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View article: Efficacy and safety of osivelotor in participants with sickle cell disease in a 12-week phase 2, multicenter, open-label, dose-finding trial and extension study
Efficacy and safety of osivelotor in participants with sickle cell disease in a 12-week phase 2, multicenter, open-label, dose-finding trial and extension study Open
Background: Osivelotor is a sickle hemoglobin (HbS) polymerization inhibitor being investigated as a potential treatment for sickle cell disease (SCD), and promising results have been reported previously for preliminary analysis from a pha…
View article: Identification of Breastfeeding Problems and the Effect of Educational Breastfeeding Support on the Breastfeeding Success
Identification of Breastfeeding Problems and the Effect of Educational Breastfeeding Support on the Breastfeeding Success Open
Aim: The identification of breastfeeding problems in the postpartum period and the effect of interventions on these problems. Materials and Methods: This was a retrospective and cross-sectional study. This study included mothers who had an…
View article: A Phase 1b, Open-label, Multiple-Dose Study Evaluating Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Pociredir in Patients With Sickle Cell Disease (SCD): Trial Design
A Phase 1b, Open-label, Multiple-Dose Study Evaluating Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Pociredir in Patients With Sickle Cell Disease (SCD): Trial Design Open
Background SCD is the most common inherited blood disorder caused by a mutation in the β - globin (HBB) gene, resulting in dysfunctional hemoglobin S (HbS) that polymerizes under hypoxic conditions with consequent characteristic and pathog…
View article: A rare cause of unimproved respiratory distress syndrome in a preterm infant: congenital hypothyroidism
A rare cause of unimproved respiratory distress syndrome in a preterm infant: congenital hypothyroidism Open
The findings of respiratory distress syndrome (RDS) and thyroid dysfunction of prematurity have a bidirectional relationship. Here we discuss the regression of RDS findings in a preterm infant with congenital hypothyroidism with hypothyroi…
View article: OP-037 Evaluation of postnatal corticosteroid use in the prevention of bronchopulmonary dysplasia in premature infants by lung ultrasonography
OP-037 Evaluation of postnatal corticosteroid use in the prevention of bronchopulmonary dysplasia in premature infants by lung ultrasonography Open
Aim Bronchopulmonary dysplasia (BPD) is a chronic lung disease that is more common in premature newborns and occurs with the addition of triggering mechanisms such as mechanical ventilation and oxygen exposure during the intensive care per…
View article: Differences in Possible Risk Factors, Treatment Strategies, and Outcomes of Neonatal Pneumothorax in Preterm and Term Infants
Differences in Possible Risk Factors, Treatment Strategies, and Outcomes of Neonatal Pneumothorax in Preterm and Term Infants Open
Exposure to DR resuscitation and the need for surfactant are the most common risk factors for NP in preterm infants. Although oxygen and/or needle aspiration treatments are less invasive in symptomatic NP, the improvement rate without CDI …
View article: The diagnostic value of pulmonary near‐infrared spectroscopy in the early distinction of neonatal pneumonia from transient tachypnea of the newborn
The diagnostic value of pulmonary near‐infrared spectroscopy in the early distinction of neonatal pneumonia from transient tachypnea of the newborn Open
Aim Pulmonary near‐infrared spectroscopy (NIRS) is a new and promising tool for diagnosis of neonatal respiratory diseases (RD). The study aimed to determine the role of pulmonary regional oxygen saturation (pRSO 2 ) values obtained by NIR…
View article: The diagnostic value of pulmonary near-infrared spectroscopy in the early distinction of neonatal pneumonia from transient tachypnea of the newborn*
The diagnostic value of pulmonary near-infrared spectroscopy in the early distinction of neonatal pneumonia from transient tachypnea of the newborn* Open
Aim: Pulmonary near-infrared spectroscopy (NIRS) is a new and promising tool for diagnosis of neonatal respiratory diseases (RD). The study aimed to determine the role of pulmonary regional oxygen saturation (pRSO ) values obtained by NIRS…
View article: Life-threatening massive upper gastrointestinal bleeding in a term and healthy baby
Life-threatening massive upper gastrointestinal bleeding in a term and healthy baby Open
Upper gastrointestinal (UGI) bleeding due to gastric ulcer and gastritis can be seen in severely ill or premature infants but is rarely reported in healthy term newborns. UGI endoscopy is crucial for the etiological evaluation and appropri…
View article: A newborn case of split choroid plexus supposed to have intraventricular hemorrhage by bedside cranial ultrasound
A newborn case of split choroid plexus supposed to have intraventricular hemorrhage by bedside cranial ultrasound Open
Cranial ultrasound is a valuable bedside technique and procedure of choice to image the intraventricular hemorrhage (IVH). Moreover, anatomical variants of the neonatal brain should be known to avoid of misinterpretation. The term of split…
View article: Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?
Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants? Open
Purpose: The reason for gastrointestinal system (GIS) motility problems in premature infants is multifactorial and intestinal immaturity is the most important contributing factor. To investigate the effect of epidural (EA) or general anest…
View article: Health care-associated infection surveillance: A prospective study of a tertiary neonatal intensive care unit
Health care-associated infection surveillance: A prospective study of a tertiary neonatal intensive care unit Open
Introduction: Health care-associated infection (HCAI) is a serious problem of neonatal intensive care units (NICUs) which is related to morbidity, mortality and increased cost of medical care. This study aimed to determine the incidence of…
View article: Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant
Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant Open
Histopathological findings of the placentas from preterm deliveries provided important data in determining the etiology of preterm delivery and outcomes of infants. Infants delivered by mothers with chorioamnionitis were particularly found…
View article: Influence of platelet count, platelet mass index, and platelet function on the spontaneous closure of ductus arteriosus in the prematurity
Influence of platelet count, platelet mass index, and platelet function on the spontaneous closure of ductus arteriosus in the prematurity Open
This is the first study in the English literature providing evidence of the influence of platelet dysfunction on the spontaneous closure of ductus arteriosus in prematurity. Longer collagen-ADP duration is identified as a risk factor of du…
View article: Respiratory Distress and Management Strategies in the Newborn
Respiratory Distress and Management Strategies in the Newborn Open
Approximately 10% of neonates require respiratory support immediately after delivery due to transitional problems or respiratory disorders, and up to 1% of neonates are in need of resuscitation. Respiratory distress is the most frequent ca…
View article: Transient tachypnea of the newborn: are there bedside clues for predicting the need of ventilation support?
Transient tachypnea of the newborn: are there bedside clues for predicting the need of ventilation support? Open
Decision making to transfer a late preterm or term neonate with the diagnosis of transient tachypnea of the newborn (TTN) to an intensive care unit for respiratory support is a challenge for caregivers in level one and two NICUs. The aim o…