Serena Silvano
YOU?
Author Swipe
View article: RSPO1, a potent inducer of pancreatic β cell neogenesis
RSPO1, a potent inducer of pancreatic β cell neogenesis Open
Inducing the neogenesis of pancreatic insulin-producing β cells holds great promise for diabetes research. However, non-toxic compounds with such activities remain to be discovered. Herein, we report the identification of RSPO1, a key agon…
View article: Wnt Pathway in Pancreatic Development and Pathophysiology
Wnt Pathway in Pancreatic Development and Pathophysiology Open
The pancreas is an abdominal gland that serves 2 vital purposes: assist food processing by secreting digestive enzymes and regulate blood glucose levels by releasing endocrine hormones. During embryonic development, this gland originates f…
View article: Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression
Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression Open
Type 1 diabetes results from the autoimmune-mediated loss of insulin-producing beta-cells. Accordingly, important research efforts aim at regenerating these lost beta-cells by converting pre-existing endogenous cells. Following up on previ…
View article: Gfi1 Loss Protects against Two Models of Induced Diabetes
Gfi1 Loss Protects against Two Models of Induced Diabetes Open
Background: Although several approaches have revealed much about individual factors that regulate pancreatic development, we have yet to fully understand their complicated interplay during pancreas morphogenesis. Gfi1 is transcription fact…
View article: Epigenetic Control of Pancreatic Regeneration in Diabetes
Epigenetic Control of Pancreatic Regeneration in Diabetes Open
Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglyc…
View article: Role of ghrelin in pancreatic development and function
Role of ghrelin in pancreatic development and function Open
Ghrelin is a gastric peptide with anabolic functions. It acutely stimulates growth hormone (GH) secretion from the anterior pituitary glands and modulates hypothalamic circuits that control food intake and energy expenditure. Besides its c…
View article: Ectopic expression of <i>Pax4</i> in pancreatic δ cells results in β-like cell neogenesis
Ectopic expression of <i>Pax4</i> in pancreatic δ cells results in β-like cell neogenesis Open
The recent demonstration that pancreatic α cells can be continuously regenerated and converted into β-like cells upon ectopic expression of Pax4 opened new avenues of research in the endocrine cell differentiation and diabetes fields. To d…
View article: β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma”
β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma” Open
Type 1 diabetes is an auto-immune disease resulting in the loss of pancreatic β-cells and, consequently, in chronic hyperglycemia. Insulin supplementation allows diabetic patients to control their glycaemia quite efficiently, but treated p…
View article: Régénération des cellules β pancréatiques par l’activation de la voie de signalisation GABA
Régénération des cellules β pancréatiques par l’activation de la voie de signalisation GABA Open
International audience
View article: GABA signaling stimulates α-cell-mediated β-like cell neogenesis
GABA signaling stimulates α-cell-mediated β-like cell neogenesis Open
Diabetes is a chronic and progressing disease, the number of patients increasing exponentially, especially in industrialized countries. Regenerating lost insulin-producing cells would represent a promising therapeutic alternative for most …
View article: Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis
Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis Open