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View article: A Mutation in the RNA-Binding Protein Cth2 Limits the Adaptation of a Subset of Wild <i>Saccharomyces cerevisiae</i> Yeast Strains to Iron Deficiency
A Mutation in the RNA-Binding Protein Cth2 Limits the Adaptation of a Subset of Wild <i>Saccharomyces cerevisiae</i> Yeast Strains to Iron Deficiency Open
Iron is an essential micronutrient for eukaryotic organisms. In response to iron deficiency, the yeast Saccharomyces cerevisiae optimizes iron utilization by downregulating nonessential iron-dependent processes, such as mitochondria…
View article: A pilot study evaluating the 3D morphology of melanocytic lesions with LC-OCT and correlating findings to histopathology and RCM
A pilot study evaluating the 3D morphology of melanocytic lesions with LC-OCT and correlating findings to histopathology and RCM Open
View article: Desmoplastic Melanoma: Clinical Features, Prognostic Implications, and Survival Analysis from a 24-Year Cohort Study
Desmoplastic Melanoma: Clinical Features, Prognostic Implications, and Survival Analysis from a 24-Year Cohort Study Open
View article: [Translated article] Multicenter Analysis of the Surgical Management and Adjuvant Therapy of Patients With Melanoma and a Positive Sentinel Lymph Node Biopsy
[Translated article] Multicenter Analysis of the Surgical Management and Adjuvant Therapy of Patients With Melanoma and a Positive Sentinel Lymph Node Biopsy Open
While the frequency of CLND in patients with melanoma and positive SLNB has decreased, the indication for systemic adjuvant therapy in these patients has increased. However, CLND is still indicated in patients with high-risk characteristic…
View article: The role of the Arabidopsis tandem zinc-finger C3H15 protein in metal homeostasis
The role of the Arabidopsis tandem zinc-finger C3H15 protein in metal homeostasis Open
View article: Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation
Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation Open
Iron serves as a cofactor for enzymes involved in several steps of protein translation, but the control of translation during iron limitation is not understood at the molecular level. Here, we report a genome-wide analysis of protein trans…
View article: Regulation of translation in response to iron deficiency in human cells
Regulation of translation in response to iron deficiency in human cells Open
Protein synthesis is a highly energy-consuming process that is downregulated in response to many environmental stresses or adverse conditions. Studies in the yeast Saccharomyces cerevisiae have shown that bulk translation is inhibited duri…
View article: Analysis of risk factors in melanoma survivors for the development of non-melanoma skin cancer
Analysis of risk factors in melanoma survivors for the development of non-melanoma skin cancer Open
View article: Iron drives anabolic metabolism through active histone demethylation and mTORC1
Iron drives anabolic metabolism through active histone demethylation and mTORC1 Open
View article: The yeast mRNA-binding protein Cth2 post-transcriptionally modulates ergosterol biosynthesis in response to iron deficiency
The yeast mRNA-binding protein Cth2 post-transcriptionally modulates ergosterol biosynthesis in response to iron deficiency Open
View article: Adaptation of Saccharomyces Species to High-Iron Conditions
Adaptation of Saccharomyces Species to High-Iron Conditions Open
Iron is an indispensable element that participates as an essential cofactor in multiple biological processes. However, when present in excess, iron can engage in redox reactions that generate reactive oxygen species that damage cells at mu…
View article: Genome-wide ribosome profiling uncovers the role of iron in the control of protein translation
Genome-wide ribosome profiling uncovers the role of iron in the control of protein translation Open
Iron is an essential trace element that serves as a cofactor for enzymes involved in multiple metabolic pathways, including ribosome biogenesis, protein translation, DNA synthesis and repair, lipid metabolism, and mitochondrial oxidative p…
View article: Iron Drives Anabolic Metabolism Through Active Histone Demethylation and mTORC1
Iron Drives Anabolic Metabolism Through Active Histone Demethylation and mTORC1 Open
All living cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate anabolic processes are unclear. Here, we report a universal eukaryotic pathway for iron sensing…
View article: Transcriptional regulation of ergosterol biosynthesis genes in response to iron deficiency
Transcriptional regulation of ergosterol biosynthesis genes in response to iron deficiency Open
Iron participates as an essential cofactor in the biosynthesis of critical cellular components, including DNA, proteins and lipids. The ergosterol biosynthetic pathway, which is an important target of antifungal treatments, depends on iron…
View article: Modulation of yeast Erg1 expression and terbinafine susceptibility by iron bioavailability
Modulation of yeast Erg1 expression and terbinafine susceptibility by iron bioavailability Open
Ergosterol is a specific sterol component of yeast and fungal membranes. Its biosynthesis is one of the most effective targets for antifungal treatments. However, the emergent resistance to multiple sterol‐based antifungal drugs emphasizes…
View article: Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function
Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function Open
View article: Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function
Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function Open
Iron dyshomeostasis contributes to aging, but little information is available about the molecular mechanisms. Here, we provide evidence that, in Saccharomyces cerevisiae , aging is associated with altered expression of genes involved in ir…
View article: Changes in mRNA stability play an important role in the adaptation of yeast cells to iron deprivation
Changes in mRNA stability play an important role in the adaptation of yeast cells to iron deprivation Open
View article: The role of post-transcriptional modulators of metalloproteins in response to metal deficiencies
The role of post-transcriptional modulators of metalloproteins in response to metal deficiencies Open
Copper and iron proteins have a wide range of functions in living organisms. Metal assembly into metalloproteins is a complex process, where mismetalation is detrimental and energy consuming to cells. Under metal deficiency, metal distribu…
View article: Sterol Composition Modulates the Response of Saccharomyces cerevisiae to Iron Deficiency
Sterol Composition Modulates the Response of Saccharomyces cerevisiae to Iron Deficiency Open
Iron is a vital micronutrient that functions as an essential cofactor in multiple biological processes, including oxygen transport, cellular respiration, and metabolic pathways, such as sterol biosynthesis. However, its low bioavailability…
View article: Identification and molecular characterization of the high-affinity copper transporters family in Solanum lycopersicum
Identification and molecular characterization of the high-affinity copper transporters family in Solanum lycopersicum Open
Copper (Cu) plays a key role as cofactor in the plant proteins participating in essential cellular processes, such as electron transport and free radical scavenging. Despite high-affinity Cu transporters (COPTs) being key participants in C…
View article: Both human and soya bean ferritins highly improve the accumulation of bioavailable iron and contribute to extend the chronological life in budding yeast
Both human and soya bean ferritins highly improve the accumulation of bioavailable iron and contribute to extend the chronological life in budding yeast Open
Summary Ferritin proteins have an enormous capacity to store iron in cells. In search for the best conditions to accumulate and store bioavailable iron, we made use of a double mutant null for the monothiol glutaredoxins GRX3 and GRX4 . Th…
View article: Data supporting the results published in the paper entitled "Sterol composition modulates the response of Saccharomyces cerevisiae to iron deficiency"
Data supporting the results published in the paper entitled "Sterol composition modulates the response of Saccharomyces cerevisiae to iron deficiency" Open
The dataset is made available under the Open Database License. Any rights in individual contents of the database are licensed under the Database Contents License. Please, read the full ODbL 1.0 license text for the exact terms that apply. …
View article: Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron
Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron Open
Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox cofactor in multiple metabolic processes. Iron bioavailability is highly restricted due to the low solubility of its oxidized form, frequent…
View article: Iron in Translation: From the Beginning to the End
Iron in Translation: From the Beginning to the End Open
Iron is an essential element for all eukaryotes, since it acts as a cofactor for many enzymes involved in basic cellular functions, including translation. While the mammalian iron-regulatory protein/iron-responsive element (IRP/IRE) system…
View article: Data supporting the results published in the paper entitled Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron
Data supporting the results published in the paper entitled Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron Open
The dataset is made available under the Open Database License. Any rights in individual contents of the database are licensed under the Database Contents License. Please, read the full ODbL 1.0 license text for the exact terms that apply. …
View article: The Jumonji-C Histone Lysine Demethylase KDM3B Senses Cellular Iron to Regulate Anabolism Through mTORC1
The Jumonji-C Histone Lysine Demethylase KDM3B Senses Cellular Iron to Regulate Anabolism Through mTORC1 Open
View article: Iron Regulatory Mechanisms in Saccharomyces cerevisiae
Iron Regulatory Mechanisms in Saccharomyces cerevisiae Open
Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox cofactor in many cellular processes. However, excess iron can damage cells since it promotes the generation of reactive oxygen species. The …
View article: Deregulated High Affinity Copper Transport Alters Iron Homeostasis in Arabidopsis
Deregulated High Affinity Copper Transport Alters Iron Homeostasis in Arabidopsis Open
The present work describes the effects on iron homeostasis when copper transport was deregulated in Arabidopsis thaliana by overexpressing high affinity copper transporters COPT1 and COPT3 (COPTOE ). A genome-wide …
View article: Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae Open
Ergosterol is an essential component of fungal cell membranes that determines the fluidity, permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a complex and highly energy-consuming pathway that involves t…