Sergio Bagnato
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View article: Assessing the Accuracy of ChatGPT in Answering Questions About Prolonged Disorders of Consciousness
Assessing the Accuracy of ChatGPT in Answering Questions About Prolonged Disorders of Consciousness Open
Objectives: Prolonged disorders of consciousness (DoC) present complex diagnostic and therapeutic challenges. This study aimed to evaluate the accuracy of two ChatGPT models (ChatGPT 4o and ChatGPT o1) in answering questions about prolonge…
View article: Pancreatic Volume in Thalassemia: Determinants and Association with Alterations of Glucose Metabolism
Pancreatic Volume in Thalassemia: Determinants and Association with Alterations of Glucose Metabolism Open
Objectives: This study aimed to compare the pancreatic volume between beta-thalassemia major (β-TM) and beta-thalassemia intermedia (β-TI) patients and between thalassemia patients and healthy subjects and to determine the predictors of pa…
View article: Prism adaptation combined with serious games for improving visual-constructive abilities in stroke patients: randomized clinical trial
Prism adaptation combined with serious games for improving visual-constructive abilities in stroke patients: randomized clinical trial Open
Introduction Visuomotor adaptation to a displacement of the visual field induced by prismatic lenses can help rehabilitate cognitive deficits when combined with digital cognitive training. The aim of this study was to evaluate the effectiv…
View article: Magnetic Resonance Evaluation of Tissue Iron Deposition and Cardiac Function in Adult Regularly Transfused Thalassemia Intermedia Compared with Thalassemia Major Patients
Magnetic Resonance Evaluation of Tissue Iron Deposition and Cardiac Function in Adult Regularly Transfused Thalassemia Intermedia Compared with Thalassemia Major Patients Open
Objectives: This multicenter, retrospective, population-based, matched-cohort study compared clinical characteristics and magnetic resonance imaging (MRI) findings, including hepatic, pancreatic, and cardiac iron levels and cardiac functio…
View article: Oxidative Stress and Antioxidant Status in Adult Patients with Transfusion-Dependent Thalassemia: Correlation with Demographic, Laboratory, and Clinical Biomarkers
Oxidative Stress and Antioxidant Status in Adult Patients with Transfusion-Dependent Thalassemia: Correlation with Demographic, Laboratory, and Clinical Biomarkers Open
Iron overload in beta transfusion-dependent thalassemia (β-TDT) may provoke oxidative stress and reduction of the antioxidant defenses, with serious consequences for the disease course and complications. The present study evaluated the oxi…
View article: Low Vitamin D Levels Are Associated with Increased Cardiac Iron Uptake in Beta-Thalassemia Major
Low Vitamin D Levels Are Associated with Increased Cardiac Iron Uptake in Beta-Thalassemia Major Open
We evaluated the association of vitamin D and parathormone (PTH) levels with cardiac iron and function in beta-thalassemia major (β-TM) patients. Two-hundred and seventy-eight TM patients (39.04 ± 8.58 years, 56.8% females) underwent magne…
View article: Free Thyroxine (fT4) as a Potential Biomarker of Neurological and Functional Outcome in Acquired Brain Injury: A Prospective Multicenter Cohort Study
Free Thyroxine (fT4) as a Potential Biomarker of Neurological and Functional Outcome in Acquired Brain Injury: A Prospective Multicenter Cohort Study Open
The potential involvement of thyroid hormones (THs) in the neurological and functional recovery of patients with brain damage has been hypothesized. We aimed at investigating the role of THs and their variations during the rehabilitation p…
View article: Investigating microRNAs as biomarkers in disorders of consciousness: a longitudinal multicenter study
Investigating microRNAs as biomarkers in disorders of consciousness: a longitudinal multicenter study Open
MicroRNAs (miRNAs) are involved in gene regulation and may affect secondary brain injury and recovery in patients with disorders of consciousness (DoC). This study investigated the role of five miRNAs (150-5p, 132-3p, 23b-3p, 451a, and 16-…
View article: Phenotypic Clustering of Beta-Thalassemia Intermedia Patients Using Cardiovascular Magnetic Resonance
Phenotypic Clustering of Beta-Thalassemia Intermedia Patients Using Cardiovascular Magnetic Resonance Open
We employed an unsupervised clustering method that integrated demographic, clinical, and cardiac magnetic resonance (CMR) data to identify distinct phenogroups (PGs) of patients with beta-thalassemia intermedia (β-TI). We considered 138 β-…
View article: Progress and Challenges in Understanding Disorders of Consciousness following Acute Brain Injury
Progress and Challenges in Understanding Disorders of Consciousness following Acute Brain Injury Open
IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science. With a long tradition and wide readersh…
View article: Cerebrospinal Fluid and Blood Biomarkers in Patients with Post-Traumatic Disorders of Consciousness: A Scoping Review
Cerebrospinal Fluid and Blood Biomarkers in Patients with Post-Traumatic Disorders of Consciousness: A Scoping Review Open
(1) Background: Cerebrospinal fluid (CSF) and blood biomarkers are emerging tools used to obtain information on secondary brain damage and to improve diagnostic and prognostic accuracy for patients with prolonged post-traumatic disorders o…
View article: Predicting Long-Term Recovery of Consciousness in Prolonged Disorders of Consciousness Based on Coma Recovery Scale-Revised Subscores: Validation of a Machine Learning-Based Prognostic Index
Predicting Long-Term Recovery of Consciousness in Prolonged Disorders of Consciousness Based on Coma Recovery Scale-Revised Subscores: Validation of a Machine Learning-Based Prognostic Index Open
Prognosis of prolonged Disorders of Consciousness (pDoC) is influenced by patients’ clinical diagnosis and Coma Recovery Scale-Revised (CRS-R) total score. We compared the prognostic accuracy of a novel Consciousness Domain Index (CDI) wit…
View article: Impact of seizures and their prophylaxis with antiepileptic drugs on rehabilitation course of patients with traumatic or hemorrhagic brain injury
Impact of seizures and their prophylaxis with antiepileptic drugs on rehabilitation course of patients with traumatic or hemorrhagic brain injury Open
Objective To determine whether, in patients undergoing rehabilitation after traumatic or hemorrhagic brain injury, seizures and the use of antiepileptic drugs (AEDs) negatively impact on functional outcome, and, in turn, whether prophylact…
View article: Thyrotropic Axis and Disorders of Consciousness in Acquired Brain Injury: A Potential Intriguing Association?
Thyrotropic Axis and Disorders of Consciousness in Acquired Brain Injury: A Potential Intriguing Association? Open
Purpose A potential involvement of thyrotropic axis in influencing the state of consciousness could be hypothesized. We aimed at investigating thyroid function tests as predictors of disorders of consciousness (DoC) and relating recovery i…
View article: Biomarkers of Brain Injury: A Window on Mechanisms of Injury and Recovery in the Brain
Biomarkers of Brain Injury: A Window on Mechanisms of Injury and Recovery in the Brain Open
The decision-making process regarding management after severe acute brain injury is based on clinical evaluation and depends on the injury etiology as well as radiological and neurophysiological data [...]
View article: COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation
COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation Open
Background: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who unde…
View article: Risk factors for 2‐year mortality in patients with prolonged disorders of consciousness: An international multicentre study
Risk factors for 2‐year mortality in patients with prolonged disorders of consciousness: An international multicentre study Open
Background and purpose Patients with prolonged disorders of consciousness (pDoC) have a high mortality rate due to medical complications. Because an accurate prognosis is essential for decision‐making on patients' management, we analysed d…
View article: Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
Sustained Axonal Degeneration in Prolonged Disorders of Consciousness Open
(1) Background: Sustained axonal degeneration may play a critical role in prolonged disorder of consciousness (DOCs) pathophysiology. We evaluated levels of neurofilament light chain (NFL), an axonal injury marker, in patients with unrespo…
View article: Multicenter prospective study on predictors of short-term outcome in disorders of consciousness
Multicenter prospective study on predictors of short-term outcome in disorders of consciousness Open
Objective: This international multicenter, prospective, observational study aimed at identifying predictors of short-term clinical outcome in patients with prolonged disorders of consciousness (DoC) due to acquired severe brain injury. Met…
View article: Multicenter prospective study on predictors of short-term outcome in disorders of consciousness
Multicenter prospective study on predictors of short-term outcome in disorders of consciousness Open
Multimodal assessment could identify patients with higher likelihood of clinical improvement in order to help clinicians, families, and funding sources with various aspects of decision-making. This multicenter, international study aims to …
View article: Neurologic Deterioration in Sinking Skin Flap Syndrome After Diuretic Therapy
Neurologic Deterioration in Sinking Skin Flap Syndrome After Diuretic Therapy Open
The sinking skin flap syndrome (SSFS), or syndrome of the trephined, is a pathological condition arising from the presence of large bone defects of the skull. Originally described by Grant and Norcross in patients with a skin flap depressi…
View article: Serum BDNF Levels Are Reduced in Patients with Disorders of Consciousness and Are Not Modified by Verticalization with Robot-Assisted Lower-Limb Training
Serum BDNF Levels Are Reduced in Patients with Disorders of Consciousness and Are Not Modified by Verticalization with Robot-Assisted Lower-Limb Training Open
Little is known about plastic changes occurring in the brains of patients with severe disorders of consciousness (DOCs) caused by acute brain injuries at rest and during rehabilitative treatment. Brain-derived neurotrophic factor (BDNF) is…
View article: Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans
Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans Open
Traumatic brain injury (TBI) is the paradigmatic example of acute brain injury, defined as sudden and unexpected structural and/or functional damage to the brain. In western countries, TBI is a main cause of prolonged disability, and it is…
View article: Peer Review #1 of "Public perception of the vegetative state/unresponsive wakefulness syndrome: a crowdsourced study (v0.2)"
Peer Review #1 of "Public perception of the vegetative state/unresponsive wakefulness syndrome: a crowdsourced study (v0.2)" Open
Background:The vegetative state (VS)/unresponsive wakefulness syndrome (UWS) denotes braininjured, awake patients who are seemingly without awareness.Still, up to 15% of these patients show signs of covert consciousness when examined by fu…
View article: Peer Review #1 of "Public perception of the vegetative state/unresponsive wakefulness syndrome: a crowdsourced study (v0.1)"
Peer Review #1 of "Public perception of the vegetative state/unresponsive wakefulness syndrome: a crowdsourced study (v0.1)" Open
Background:The vegetative state (VS)/unresponsive wakefulness syndrome (UWS) denotes braininjured, awake patients who are seemingly without awareness.Still, up to 15% of these patients show signs of covert consciousness when examined by fu…
View article: A strange case of dyspnoea
A strange case of dyspnoea Open
Acquired neuralgic amyotrophy, described for the first time by Parsonage and Turner, is a rare idiopathic disease that may occur in otherwise normal healthy individuals. It typically begins with sudden, unilateral shoulder pain that may al…