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View article: Basal association of a transcription factor favors early gene expression
Basal association of a transcription factor favors early gene expression Open
Responses to extracellular signals via Mitogen-Activated Protein Kinase (MAPK) pathways control complex transcriptional programs where hundreds of genes are induced at a desired level with a specific timing. Gene expression regulation is l…
View article: Transcriptional heterogeneity shapes stress-adaptive responses in yeast
Transcriptional heterogeneity shapes stress-adaptive responses in yeast Open
View article: Basal association of a transcription factor favors early gene expression
Basal association of a transcription factor favors early gene expression Open
Responses to extracellular signals via Mitogen-Activated Protein Kinase (MAPK) pathways control complex transcriptional programs where hundreds of genes are induced at a desired level with a specific timing. Gene expression regulation is l…
View article: Adapting to ever-changing conditions
Adapting to ever-changing conditions Open
Experiments involving periodic stimuli shed light on the interplay between hyper-osmotic stress and glucose starvation in yeast cells.
View article: Implication of polymerase recycling for nascent transcript quantification by live cell imaging
Implication of polymerase recycling for nascent transcript quantification by live cell imaging Open
Transcription enables the production of RNA from a DNA template. Due to the highly dynamic nature of transcription, live‐cell imaging methods play a crucial role in measuring the kinetics of this process. For instance, transcriptional burs…
View article: Implication of polymerase recycling for nascent transcript quantification by live cell imaging
Implication of polymerase recycling for nascent transcript quantification by live cell imaging Open
Transcription enables the production of RNA from a DNA template. Due to the highly dynamic nature of transcription, live-cell imaging methods play a crucial role in measuring the kinetics of this process. For instance, transcriptional burs…
View article: Live cell microscopy: From image to insight
Live cell microscopy: From image to insight Open
Live-cell microscopy is a powerful tool that can reveal cellular behavior as well as the underlying molecular processes. A key advantage of microscopy is that by visualizing biological processes, it can provide direct insights. Nevertheles…
View article: Cellular heterogeneity: yeast-side story
Cellular heterogeneity: yeast-side story Open
A major challenge for cells lies in their ability to detect, respond and adapt to changing environments that may threaten their survival. Among the numerous evolutionary strategies, cell-to-cell heterogeneity allows the emergence of differ…
View article: Environmental connectivity controls diversity in soil microbial communities
Environmental connectivity controls diversity in soil microbial communities Open
View article: Cross‐regulation between CDK and MAPK control cellular fate
Cross‐regulation between CDK and MAPK control cellular fate Open
Background Commitment to a new cell cycle is controlled by a number of cellular signals. Mitogen‐activated protein kinase (MAPK) pathways, which transduce multiple extracellular cues, have been shown to be interconnected with the cell cycl…
View article: Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors
Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors Open
View article: Single-particle imaging of stress-promoters induction reveals the interplay between MAPK signaling, chromatin and transcription factors
Single-particle imaging of stress-promoters induction reveals the interplay between MAPK signaling, chromatin and transcription factors Open
View article: Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast
Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast Open
Budding yeast, Saccharomyces cerevisiae, has been widely used as a model system to study cellular signaling in response to internal and external cues. Yeast was among the first organisms in which the architecture, feedback mechanism…
View article: Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors
Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors Open
Mitogen-Activated Protein Kinases (MAPKs) control a wide array of cellular functions by transducing extracellular information into defined biological responses. In order to understand how these pathways are regulated, dynamic single cell m…
View article: Single-particle view of stress-promoters induction dynamics: an interplay between MAPK signaling, chromatin and transcription factors
Single-particle view of stress-promoters induction dynamics: an interplay between MAPK signaling, chromatin and transcription factors Open
Precise regulation of gene expression in response to environmental changes is crucial for cell survival, adaptation and proliferation. In eukaryotic cells, extracellular signal integration is often carried out by Mitogen-Activated Protein …
View article: Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5
Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5 Open
Cells continuously adapt cellular processes by integrating external and internal signals. In yeast, multiple stress signals regulate pheromone signaling to prevent mating under unfavorable conditions. However, the underlying crosstalk mech…
View article: Close-Range Interactions Favor Growth in Random-Paired Extracted Soil Bacteria
Close-Range Interactions Favor Growth in Random-Paired Extracted Soil Bacteria Open
Species interactions at the cellular level are thought to govern the formation and functioning of microbial communities, but direct measurements of species interactions are difficult to perform between the hundreds of different species tha…
View article: Corrigendum: Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability
Corrigendum: Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability Open
View article: Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability
Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability Open
In cells lacking telomerase, telomeres gradually shorten during each cell division to reach a critically short length, permanently activate the DNA damage checkpoint, and trigger replicative senescence. The increase in genome instability t…
View article: Timing of gene expression in a cell‐fate decision system
Timing of gene expression in a cell‐fate decision system Open
View article: Cross-regulation between CDK and MAPK control cellular fate
Cross-regulation between CDK and MAPK control cellular fate Open
Commitment to a new cell cycle is controlled by a number of cellular signals. Mitogen-Activated Protein Kinase pathways, which transduce multiple extracellular cues, have been shown to be interconnected with the cell cycle. Using budding y…
View article: Timing of gene expression in a cell-fate decision system
Timing of gene expression in a cell-fate decision system Open
During development, morphogens provide extracellular cues allowing cells to select a specific fate by inducing complex transcriptional programs. The mating pathway in budding yeast offers simplified settings to understand this process. Phe…
View article: Nuclear relocation of Kss1 contributes to the specificity of the mating response
Nuclear relocation of Kss1 contributes to the specificity of the mating response Open
View article: New families of single integration vectors and gene tagging plasmids for genetic manipulations in budding yeast
New families of single integration vectors and gene tagging plasmids for genetic manipulations in budding yeast Open
View article: Real-time quantification of protein expression at the single-cell level via dynamic protein synthesis translocation reporters
Real-time quantification of protein expression at the single-cell level via dynamic protein synthesis translocation reporters Open
View article: A Cellular System for Spatial Signal Decoding in Chemical Gradients
A Cellular System for Spatial Signal Decoding in Chemical Gradients Open
View article: Dynamic single cell measurements of kinase activity by synthetic kinase activity relocation sensors
Dynamic single cell measurements of kinase activity by synthetic kinase activity relocation sensors Open
View article: Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade
Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade Open
Hog1-dependent feedback inhibits the Sln1 branch by directly phosphorylating Ssk2 and components of the sensory module.