Sergey Shuvaev
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View article: Development of a fibrin-targeted theranostic for gastric cancer
Development of a fibrin-targeted theranostic for gastric cancer Open
Patients with advanced gastric cancer (GCa) have limited treatment options, and alternative treatment approaches are necessary to improve their clinical outcomes. Because fibrin is abundant in gastric tumors but not in healthy tissues, we …
View article: Simultaneous Positron Emission Tomography and Molecular Magnetic Resonance Imaging of Cardiopulmonary Fibrosis in a Mouse Model of Left Ventricular Dysfunction
Simultaneous Positron Emission Tomography and Molecular Magnetic Resonance Imaging of Cardiopulmonary Fibrosis in a Mouse Model of Left Ventricular Dysfunction Open
Background Aging‐associated left ventricular dysfunction promotes cardiopulmonary fibrogenic remodeling, Group 2 pulmonary hypertension (PH), and right ventricular failure. At the time of diagnosis, cardiac function has declined, and cardi…
View article: Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies
Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies Open
Pancreatic ductal adenocarcinoma (PDAC) is an invasive and rapidly progressive malignancy. A major challenge in patient management is the lack of a reliable imaging tool to monitor tumor response to treatment. Tumor-associated fibrosis cha…
View article: Simultaneous PET and molecular MR imaging of cardiopulmonary fibrosis in a mouse model of left ventricular dysfunction
Simultaneous PET and molecular MR imaging of cardiopulmonary fibrosis in a mouse model of left ventricular dysfunction Open
Background Aging-associated left ventricular (LV) dysfunction promotes cardiopulmonary fibrogenic remodeling, Group 2 pulmonary hypertension (PH), and right ventricular failure. At the time of diagnosis, cardiac function has declined, and …
View article: Detection of Pulmonary Fibrosis with a Collagen-Mimetic Peptide
Detection of Pulmonary Fibrosis with a Collagen-Mimetic Peptide Open
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology that is characterized by excessive deposition and abnormal remodeling of collagen. IPF has a mean survival time of only 2-5 years from diagnosis, creating a need to detec…
View article: Noninvasive Quantification of Radiation-Induced Lung Injury using a Targeted Molecular Imaging Probe
Noninvasive Quantification of Radiation-Induced Lung Injury using a Targeted Molecular Imaging Probe Open
Rationale Radiation-induced lung injury (RILI) is a progressive inflammatory process commonly seen following irradiation for lung cancer. The disease can be insidious, often characterized by acute pneumonitis followed by chronic fibrosis w…
View article: Biodistribution, Dosimetry, and Pharmacokinetics of<sup>68</sup>Ga-CBP8: A Type I Collagen–Targeted PET Probe
Biodistribution, Dosimetry, and Pharmacokinetics of<sup>68</sup>Ga-CBP8: A Type I Collagen–Targeted PET Probe Open
The 68Ga-Collagen Binding Probe #8, 68Ga-CBP8, is a peptide-based, type I collagen-targeted probe developed for imaging of tissue fibrosis. The aim of this study was to determine the biodistribution, dosimetry, and pharmacokinetics of 68Ga…
View article: Revisiting dithiadiaza macrocyclic chelators for copper-64 PET imaging
Revisiting dithiadiaza macrocyclic chelators for copper-64 PET imaging Open
Copper-64 complex with a new dithiadiaza macrocyclic chelator was evaluated as a PET tracer.
View article: Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation
Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation Open
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxi…
View article: A near-IR luminescent ratiometric ytterbium pH probe
A near-IR luminescent ratiometric ytterbium pH probe Open
The hypersensitive2F5/2to2F7/2transition of Yb3+can be used to monitor perturbations of the coordination sphere in ytterbium(iii) complexes.
View article: Monitoring of the ADP/ATP Ratio by Induced Circularly Polarised Europium Luminescence
Monitoring of the ADP/ATP Ratio by Induced Circularly Polarised Europium Luminescence Open
A series of three europium complexes bearing picolyl amine moieties was found to possess differing binding affinities towards Zn 2+ and three nucleotides: AMP, ADP, and ATP. A large increase in the total emission intensity was observed upo…
View article: Selective signalling of glyphosate in water using europium luminescence
Selective signalling of glyphosate in water using europium luminescence Open
Selective sensing of glyphosate in the micromolar regime in water.
View article: Chiral probes for α<sub>1</sub>-AGP reporting by species-specific induced circularly polarised luminescence
Chiral probes for α<sub>1</sub>-AGP reporting by species-specific induced circularly polarised luminescence Open
Luminescence spectroscopy has been used to monitor the selective and reversible binding of pH sensitive, macrocyclic lanthanide complexes,[LnL1], to the serum protein α1-AGP, whose concentration can vary significantly in response to inflam…
View article: Novel Antibacterial Coating on Orthopedic Wires To Eliminate Pin Tract Infections
Novel Antibacterial Coating on Orthopedic Wires To Eliminate Pin Tract Infections Open
Novel approaches to the prevention of microbial infections after the insertion of orthopedic external fixators are in great demand because of the extremely high incidence rates of such infections, which can reach up to 100% with longer imp…
View article: Responsive, Water‐Soluble Europium(III) Luminescent Probes
Responsive, Water‐Soluble Europium(III) Luminescent Probes Open
The design principles, mechanism of action and performance of europium(III) complexes that serve as strongly emissive and responsive molecular probes in water are critically discussed. Examples of systems designed to assess pH, selected me…
View article: CCDC 1561807: Experimental Crystal Structure Determination
CCDC 1561807: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1561809: Experimental Crystal Structure Determination
CCDC 1561809: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1561808: Experimental Crystal Structure Determination
CCDC 1561808: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Selectively switching on europium emission in drug site one of human serum albumin
Selectively switching on europium emission in drug site one of human serum albumin Open
A luminescent europium probe has been discovered that binds selectively to drug-site I in human serum albumin, signalled by a ‘switching on’ of europium emission, and accompanied by strong induced circularly polarised luminescence.
View article: Electromagnetic susceptibility anisotropy and its importance for paramagnetic NMR and optical spectroscopy in lanthanide coordination chemistry
Electromagnetic susceptibility anisotropy and its importance for paramagnetic NMR and optical spectroscopy in lanthanide coordination chemistry Open
Electromagnetic susceptibility anisotropy can explain the spectroscopy and magnetism of lanthanide containing systems, but current theories have limitations.