Serge A. T. Fobofou
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View article: Demystifying racemic natural products in the homochiral world
Demystifying racemic natural products in the homochiral world Open
View article: Bichromonol, a dimeric coumarin with anti-HIV activity from the stem bark of <i>Hypericum roeperianum</i>
Bichromonol, a dimeric coumarin with anti-HIV activity from the stem bark of <i>Hypericum roeperianum</i> Open
Infectious diseases caused by viruses like HIV and SARS-COV-2 (COVID-19) pose serious public health threats. In search for new antiviral small molecules from chemically underexplored Hypericum species, a previously undescribed atrop…
View article: Microbial metabolites: cause or consequence in gastrointestinal disease?
Microbial metabolites: cause or consequence in gastrointestinal disease? Open
Systems biology studies have established that changes in gastrointestinal microbiome composition and function can adversely impact host physiology. Notable diseases synonymously associated with dysbiosis include inflammatory bowel diseases…
View article: Computational Applications in Secondary Metabolite Discovery (CAiSMD): an online workshop
Computational Applications in Secondary Metabolite Discovery (CAiSMD): an online workshop Open
We report the major conclusions of the online open-access workshop “Computational Applications in Secondary Metabolite Discovery (CAiSMD)” that took place from 08 to 10 March 2021. Invited speakers from academia and industry and about 200 …
View article: Plant-Derived Compounds against Microbial Infections and Cancers
Plant-Derived Compounds against Microbial Infections and Cancers Open
Plants synthesize and preserve a variety of metabolites known as natural products. Many of them are easily extractable and can be used as starting material or chemical scaffolds for various purposes, especially in drug discovery. Numbers o…
View article: Hypericibacter terrae gen. nov., sp. nov. and Hypericibacter adhaerens sp. nov., two new members of the family Rhodospirillaceae isolated from the rhizosphere of Hypericum perforatum
Hypericibacter terrae gen. nov., sp. nov. and Hypericibacter adhaerens sp. nov., two new members of the family Rhodospirillaceae isolated from the rhizosphere of Hypericum perforatum Open
Two strains of the family Rhodospirillaceae were isolated from the rhizosphere of the medicinal plant Hypericum perforatum . Cells of both strains were Gram-stain-negative, motile by means of a single polar flagellum, non-spore-forming, no…
View article: In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines
In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines Open
Malignancies constitute a global health concern and chemotherapy remains the main mode of treatment. The present study was designed to evaluate the cytotoxicity of 8 compounds from Desbordesia glaucescens namely lanosta-7,24-dien-3-one (1)…
View article: Metabolomic analysis, isolation, characterization and synthesis of bioactive compounds from Hypericum species (Hypericaceae)
Metabolomic analysis, isolation, characterization and synthesis of bioactive compounds from Hypericum species (Hypericaceae) Open
Wie können wir neue bioaktive Naturstoffe aus komplexen Mischungen (z.B. Pflanzenextrakte) ohne vorherige Isolierung finden? Obwohl Naturstoffe eine reichhaltige Quelle für Arzneistoffe sind, wird ihre Entdeckung durch viele Herausforderun…