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View article: Structural Biomarkers Influencing Drusenoid Pigment Epithelial Detachment Lifecycle and the Development of Late Macular Degeneration
Structural Biomarkers Influencing Drusenoid Pigment Epithelial Detachment Lifecycle and the Development of Late Macular Degeneration Open
Purpose: Drusenoid pigment epithelial detachment (dPED) is a notable phenotype in age-related macular degeneration (AMD), often evolving into macular complications such as macular neovascularization (MNV) and geographic atrophy (GA). The a…
View article: Optogenetics: A Novel Therapeutic Avenue for Age-Related Macular Degeneration
Optogenetics: A Novel Therapeutic Avenue for Age-Related Macular Degeneration Open
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly, characterized by progressive degeneration of the retinal pigment epithelium (RPE) and photoreceptors in the macula. Current treatment opt…
View article: Retinal Vessel Coronal Displacement in Intermediate Age-Related Macular Degeneration
Retinal Vessel Coronal Displacement in Intermediate Age-Related Macular Degeneration Open
Introduction: This pilot study aimed to test the feasibility of a novel vectorial image analysis method to quantify coronal microvascular displacement in different retinal plexuses in intermediate age-related macular degeneration (iAMD) ov…
View article: Progression Patterns in Foveal-Sparing Geographic Atrophy With Double-Layer Sign Due to Neovascularization or Basal Laminar Deposits
Progression Patterns in Foveal-Sparing Geographic Atrophy With Double-Layer Sign Due to Neovascularization or Basal Laminar Deposits Open
OCTA has provided valuable insights into the pathogenic interpretation of the DLS signature. Our findings confirm that a neovascular DLS protects the retinal pigment epithelium and outer retina, contributing to prolonged foveal preservatio…
View article: Targeting Senescence, Oxidative Stress, and Inflammation: Quercetin-Based Strategies for Ocular Diseases in Older Adults
Targeting Senescence, Oxidative Stress, and Inflammation: Quercetin-Based Strategies for Ocular Diseases in Older Adults Open
Quercetin, a flavonol abundant in fruits and vegetables, has attracted significant attention for its senotherapeutic effects, which involve the selective elimination of senescent cells and the modulation of pro-inflammatory phenotypes that…
View article: YAG LASER-ASSISTED FRAGMENTATION OF DEXAMETHASONE IMPLANTS IN THE ANTERIOR CHAMBER
YAG LASER-ASSISTED FRAGMENTATION OF DEXAMETHASONE IMPLANTS IN THE ANTERIOR CHAMBER Open
Purpose: To report efficacy on the use of neodymium Yag laser in fragmenting dexamethasone intravitreal implant (Ozurdex, Allergan, Inc, Irvine, CA) migrated in the anterior chamber (AC). Methods: Multicenter, retrospective, interventional…
View article: Sphingolipidoses and Retinal Involvement: A Comprehensive Review
Sphingolipidoses and Retinal Involvement: A Comprehensive Review Open
Sphingolipidoses are a class of inherited lysosomal storage diseases, characterized by enzymatic deficiencies that impair sphingolipid degradation. This enzymatic malfunction results in the pathological accumulation of sphingolipids within…
View article: Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration
Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration Open
Optical coherence tomography (OCT) has emerged as a pivotal imaging modality in elucidating the pathogenic, clinical, and prognostic implications of age-related macular degeneration (AMD). This review examines the utility of OCT in providi…
View article: Metabolic, Microvascular, and Structural Predictors of Long-Term Functional Changes Evaluated by Multifocal Electroretinogram in Type 1 Diabetes
Metabolic, Microvascular, and Structural Predictors of Long-Term Functional Changes Evaluated by Multifocal Electroretinogram in Type 1 Diabetes Open
Background: This study aimed to analyze the potential pathogenic connection between metabolic factors, photoreceptor cell rearrangements, retinal microvascular perfusion, and functional parameters through multifocal electroretinography (mf…
View article: Leveraging Optical Coherence Tomography and Angiography Artifacts to Identify Clinicopathological Correlates in Macular Disorders
Leveraging Optical Coherence Tomography and Angiography Artifacts to Identify Clinicopathological Correlates in Macular Disorders Open
Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) are pivotal imaging techniques in diagnosing and managing macular disorders, providing high-resolution cross-sectional images of the retina. Although OC…
View article: Exploring Current Molecular Targets in the Treatment of Neovascular Age-Related Macular Degeneration toward the Perspective of Long-Term Agents
Exploring Current Molecular Targets in the Treatment of Neovascular Age-Related Macular Degeneration toward the Perspective of Long-Term Agents Open
Long-lasting anti-vascular endothelial growth factor (anti-VEGF) agents have become an option to reduce treatment frequency, with ongoing research exploring optimal responses and safety profiles. This review delves into molecular targets, …
View article: Posterior Polar Annular Choroidal Dystrophy: Genetic Insights and Differential Diagnosis in Inherited Retinal Diseases
Posterior Polar Annular Choroidal Dystrophy: Genetic Insights and Differential Diagnosis in Inherited Retinal Diseases Open
Posterior polar annular choroidal dystrophy (PPACD) is a rare ocular disorder and presents as symmetric degeneration of the retinal pigment epithelium (RPE) and the underlying choriocapillaris, encircling the retinal vascular arcades and o…
View article: Idiopathic Intracranial Hypertension Papillopathy due to Hormonal Changes during Pregnancy
Idiopathic Intracranial Hypertension Papillopathy due to Hormonal Changes during Pregnancy Open
Background. The underlying mechanisms of papilledema associated with intracranial hypertension remain unclear. A case of bilateral papillary edema in a patient with chronic idiopathic intracranial hypertension who was asymptomatic during h…
View article: The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy
The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy Open
Diabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear…
View article: Progression Biomarkers of Microvascular and Photoreceptor Changes Upon Long-Term Evaluation in Type 1 Diabetes
Progression Biomarkers of Microvascular and Photoreceptor Changes Upon Long-Term Evaluation in Type 1 Diabetes Open
This study demonstrated an initial vasodilatory phenomenon resulting from a compensatory mechanism from the superficial vasculature, followed by capillary dropout. Initially, it would seem that there was an adaptive response by the DCP to …
View article: The Role of Alpha-Synuclein Deposits in Parkinson’s Disease: A Focus on the Human Retina
The Role of Alpha-Synuclein Deposits in Parkinson’s Disease: A Focus on the Human Retina Open
Parkinson’s disease (PD) is a neurodegenerative condition characterized by the progressive deterioration of dopaminergic neurons in the central and peripheral autonomous system and the intraneuronal cytoplasmic accumulation of misfolded α-…
View article: Prognostic Imaging Biomarkers in Diabetic Macular Edema Eyes Treated with Intravitreal Dexamethasone Implant
Prognostic Imaging Biomarkers in Diabetic Macular Edema Eyes Treated with Intravitreal Dexamethasone Implant Open
Background: The aim was to evaluate predictive value of baseline optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in diabetic macular edema (DME) treated with dexamethasone implant (DEXi). Methods: OCT and OCTA para…
View article: Implementing Predictive Models in Artificial Intelligence through OCT Biomarkers for Age-Related Macular Degeneration
Implementing Predictive Models in Artificial Intelligence through OCT Biomarkers for Age-Related Macular Degeneration Open
Artificial intelligence (AI) represents a growing and promising branch of computer science that is expanding the horizon of prediction, screening, and disease monitoring. The use of multimodal imaging in retinal diseases is particularly ad…
View article: OCT and OCT Angiography Update: Clinical Application to Age-Related Macular Degeneration, Central Serous Chorioretinopathy, Macular Telangiectasia, and Diabetic Retinopathy
OCT and OCT Angiography Update: Clinical Application to Age-Related Macular Degeneration, Central Serous Chorioretinopathy, Macular Telangiectasia, and Diabetic Retinopathy Open
Similar to ultrasound adapting soundwaves to depict the inner structures and tissues, optical coherence tomography (OCT) utilizes low coherence light waves to assess characteristics in the eye. Compared to the previous gold standard diagno…
View article: Characteristics of intermediate age-related macular degeneration with hyperreflective foci
Characteristics of intermediate age-related macular degeneration with hyperreflective foci Open
View article: Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective
Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective Open
The contribution of choroidal vasculature to the pathogenesis of age-related macular degeneration (AMD) has been long debated. The present narrative review aims to discuss the primary molecular and choroidal structural changes occurring wi…
View article: Impact of Intravitreal Anti-VEGF Therapy on Microperimetry of the Retinal Nonperfusion Areas of Patients with Proliferative Diabetic Retinopathy
Impact of Intravitreal Anti-VEGF Therapy on Microperimetry of the Retinal Nonperfusion Areas of Patients with Proliferative Diabetic Retinopathy Open
An association between OCTA and MP-1 parameter changes was found. The concomitant functional and morphological improvement in half of the ROIs suggests that anti-VEGF treatment may promote retinal changes that result in a better functional…
View article: Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration
Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration Open
View article: In vivo assessment of associations between photoreceptors structure and macular perfusion in type 1 diabetes
In vivo assessment of associations between photoreceptors structure and macular perfusion in type 1 diabetes Open
Purpose To explore the potential relationships between macular vascular network and different adaptive optics (AO) metrics in patients with type 1 diabetes mellitus (DM1) with no signs (NoDR) or mild non-proliferative diabetic retinopathy …
View article: Vitamin A deficiency and the retinal “double carrot” sign with optical coherence tomography
Vitamin A deficiency and the retinal “double carrot” sign with optical coherence tomography Open
View article: Sub-retinal pigment epithelium tubules in non- neovascular age-related macular degeneration
Sub-retinal pigment epithelium tubules in non- neovascular age-related macular degeneration Open
Purpose To describe a novel optical coherence tomography (OCT) signature resembling sub-retinal pigment epithelium (RPE) tubules (SRT) in non-neovascular age-related macular degeneration (AMD). Methods Patients suffering from non-neovascul…
View article: Prognostic relevance of optical coherence tomography angiography biomarkers in diabetic macular edema
Prognostic relevance of optical coherence tomography angiography biomarkers in diabetic macular edema Open
was not mandatory. The review article was devoted to describe optical coherence tomography angiography (OCTA) biomarkers with a prognostic significance in predicting the evolution of diabetic macular edema (DME). OCTA features are crucial …
View article: The “Topography” of Glaucomatous Defect Using OCT and Visual Field Examination
The “Topography” of Glaucomatous Defect Using OCT and Visual Field Examination Open
de Paula A, Perdicchi A, Pocobelli A, et al. The "Topography" of Glaucomatous Defect Using OCT and Visual Field Examination. J Curr Glaucoma Pract 2022;16(1):31-35.
View article: Functional Correlates of Outer Retina Remodeling in Intermediate Age-Related Macular Degeneration Using Microperimetry
Functional Correlates of Outer Retina Remodeling in Intermediate Age-Related Macular Degeneration Using Microperimetry Open
Progressive degeneration of the ONL is related to irreversible photoreceptor dysfunction in iAMD. Likewise, choroidal vascular modifications are associated with a significant functional decline in the central region and diffusely.
View article: Understanding Neurodegeneration from a Clinical and Therapeutic Perspective in Early Diabetic Retinopathy
Understanding Neurodegeneration from a Clinical and Therapeutic Perspective in Early Diabetic Retinopathy Open
Recent evidence indicates that neurodegeneration is a critical element of diabetic retinopathy (DR) pathogenesis. The neuronal cells’ apoptosis contributes to microvascular impairment and blood–retinal barrier breakdown. Therefore, neurode…