Sergey V. Brodsky
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View article: Platelet Dysfunction in Chronic Kidney Disease Arises from Bone Marrow Remodeling and Megakaryocyte Reprogramming
Platelet Dysfunction in Chronic Kidney Disease Arises from Bone Marrow Remodeling and Megakaryocyte Reprogramming Open
Chronic kidney disease (CKD) is associated with an increased risk of thrombotic events, yet the underlying mechanisms driving platelet dysfunction remain incompletely understood. Historically, platelet abnormalities in CKD have been attrib…
View article: Genomewide Screen Identifies Peroxisomal Role in APOL1 Podocytopathy
Genomewide Screen Identifies Peroxisomal Role in APOL1 Podocytopathy Open
The G1 and G2 variants of the APOL1 gene increase the risk of chronic kidney disease (CKD) in individuals of African descent. In the presence of secondary stressors such as inflammation and hypoxia, these gain-of-function variants can indu…
View article: Proteinuria and proximal tubular epithelial cells: correlation between immunofluorescence, histology, and degree of proteinuria
Proteinuria and proximal tubular epithelial cells: correlation between immunofluorescence, histology, and degree of proteinuria Open
Proteins are filtered from the blood through the glomerular filtration barrier. Filtered proteins are reabsorbed by proximal tubular epithelial cells (PTECs), which have been shown to possess the ability to regulate protein reabsorption. H…
View article: Role of plasminogen activated inhibitor-1 in the pathogenesis of anticoagulant related nephropathy
Role of plasminogen activated inhibitor-1 in the pathogenesis of anticoagulant related nephropathy Open
Anticoagulant related nephropathy (ARN) is the result of glomerular hemorrhage in patients on systemic anticoagulation therapy or underlying coagulopathy. Red blood cells (RBC) that passed through the glomerular filtration barrier form RBC…
View article: WCN24-1960 Membranous glomerulonephritis with unusual C3 deposits: case series report
WCN24-1960 Membranous glomerulonephritis with unusual C3 deposits: case series report Open
Introduction: Methods: Results: We present an unusual cases of MN that showed some features of primary MN, but also features resembling C3 glomerulonephritis. None of the patients had underlying autoimmune disease, monoclonal gammopathy or…
View article: Kidney Biopsy Corner: Amyloidosis
Kidney Biopsy Corner: Amyloidosis Open
Amyloidosis is an infiltrative disease caused by misfolded proteins depositing in tissues. Amyloid infiltrates the kidney in several patterns. There are, as currently described by the International Society of Amyloidosis, 14 types of amylo…
View article: Correlation of Red Blood Cell Casts With Renal Dysfunction in Patients With Infection-Related Glomerulonephritis
Correlation of Red Blood Cell Casts With Renal Dysfunction in Patients With Infection-Related Glomerulonephritis Open
Context Infection-related glomerulonephritis (IRGN) usually manifests as a proliferative immune-complex glomerulonephritis. The degree of renal dysfunction at presentation can vary. Association with histologic features on kidney biopsy rem…
View article: Clinical Evaluation and Management of Thrombotic Microangiopathy
Clinical Evaluation and Management of Thrombotic Microangiopathy Open
Thrombotic microangiopathy (TMA) refers to a diverse group of diseases that share clinical and histopathologic features. TMA is clinically characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and organ injury t…
View article: N‐acetylcysteine ameliorates hematuria‐associated tubulointerstitial injury in 5/6 nephrectomy mice
N‐acetylcysteine ameliorates hematuria‐associated tubulointerstitial injury in 5/6 nephrectomy mice Open
Chronic kidney disease (CKD) is characterized by increased interstitial fibrosis and tubular atrophy (IFTA) in the kidney. Chronic hematuria is a hallmark of several human kidney diseases and often is seen in patients on anticoagulation th…
View article: Prothrombin Knockdown Protects Podocytes and Reduces Proteinuria in Glomerular Disease
Prothrombin Knockdown Protects Podocytes and Reduces Proteinuria in Glomerular Disease Open
Chronic kidney disease (CKD) is a leading cause of death, and its progression is driven by glomerular podocyte injury and loss, manifesting as proteinuria. Proteinuria includes urinary loss of coagulation zymogens, cofactors, and inhibitor…
View article: Isolated arterial mucoid intimal thickening lesion in early post‐transplant kidney allograft biopsies
Isolated arterial mucoid intimal thickening lesion in early post‐transplant kidney allograft biopsies Open
Isolated arterial mucoid intimal thickening in early post-transplant biopsies may be an early/mild form of TMA, probably requiring adjustment in immunosuppressive regimen. Careful exclusion of known causes of TMA, and donor-derived arteria…
View article: Clinical Outcomes in Patients With Biopsy Proven Anticoagulant-Related Nephropathy
Clinical Outcomes in Patients With Biopsy Proven Anticoagulant-Related Nephropathy Open
Anticoagulant-related nephropathy (ARN) was first described over 13 years ago as warfarin-related nephropathy (WRN). A cohort of patients on warfarin therapy with increased international normalized ratio developed acute kidney injury.1 Kid…
View article: Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab
Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab Open
An 81-year-old woman was referred to nephrology for a follow-up on progressive chronic kidney disease. She has a past medical history of hypertension, T2DM, breast cancer, and secondary hyperparathyroidism related to renal disease. A renal…
View article: A Rare Case of Recurrent Immunotactoid Glomerulonephritis
A Rare Case of Recurrent Immunotactoid Glomerulonephritis Open
Immunotactoid glomerulopathy is an uncommon cause of glomerular disease that results from deposits derived from immunoglobulins. This rare disease can occur in native kidneys and in transplant patients. They are present only in 0.5% to 1.4…
View article: Research Letter: Is the 129S1/SvImJ Mouse Strain More Suitable to Study Anticoagulant-Related Nephropathy Than the C57BL/6 Strain?
Research Letter: Is the 129S1/SvImJ Mouse Strain More Suitable to Study Anticoagulant-Related Nephropathy Than the C57BL/6 Strain? Open
Background: We have previously demonstrated that excessive anticoagulation with warfarin or dabigatran may result in acute kidney injury with red blood cell (RBC) tubular casts in some patients with chronic kidney disease, and this conditi…
View article: Glomerular crescents, IgA-deposits, ANCA, infection – unravelling the diagnostic conundrum
Glomerular crescents, IgA-deposits, ANCA, infection – unravelling the diagnostic conundrum Open
Introduction Glomerulonephritis (GN) with crescents and IgA deposits on kidney biopsy poses a frequent diagnostic and therapeutic dilemma because of multiple possibilities. Methods Native kidney biopsies showing IgA deposition and crescent…
View article: Triple hit to the kidney-dual pathological crescentic glomerulonephritis and diffuse proliferative immune complex-mediated glomerulonephritis: A case report
Triple hit to the kidney-dual pathological crescentic glomerulonephritis and diffuse proliferative immune complex-mediated glomerulonephritis: A case report Open
Our case emphasizes the importance of a renal biopsy in anti-GBM disease, even in the presence of positive serum anti-GBM antibodies, to identify other potential causes of rapidly progressive glomerulonephritis. The challenge in treating s…
View article: Subclass Changes in Fibrillary Glomerulonephritis
Subclass Changes in Fibrillary Glomerulonephritis Open
Fibrillary glomerulonephritis (FGN) is a rare glomerular disease diagnosed by renal biopsy and characterized by nonperiodic fibrillar deposits of immunoglobulins in the glomeruli with a mean diameter of 20 nm. Although rarely monotypic, on…
View article: Genomic Study on Blood Culture Isolates From Patients With Staphylococcus Infection-associated Glomerulonephritis
Genomic Study on Blood Culture Isolates From Patients With Staphylococcus Infection-associated Glomerulonephritis Open
INTRODUCTION: Staphylococcus infection-associated glomerulonephritis (SAGN), is an autoimmune sequela of infection affecting a subset of infected patients without specific predictive factors, frequently presenting with acute nephritic synd…
View article: Role of protease‐activated receptor‐1 (PAR‐1) in the glomerular filtration barrier integrity
Role of protease‐activated receptor‐1 (PAR‐1) in the glomerular filtration barrier integrity Open
Protease‐activated receptors (PAR) play an important role in the regulation of cellular function by the coagulation system, and they are activated by thrombin. PAR‐1 is expressed in both endothelial cells and podocytes in the kidney. The r…
View article: Kidney Biopsy Techniques to Differentiate Calcium Oxalate and Dihydroxyadenine Tubular Crystals
Kidney Biopsy Techniques to Differentiate Calcium Oxalate and Dihydroxyadenine Tubular Crystals Open
One of the most challenging aspects of kidney pathology is the differential diagnosis of crystal deposition. Some crystals (calcium oxalate [CaOx] crystals and 2,8-dihydroxyadenine [DHA] crystals) show bright birefringence under polarized …
View article: Acute Interstitial Nephritis Triggered by a Novel Anti-CD25 Antibody-Drug Conjugate, Camidanlumab Tesirine
Acute Interstitial Nephritis Triggered by a Novel Anti-CD25 Antibody-Drug Conjugate, Camidanlumab Tesirine Open
Interleukin-2 (IL-2) is an essential cytokine in cellular immunity responsible for stimulating T cell proliferation and the development of effector and memory T lymphocyte responses. IL-2 exerts its functional effects by interaction with t…
View article: Chronic Hematuria Increases Chronic Kidney Injury and Epithelial–Mesenchymal Transition in 5/6 Nephrectomy Rats
Chronic Hematuria Increases Chronic Kidney Injury and Epithelial–Mesenchymal Transition in 5/6 Nephrectomy Rats Open
Chronic kidney disease (CKD) is a common outcome of many kidney diseases. Interstitial fibrosis and tubular atrophy (IFTA) is a histologic hallmark of CKD. Hematuria is a common symptom in many human kidney diseases. Free hemoglobin may af…
View article: Autopsy Techniques in Patients With History of Radiofrequency Ablation for Atrial Fibrillation
Autopsy Techniques in Patients With History of Radiofrequency Ablation for Atrial Fibrillation Open
Context.— Esophageal fistula formation is one of the most feared complications of radiofrequency catheter ablation. This procedure and its many variations, such as the “maze,” are becoming the mainstream treatment for atrial fibrillation o…
View article: Can Antinuclear Antibodies (ANA) be Monoclonal?
Can Antinuclear Antibodies (ANA) be Monoclonal? Open
Background. Nuclear staining by immunofluorescence in a kidney biopsy is often seen in patients with positive antinuclear antibodies (ANA) in the serum. These ANA are usually polyclonal, but herein we report 9 cases with an unusual finding…
View article: Hypertension and the Kidney: Reduced Kidney Mass Is Bad for Both Normotensive and Hypertensive Rats
Hypertension and the Kidney: Reduced Kidney Mass Is Bad for Both Normotensive and Hypertensive Rats Open
BACKGROUND Hypertension is a leading cause of chronic kidney disease worldwide. Early studies demonstrated the short-term effects of hypertension on kidney function and morphology in ablative nephropathy. The aim of this study was to inves…