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View article: <i>Lactobacillus iners</i> dominates the vaginal microbiota of healthy Italian women of reproductive age
<i>Lactobacillus iners</i> dominates the vaginal microbiota of healthy Italian women of reproductive age Open
Large sex hormonal fluctuations are thought to influence vaginal microbiota, but little is known about the impact of small, physiological variations. Here, we tracked changes in vaginal microbiota during four key menstrual cycle phases in …
View article: Aging in women – The microbiome perspective
Aging in women – The microbiome perspective Open
Menopause is a hallmark of women's aging and is frequently portrayed as a medical issue. It also encompasses social and biological aspects often neglected and not well-understood, leaving women with insufficient support and attention. With…
View article: Exploring sex-specific causal links between thousands of proteins and lipid metabolism using the UK Biobank Pharma proteomics data
Exploring sex-specific causal links between thousands of proteins and lipid metabolism using the UK Biobank Pharma proteomics data Open
Lipid traits are known to be sex-differential, but the underlying molecular players are largely unknown. Since protein levels are downstream products of gene expression, proteomics data can be crucial to understand etiology of sex-differen…
View article: Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking
Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking Open
View article: Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels
Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels Open
In the past 20 years, the involvement of gut microbiome in human health has received particular attention, but its contribution to age-related diseases remains unclear. To address this, we performed a comprehensive two-sample Mendelian Ran…
View article: <i>Lactobacillus iners</i> dominates the vaginal microbiota of healthy Italian women of reproductive age
<i>Lactobacillus iners</i> dominates the vaginal microbiota of healthy Italian women of reproductive age Open
Large sex hormonal fluctuations are thought to influence vaginal microbiota, but little is known about the impact of small, physiological variations. Here we tracked changes in vaginal microbiota during four key menstrual cycle phases in 6…
View article: A possible association between low MBL/lectin pathway functionality and microbiota dysbiosis in endometriosis patients
A possible association between low MBL/lectin pathway functionality and microbiota dysbiosis in endometriosis patients Open
View article: Microbiome-wide PheWAS links gut microbial SNVs to human health and exposures
Microbiome-wide PheWAS links gut microbial SNVs to human health and exposures Open
The importance of the gut microbiome in human health has been widely recognized, with alterations in species abundances now reported for many different diseases. In recent years, observations of within-species genetic diversity and strain-…
View article: Multi-ancestry polygenic risk scores for venous thromboembolism
Multi-ancestry polygenic risk scores for venous thromboembolism Open
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality, with large disparities in incidence rates between Black and White Americans. Polygenic risk scores (PRSs) limited to variants discovered in genome-wide a…
View article: Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content
Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content Open
Genetic susceptibility to metabolic associated fatty liver disease (MAFLD) is complex and poorly characterized. Accurate characterization of the genetic background of hepatic fat content would provide insights into disease etiology and cau…
View article: The Women4Health cohort: a unique cohort to study women-specific mechanisms of cardio-metabolic regulation
The Women4Health cohort: a unique cohort to study women-specific mechanisms of cardio-metabolic regulation Open
Aims Epidemiological research has shown relevant differences between sexes in clinical manifestations, severity, and progression of cardiovascular and metabolic disorders. To date, the mechanisms underlying these differences remain unknown…
View article: Array comparative genomic hybridisation in a foetus with thoracic ectopia cordis: a case report
Array comparative genomic hybridisation in a foetus with thoracic ectopia cordis: a case report Open
Background. Ectopia cordis (EC) is a rare anomaly characterized by abnormal heart positioning. The exact aetiology remains unknown, is likely to be associated with genetic and environmental factors. The introduction of an array-based compa…
View article: Association of protein function-altering variants with cardiometabolic traits: the strong heart study
Association of protein function-altering variants with cardiometabolic traits: the strong heart study Open
Clinical and biomarker phenotypic associations for carriers of protein function-altering variants may help to elucidate gene function and health effects in populations. We genotyped 1127 Strong Heart Family Study participants for protein f…
View article: Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation
Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation Open
Primary open-angle glaucoma (POAG), a leading cause of irreversible blindness globally, shows disparity in prevalence and manifestations across ancestries. We perform meta-analysis across 15 biobanks (of the Global Biobank Meta-analysis In…
View article: Multi-ancestry polygenic risk scores for venous thromboembolism
Multi-ancestry polygenic risk scores for venous thromboembolism Open
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality, with large disparities in incidence rates between Black and White Americans. Polygenic risk scores (PRSs) limited to variants discovered in genome-wide a…
View article: Host genetic regulation of human gut microbial structural variation
Host genetic regulation of human gut microbial structural variation Open
Although the impact of host genetics on gut microbial diversity and the abundance of specific taxa is well established 1–6 , little is known about how host genetics regulates the genetic diversity of gut microorganisms. Here we conducted a…
View article: Rome III Criteria Capture Higher Irritable Bowel Syndrome SNP-Heritability and Highlight a Novel Genetic Link With Cardiovascular Traits
Rome III Criteria Capture Higher Irritable Bowel Syndrome SNP-Heritability and Highlight a Novel Genetic Link With Cardiovascular Traits Open
View article: Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization Open
Background Genome-wide association studies for glycemic traits have identified hundreds of loci associated with these biomarkers of glucose homeostasis. Despite this success, the challenge remains to link variant associations to genes, and…
View article: Mendelian randomisation shows diverticular disease and irritable bowel syndrome increase the risk of haemorrhoidal disease
Mendelian randomisation shows diverticular disease and irritable bowel syndrome increase the risk of haemorrhoidal disease Open
Recently in Gut, Zhu and colleagues1 investigated causality of genetic risk effects across three genetically correlated conditions: haemorrhoidal disease (HEM), diverticular disease (DIV) and IBS. Using genome-wide association study (GWAS)…
View article: Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers
Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers Open
View article: Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts Open
View article: Publisher Correction: Age-dependent sex differences in cardiometabolic risk factors
Publisher Correction: Age-dependent sex differences in cardiometabolic risk factors Open
Correction to: Nature Cardiovascular Research, published online 12 September 2022. In the version of this article initially published, Lude Franke, Jan A. Kuivenhoven, Alexandra Zhernakova and Jingyuan Fu were listed in the Lifelines Cohor…
View article: Age-dependent sex differences in cardiometabolic risk factors
Age-dependent sex differences in cardiometabolic risk factors Open
Cardiometabolic diseases (CMDs) are a major cause of mortality worldwide, yet men and women present remarkable differences in disease prognosis, onset and manifestation. Here we characterize how sex differences in cardiometabolic risk fact…
View article: Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project Open
View article: Association of protein function-altering variants with cardiometabolic traits: the strong heart study
Association of protein function-altering variants with cardiometabolic traits: the strong heart study Open
Clinical and biomarker phenotypic associations for carriers of protein function-altering variants may help to elucidate gene function and health effects in populations. We genotyped 1127 Strong Heart Family Study participants for protein f…
View article: Phenotypic and genetic factors are associated with absence of cardiomyopathy symptoms in PLN c.40_42delAGA carriers
Phenotypic and genetic factors are associated with absence of cardiomyopathy symptoms in PLN c.40_42delAGA carriers Open
The c.40_42delAGA variant in the phospholamban gene ( PLN ) has been associated with dilated and arrhythmogenic cardiomyopathy, with up to 70% of carriers experiencing a major cardiac event by age 70. However, other carriers remain asympto…
View article: Environmental factors shaping the gut microbiome in a Dutch population
Environmental factors shaping the gut microbiome in a Dutch population Open
View article: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project Open
View article: Challenges and future directions for studying effects of host genetics on the gut microbiome
Challenges and future directions for studying effects of host genetics on the gut microbiome Open
View article: Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation
Genome-wide association meta-analysis identifies novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation Open
Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness globally. There is disparity in POAG prevalence and manifestations across ancestries. We identify novel and unique genetics that underlie POAG risk in differen…