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View article: Multi-centre discovery and validation study evaluating breath biomarkers for the diagnosis of lung cancer – the LuCID study
Multi-centre discovery and validation study evaluating breath biomarkers for the diagnosis of lung cancer – the LuCID study Open
Background Volatile Organic Compound (VOC) research for lung cancer detection has faced study design and analytical methodology challenges limiting translation into clinical practice. We evaluated the diagnostic value of breath biomarkers …
View article: Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma Open
Background Cellular plasticity, involving loss of lineage determination and emergence of hybrid cell states, plays a pivotal role in non-small cell lung cancer (NSCLC) disease progression and therapy resistance. However, the full spectrum …
View article: Linoleoyl-lysophosphatidylcholine suppresses immune-related adverse events due to immune checkpoint blockade
Linoleoyl-lysophosphatidylcholine suppresses immune-related adverse events due to immune checkpoint blockade Open
Immune related adverse events (irAEs) after immune checkpoint blockade (ICB) therapy occur in a significant proportion of cancer patients. To date, the circulating mediators of ICB-irAEs remain poorly understood. Using non-targeted mass sp…
View article: Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy
Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy Open
Introduction Immune checkpoint blockade (ICB) therapy has been revolutionary in its ability to treat advanced malignancies. Yet many patients receiving ICB develop Immune related adverse events (IRAEs), a leading cause for patients to disc…
View article: JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells
JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells Open
Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer immunotherapy target in mice, its potential to cause toxicity, specific mode of action wit…
View article: Single-cell immune profiling reveals long-term changes in myeloid cells and identifies a novel subset of CD9+ monocytes associated with COVID-19 hospitalization
Single-cell immune profiling reveals long-term changes in myeloid cells and identifies a novel subset of CD9+ monocytes associated with COVID-19 hospitalization Open
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in severe immune dysfunction, hospitalization, and death. Many patients also develop long-COVID-19, experiencin…
View article: Tumor-infiltrating NK cell subsets associated with the magnitude of T cell response in human lung cancer
Tumor-infiltrating NK cell subsets associated with the magnitude of T cell response in human lung cancer Open
NK cells are the predominant innate lymphocyte subset that contribute to anti-tumor immunity. The molecular profile of human tumor-infiltrating NK cells, and particularly, their characteristics in relation to CD8 + cytotoxic T lymphocyte (…
View article: Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 <sup>+</sup> T cells
Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 <sup>+</sup> T cells Open
Fewer SARS-CoV-2–reactive memory CD8 + T cells with “exhaustion” features are present in patients with severe versus mild COVID-19.
View article: Interplay of Monocytes and T Lymphocytes in COVID-19 Severity
Interplay of Monocytes and T Lymphocytes in COVID-19 Severity Open
The COVID-19 pandemic represents an ongoing global crisis that has already impacted over 13 million people. The responses of specific immune cell populations to the disease remain poorly defined, which hinders improvements in treatment and…
View article: Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8<sub>+</sub>T cells
Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8<sub>+</sub>T cells Open
The molecular properties of CD8 + T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8 + T cells from 39 COVID-19 patients and 10 healthy subjects…
View article: M1<sup>hot</sup> tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer
M1<sup>hot</sup> tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer Open
Background The role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor’s anti-immunity stratagems, is controversial. Macrophages modulate their activi…
View article: Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4<sup>+</sup>T cells
Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4<sup>+</sup>T cells Open
The contribution of CD4 + T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic analysis of viral antigen-reactive CD4 + T cells from 32 COVID-…
View article: Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer
Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer Open
High numbers of tissue-resident memory T (TRM) cells are associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, …
View article: Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis
Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis Open
Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not def…
View article: Author response: Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis
Author response: Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Matrix stiffening with downst…