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View article: Efficient stem cell-derived mouse embryo models for environmental studies
Efficient stem cell-derived mouse embryo models for environmental studies Open
Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield incomplete structures that fail to cavitat…
View article: The first two blastomeres contribute unequally to the human embryo
The first two blastomeres contribute unequally to the human embryo Open
Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in the body can be traced to the 2-cell stage embryo. However, whether and how such clonal asymmetries arise in the embryo is unclear. Here, we perform…
View article: Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division
Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division Open
The Wnt-pathway is part of a signalling network that regulates many aspects of cell biology. Recently, we discovered crosstalk between AMPA/Kainate-type ionotropic glutamate receptors (iGluRs) and the Wnt-pathway during the initial Wnt3a-i…
View article: Pluripotency state regulates cytoneme selectivity and self-organization of embryonic stem cells
Pluripotency state regulates cytoneme selectivity and self-organization of embryonic stem cells Open
To coordinate cell fate with changes in spatial organization, stem cells (SCs) require specific and adaptable systems of signal exchange and cell-to-cell communication. Pluripotent embryonic stem cells (ESCs) use cytonemes to pair with tro…
View article: Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair
Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair Open
The maintenance of human skeletal stem cells (hSSCs) and their progeny in bone defects is a major challenge. Here, we report on a transplantable bandage containing a three-dimensional Wnt-induced osteogenic tissue model (WIOTM). This banda…
View article: Wnt- and Glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division
Wnt- and Glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division Open
The Wnt-pathway is part of a signalling network that regulates many aspects of cell biology. Recently we discovered crosstalk between AMPA/Kainate-type ionotropic glutamate receptors (iGluRs) and the Wnt-pathway during the initial Wnt3a-in…
View article: Specialized cytonemes induce self-organization of stem cells
Specialized cytonemes induce self-organization of stem cells Open
Significance Many questions about how stem cells communicate with neighboring cells and self-organize to initiate tissue formation remain unanswered. We uncovered mechanisms employed by embryonic stem cells (ESCs) and trophoblast stem cell…