Sergey V. Plotnikov
YOU?
Author Swipe
View article: A tale of two distinct actin networks underlies the entire life cycle of focal adhesion
A tale of two distinct actin networks underlies the entire life cycle of focal adhesion Open
Cell assembles focal adhesion (FA) to transmit the stress fiber (SF)-based actomyosin contraction onto the extracellular matrix (ECM) for mesenchymal migration, essential for many physiological processes ( e.g. , development and wound heal…
View article: Methacrylated epigallocatechin gallate functionalized dental adhesives: Antiproteolytic activity and dentin bonding studies
Methacrylated epigallocatechin gallate functionalized dental adhesives: Antiproteolytic activity and dentin bonding studies Open
EGCG-methacrylate monomers effectively protected collagen from degradation. When incorporated into adhesive systems, EGCG-methacrylates reduced gelatinolytic activity within the hybrid layer, and did not affect immediate and long-term bond…
View article: A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration Open
SUMMARY Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin-based lamellipodia protrusions, powered by actin polymerizati…
View article: Cultured primary turtle hepatocytes: a cellular model for the study of temperature and anoxia
Cultured primary turtle hepatocytes: a cellular model for the study of temperature and anoxia Open
We have optimized a methodology for two-dimensional (2-D) culturing of primary western painted turtle hepatocytes and used this model to study the effects of cyanide and temperature on structural rearrangement, and the effect of cyanide on…
View article: Membrane ruffling is a mechanosensor of extracellular fluid viscosity
Membrane ruffling is a mechanosensor of extracellular fluid viscosity Open
View article: Mechanosensitive Regulation of Fibrosis
Mechanosensitive Regulation of Fibrosis Open
Cells in the human body experience and integrate a wide variety of environmental cues. A growing interest in tissue mechanics in the past four decades has shown that the mechanical properties of tissue drive key biological processes and fa…
View article: Force-Dependent Activation of Actin Elongation Factor mDia1 Protects the Cytoskeleton from Mechanical Damage and Facilitates Stress Fiber Repair
Force-Dependent Activation of Actin Elongation Factor mDia1 Protects the Cytoskeleton from Mechanical Damage and Facilitates Stress Fiber Repair Open
View article: Publisher Correction: A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions
Publisher Correction: A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions Open
View article: A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions
A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions Open
The interrelationship between microtubules and the actin cytoskeleton in mechanoregulation of integrin-mediated adhesions is poorly understood. Here, we show that the effects of microtubules on two major types of cell-matrix adhesion, foca…
A Noisy Analog-to-Digital Converter Connects Cytosolic Calcium Bursts to Transcription Factor Nuclear Localization Pulses in Yeast Open
View article: Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease
Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease Open
G protein-coupled receptors (GPCRs) are crucial sensors of extracellular signals in eukaryotes, and direct measurement of GPCR-mediated signaling is useful for high-throughput mutational studies. However, this is particularly difficult for…
View article: Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo
Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo Open
View article: An analog to digital converter creates nuclear localization pulses in yeast calcium signaling
An analog to digital converter creates nuclear localization pulses in yeast calcium signaling Open
Several examples of transcription factors that show stochastic, unsynchronized pulses of nuclear localization have been described. Here we show that under constant calcium stress, nuclear localization pulses of the transcription factor Crz…
View article: Two Distinct Actin Networks Mediate Traction Oscillations to Confer Focal Adhesion Mechanosensing
Two Distinct Actin Networks Mediate Traction Oscillations to Confer Focal Adhesion Mechanosensing Open
View article: Bridging the gap
Bridging the gap Open
A new study reveals that a protein called talin forms a vital link between microtubules and focal adhesions at the surface of cells.
View article: A lateral signalling pathway coordinates shape volatility during cell migration
A lateral signalling pathway coordinates shape volatility during cell migration Open
View article: RETRACTED: Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly
RETRACTED: Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly Open
Actin filaments and integrin-based focal adhesions (FAs) form integrated systems that mediate dynamic cell interactions with their environment or other cells during migration, the immune response, and tissue morphogenesis. How adhesion-ass…
View article: Two Distinct Actin Networks Mediate Traction Oscillations to Confer Mechanosensitivity of Focal Adhesions
Two Distinct Actin Networks Mediate Traction Oscillations to Confer Mechanosensitivity of Focal Adhesions Open