative effect of cranberry on erectile function in diabetic rats Open
Background and Aims: Cranberry products are beneficial in erectile dysfunction (ED). Therefore, we assessed the impact of Cranberry fruit extract (Cranberry-E) on in vivo erectile response and in vitro relaxant responses in the corpus cave…
Combined levothyroxine and testosterone treatment for restoring erectile dysfunction in propylthiouracil-induced hypothyroid rats Open
Background Sexual dysfunction may indicate severe endocrine diseases. Recent research has suggested a link between hypothyroidism, low testosterone (T) levels, and erectile dysfunction (ED); however, the exact cause is unknown. Aim We soug…
Co-administration of sodium hydrosulfide and tadalafil modulates hypoxia and oxidative stress on bladder dysfunction in a rat model of bladder outlet obstruction Open
Combination therapy has beneficial effects on bladder dysfunction via regulating both H2S and nitric oxide pathways as well as downregulation of oxidative stress and hypoxia. The synergistic effect of H2S and nitric oxide is likely to modu…
İNTRAKAVERNOSAL SİLDENAFİLİN SIÇANLARDA DUTASTERID TEDAVİSİ SONRASI GELİŞEN EREKTIL DİSFONKSİYON ÜZERİNE YARARLI ETKİSİ Open
Objective: Benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) are the most common illnesses in aged male patients. 5α-reductase inhibitors (5-ARIs) are suggested for the treatment of BPH. Furthermore, the association of 5ARIs…
Cytotoxic and Apoptotic Effects of the Combination of Borax (Sodium Tetraborate) and 5-Fluorouracil on DLD-1 Human Colorectal Adenocarcinoma Cell Line Open
Our current findings suggest that the combination of borax with 5-FU has a strong cytotoxic and apoptotic effect on the human CRC DLD-1 cells.
Analysis of Changes in Serum Levels and Gene Expression Profiles of Novel Adipocytokines (Omentin, Vaspin, Irisin and Visfatin) and Their Correlation with Serum C-reactive Protein Levels in Women Diagnosed with Endometriosis Open
Increased levels of serum irisin and decreased visfatin and vaspin gene expressions in blood may be considered as a potential biomarker in endometriosis. The identification of new adipocytokines, which demonstrate an alteration in the pres…
Testosterone positively regulates functional responses and nitric oxide expression in the isolated human corpus cavernosum Open
Background Testosterone (T) deficiency is associated with erectile dysfunction (ED). The relaxant response of T on the corporal smooth muscle through a non‐genomic pathway has been reported; however, the in vitro modulating effects of T on…
The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts Open
Introduction Cardiometabolic syndrome (CMS), as a bunch of metabolic disorders mainly characterized by type 2 diabetes mellitus (T2DM), hypertension, atherosclerosis, central adiposity, and abdominal obesity triggering androgen deficiency,…
Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum Open
Cinnamomum cassia (Cinnamon) is a well-known traditional medicine with therapeutic benefits for centuries. We evaluated the effects of cinnamon essential oil (CEO) and its main component cinnamaldehyde (CA) on human corpus cavernosum (HCC)…
Effect of Extracts of the Aerial Parts and Roots from Four <i>Ferulago</i> Species on Erectile Dysfunction in Rats with Streptozotocin-Induced Diabetes Open
These species can be utilized in erectile dysfunction and may be an herbal alternative to synthetic drugs.
PD28-01 COLLAGENASE CLOSTRIDIUM HISTOLYTICUM POTENTIATES ACETYLCHOLINE-INDUCED RELAXATION AND INHIBITS SYMPATHETIC NEUROGENIC CONTRACTILE RESPONSES IN ISOLATED HUMAN CORPUS CAVERNOSUM Open
You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy II (PD28)1 Apr 2019PD28-01 COLLAGENASE CLOSTRIDIUM HISTOLYTICUM POTENTIATES ACETYLCHOLINE-INDUCED RELAXATION AND INHIBITS SYMPATHETIC NE…
MP06-19 THE COMBINATION TREATMENT WITH SODIUM HYDROSULFIDE AND TADALAFIL RESTORES BLADDER FUNCTION IN A RAT MODEL OF PARTIAL BLADDER OUTLET OBSTRUCTION VIA MODULATION OF HYDROGEN SULFIDE/NITRIC OXIDE PATHWAY Open
You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research & Pathophysiology (MP06)1 Apr 2019MP06-19 THE COMBINATION TREATMENT WITH SODIUM HYDROSULFIDE AND TADALAFIL RESTORES BLADDER FUNCTION IN A RAT MODEL OF PARTIAL BL…
Effect of Aerial part and Root Extracts from Ferulago mughlae Pe?men and Ferulago sandrasica Pe?men Quézel Growing in Turkey on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats Open
Ferulago species have been utilised since ancient times as antihelmentic, peptic, sedative and aphrodisiac, and as the seasoning in view of their special odors.In Turkish traditional medicine, the roots from some members of this genus are …
Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum Open
Cinnamomum cassia (Cinnamon) is a well-known traditional medicine with therapeutic benefits for centuries. We evaluated the effects of cinnamon essential oil (CEO) and its main component cinnamaldehyde (CA) on human corpus cavernosum (HCC)…
Effect of aerial part and root extracts from Ferula orientalis L. growing in Turkey on erectile dysfunction in streptozotocin-ınduced diabetic rats Open
Caralluma tuberculata çok yıllık bir bitkidir. Pakistan'ın en çok dağlık bölgelerinde bulunan Asclepiadaceae familyasına aittir. Bitki pişmiş halde, çay olarak tüketilmiş veya kuru toz halinde veya taze çiğnenmiş olarak kullanılır. Çok büy…
Effect of Aerial Parts and Root Extracts from Four Ferulago Species on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats Open
Objectives:The extracts of Ferulago species are used as an aphrodisiacs in Turkey so we aimed to demonstrate in vivo and in vitro the relaxant effect of four Ferulago species extracts on corpus cavernosum (CC). Materials and Methods: A tot…
MP85-18 IVABRADINE (FIRST HCN CHANNEL BLOCKER) ATTENUATES HUMAN CORPUS CAVERNOSUM CONTRACTION IN VITRO VIA INTERFERENCE WITH THE CALCIUM AND POTASSIUM TRANSFER: A POTENTIAL NEW THERAPEUTIC OPTION FOR ERECTILE DYSFUNCTION Open
You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy II1 Apr 2018MP85-18 IVABRADINE (FIRST HCN CHANNEL BLOCKER) ATTENUATES HUMAN CORPUS CAVERNOSUM CONTRACTION IN VITRO VIA INTERFERENCE WITH…
MP85-19 EUGONADAL TESTOSTERONE LEVELS POSITIVELY REGULATES ERECTILE FUNCTION IN ISOLATED HUMAN CORPUS CAVERNOSUM Open
You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy II1 Apr 2018MP85-19 EUGONADAL TESTOSTERONE LEVELS POSITIVELY REGULATES ERECTILE FUNCTION IN ISOLATED HUMAN CORPUS CAVERNOSUM Laith Alzwe…