Sergio B. Socías
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View article: DDOX expands the repertoire of tetracyclines for Parkinson’s disease by preventing the cellular uptake and intracellular impact of α-synuclein preformed fibrils
DDOX expands the repertoire of tetracyclines for Parkinson’s disease by preventing the cellular uptake and intracellular impact of α-synuclein preformed fibrils Open
View article: Magnetic Amyloid-Based Biocatalyst for the Hydrolysis of Urea
Magnetic Amyloid-Based Biocatalyst for the Hydrolysis of Urea Open
View article: Humoral immunoresponse elicited against an adenoviral-based SARS-CoV-2 coronavirus vaccine in elderly patients
Humoral immunoresponse elicited against an adenoviral-based SARS-CoV-2 coronavirus vaccine in elderly patients Open
The early sequencing of the SARS-CoV-2 viral genome allowed for a speedy development of effective vaccines against the virus. Nevertheless, age-related immunosenescence, the inability to mount strong immune responses, still represents a ma…
View article: Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound
Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound Open
The antibiotic tetracycline demeclocycline (DMC) was recently reported to rescue α-synuclein (α-Syn) fibril-induced pathology. However, the antimicrobial activity of DMC precludes its potential use in long-term neuroprotective treatments. …
View article: Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound
Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound Open
The antibiotic tetracycline demeclocycline (DMC) was recently reported to rescue α-synuclein (α-Syn) fibril-induced pathology. However, the antimicrobial activity of DMC precludes its po-tential use in long-term neuroprotective…
View article: Long-term analysis of antibodies elicited by SPUTNIK V: A prospective cohort study in Tucumán, Argentina
Long-term analysis of antibodies elicited by SPUTNIK V: A prospective cohort study in Tucumán, Argentina Open
View article: Elevated Humoral Immune Response to SARS-CoV-2 at High Altitudes Revealed by an Anti-RBD “In-House” ELISA
Elevated Humoral Immune Response to SARS-CoV-2 at High Altitudes Revealed by an Anti-RBD “In-House” ELISA Open
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a global pandemic with dramatic health and socioeconomic consequences. The Coronavirus Disease 2019 (COVID-19) challenges health systems to quickly respond by deve…
View article: Past SARS-CoV-2 infection elicits a strong immune response after a single vaccine dose
Past SARS-CoV-2 infection elicits a strong immune response after a single vaccine dose Open
We hypothesized that in individuals with previous SARS-CoV-2 infection, the first vaccine dose would work as a booster, eliciting a faster and more intense immune response. We herein describe antibody responses to the first and second dose…
View article: Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity
Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity Open
Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecul…
View article: Long-Term Analysis of Antibodies Elicited by Sputnik V in Tucuman, Argentina
Long-Term Analysis of Antibodies Elicited by Sputnik V in Tucuman, Argentina Open
View article: Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity
Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity Open
Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecul…
View article: CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects
CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects Open
View article: Tetracycline repurposing in neurodegeneration: focus on Parkinson’s disease
Tetracycline repurposing in neurodegeneration: focus on Parkinson’s disease Open
View article: Lessons learned from protein aggregation: toward technological and biomedical applications
Lessons learned from protein aggregation: toward technological and biomedical applications Open
View article: Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species
Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species Open
View article: A simplified approach for efficient isolation of functional microglial cells: Application for modeling neuroinflammatory responses <i>in vitro</i>
A simplified approach for efficient isolation of functional microglial cells: Application for modeling neuroinflammatory responses <i>in vitro</i> Open
Purified microglial cells in culture are frequently used to model brain inflammatory responses but obtaining large yields of these cells on a routine basis can be quite challenging. Here, we demonstrate that it is possible to achieve high‐…
View article: Novel tactics for neuroprotection in Parkinson's disease: Role of antibiotics, polyphenols and neuropeptides
Novel tactics for neuroprotection in Parkinson's disease: Role of antibiotics, polyphenols and neuropeptides Open