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Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death Open

François Virard, Stéphane Giraud, Mélanie Bonnet, Léa Magadoux, Laetitia B. B. Martin , et al. · 2024

Data from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

The discovery of a targeted therapeutic compound along with its companion predictive biomarker is a major goal of clinical development for a personalized anticancer therapy to date. Here we present evidence of the predictive value of TLR3 …

Supplementary Figure Legends 1-2, Table Legend and Methods from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

Supplementary Figure Legends 1-2, Table Legend and Methods from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Supplementary Figure 2 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

Supplementary Figure 2 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Supplementary Figure 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

Supplementary Figure 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Supplementary Figure Legends 1-2, Table Legend and Methods from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

Supplementary Figure Legends 1-2, Table Legend and Methods from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Supplementary Table 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

Supplementary Table 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Supplementary Table 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

Supplementary Table 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Data from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

The discovery of a targeted therapeutic compound along with its companion predictive biomarker is a major goal of clinical development for a personalized anticancer therapy to date. Here we present evidence of the predictive value of TLR3 …

Supplementary Figure 2 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

Supplementary Figure 2 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Supplementary Figure 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer Open

Bruno Salaun, Laurence Zitvogel, Carine Asselin‐Paturel, Yannis Morel, Karine Chemin , et al. · 2023

Supplementary Figure 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity Open

Helena Dragic, Audrey Barthelaix, Cédric Duret, Simon Le Goupil, Hadrien Laprade , et al. · 2022

The glucose-requiring hexosamine biosynthetic pathway (HBP), which produces UDP-N-acetylglucosamine for glycosylation reactions, promotes lung adenocarcinoma (LUAD) progression. However, lung tumor cells often reside in low-nutrient microe…

Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma Open

Marie-Anaïs Locquet, Gabriel Ichim, Joseph Bisaccia, Aurélie Dutour, Serge Lebecque , et al. · 2021

A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-Alpha Interaction Open

Rana El Sabeh, Mélanie Bonnet, Katy Le Corf, Kevin A. Lang, Alain Kfoury , et al. · 2021

Collectively, our results indicate that the formation of MyD88/methER-α complexes during inflammatory signaling and their disruption by estrogen may represent a mechanism that contributes to gender bias in inflammatory responses.

Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis Open

Marc Bonnin, Nadim Farés, Barbara Testoni, Yann Estornes, Kathrin Weber , et al. · 2019

Hepatocellular carcinoma (HCC) is a heterogeneous disease associated with a poor prognosis. In patients with HCC, TLR3 downregulation is associated with reduced survival. Herein, we show that the absence of TLR3 is associated with a lower …

Exome sequencing and pathogenicity-network analysis of five French families implicate mTOR signalling and autophagy in familial sarcoidosis Open

Alain Calender, Clarice X. Lim, Thomas Weichhart, Adrien Buisson, Valérie Besnard , et al. · 2019

International audience

Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis Open

Lugain Alkurdi, François Virard, Béatrice Vanbervliet, Kathrin Weber, Florent Toscano , et al. · 2018

Toll-like receptor 3 (TLR3) mediates innate immune responses by sensing viral dsRNA, but also induces apoptosis selectively in cancer cells. Our analysis by immunohistochemistry revealed that TLR3 is frequently overexpressed in 130 non-sma…

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis Open

Yann Estornes, Yves Dondelinger, Kathrin Weber, Inge Bruggeman, Adam Peall , et al. · 2018

The sensitivity of cells to death receptor-induced apoptosis is commonly controlled by multiple checkpoints in order to limit induction of excessive or unnecessary death. Although cytotoxic in various cancer cells, tumor necrosis factor (T…

Whole exome sequencing in three families segregating a pediatric case of sarcoidosis Open

Alain Calender, Pierre Antoine Rollat Farnier, Adrien Buisson, S. Pinson, Abderrazzak Bentaher , et al. · 2018

A Gender-Dependent Molecular Switch of Inflammation <i>via</i> MyD88/Estrogen Receptor-alpha Interaction Open

Rana El Sabeh, Mélanie Bonnet, Katy Le Corf, Kevin A. Lang, Alain Kfoury , et al. · 2018

Most Toll-like receptors and IL-1/IL-18 receptors activate a signaling cascade via the adaptor molecule MyD88, resulting in NF-κB activation and inflammatory cytokine and chemokine production. Females are less susceptible than males to inf…

Additional file 5: of Whole exome sequencing in three families segregating a pediatric case of sarcoidosis Open

Alain Calender, Pierre Rollat Farnier, Adrien Buisson, S. Pinson, Abderrazzak Bentaher , et al. · 2018

Table S4. Over-representation gene enrichment KEGG pathway analysis was performed on all the deleterious variant carrying genes. Data of the over-representation gene enrichment KEGG pathway analysis was performed on all the deleterious var…

Additional file 6: of Whole exome sequencing in three families segregating a pediatric case of sarcoidosis Open

Alain Calender, Pierre Rollat Farnier, Adrien Buisson, S. Pinson, Abderrazzak Bentaher , et al. · 2018

All recessive variants identified in cases T1, T2 and T3. The de novo dominant variants have been fully described in the manuscript. The datasets of cases T1, T2 and T3 extracted from VCF (Variant call Format) and extracted in XLS file. (X…

De la valériane au traitement du cancer : le succès d'un composé biosourcé Open

Malik Hamaïdia, Pierre-Yves Barez, Arnaud Carpentier, Serge Lebecque, Krystian Miazek , et al. · 2016

peer reviewed

Molecular dynamics study of micelles properties according to their size Open

Serge Lebecque, Jean‐Marc Crowet, Mehmet Nail Nasir, Magali Deleu, Laurence Lins · 2016

Familial vs. sporadic sarcoidosis: BTNL2 polymorphisms, clinical presentations, and outcomes in a French cohort Open

Yves Pachéco, Alain Calender, Dominique Israël‐Biet, Pascal Roy, Serge Lebecque , et al. · 2016

Despite a significant difference in BTNL2 polymorphism between sarcoid patients and controls, there was no such difference between familial and sporadic sarcoidosis cases and no correlation between BTNL2 polymorphism and disease severity o…

Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway Open

Cédric Chaveroux, Carmen Sarcinelli, Virginie Barbet, Sofiane Belfeki, Audray Barthelaix , et al. · 2016

The hexosamine biosynthetic pathway (HBP) is a nutrient-sensing metabolic pathway that produces the activated amino sugar UDP-N-acetylglucosamine, a critical substrate for protein glycosylation. Despite its biological significance, little …

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