Sergio Becerra
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View article: Your brain on art, nature, and meditation: a pilot neuroimaging study
Your brain on art, nature, and meditation: a pilot neuroimaging study Open
Objectives Exposure to art, nature, or meditation, all transcending human experiences, has beneficial effects on health and wellbeing. Focusing inward or watching art and nature videos elicits positive emotions that can help heal stress-re…
View article: A phase 2, open-label study of anti-inflammatory NE3107 in patients with dementias
A phase 2, open-label study of anti-inflammatory NE3107 in patients with dementias Open
Background: Alzheimer’s disease (AD) is a progressive, multifactorial, neurodegenerative disorder affecting >6 million Americans. Chronic, low-grade neuroinflammation, and insulin resistance may drive AD pathogenesis. We explored the neuro…
View article: Transcranial Focused Ultrasound Targeting the Amygdala May Increase Psychophysiological and Subjective Negative Emotional Reactivity in Healthy Older Adults
Transcranial Focused Ultrasound Targeting the Amygdala May Increase Psychophysiological and Subjective Negative Emotional Reactivity in Healthy Older Adults Open
The results of this study provide preliminary evidence that a single session of TFUS targeting the amygdala may alter psychophysiological and subjective emotional responses, indicating some potential for future neuropsychiatric application…
View article: Choosing Wisely in oncology in Latin America: what SLACOM does not recommend in the care of cancer patients in Latin America
Choosing Wisely in oncology in Latin America: what SLACOM does not recommend in the care of cancer patients in Latin America Open
Choosing Wisely is an initiative by the American Board of Internal Medicine (ABIM) and ABIM Foundation to deter unnecessary medical treatments and procedures. Faced with the burden of modern technologies and treatments, it is crucial to id…
View article: Transcranial focused ultrasound for the treatment of tremor: A preliminary case series
Transcranial focused ultrasound for the treatment of tremor: A preliminary case series Open
Preliminary findings support LIFU's safety and feasibility. The potential efficacy encourages additional sham-controlled studies.
View article: Treatment‐Induced Epigenetic Modifications in MCI and Probable Alzheimer’s Disease
Treatment‐Induced Epigenetic Modifications in MCI and Probable Alzheimer’s Disease Open
Background NE3107 is an oral small molecule, blood‐brain permeable anti‐inflammatory insulin sensitizer that binds ERK, inhibits inflammatory NFkB and TNF signaling in macrophage lineage cells, and in clinical studies for AD (NCT04669028) …
View article: A pilot study of low-intensity focused ultrasound for treatment-resistant generalized anxiety disorder
A pilot study of low-intensity focused ultrasound for treatment-resistant generalized anxiety disorder Open
NCT04250441.
View article: Functional MRI Lateralization [M1] of dlPFC and Implications for Transcranial Magnetic Stimulation (TMS) Targeting
Functional MRI Lateralization [M1] of dlPFC and Implications for Transcranial Magnetic Stimulation (TMS) Targeting Open
The present study investigates a potential method of optimizing effective strategies for the functional lateralization of the dorsolateral prefrontal cortex (dlPFC) while in a scanner. Effective hemisphere lateralization of the dlPFC is cr…
View article: Transcranial focused ultrasound selectively increases perfusion and modulates functional connectivity of deep brain regions in humans
Transcranial focused ultrasound selectively increases perfusion and modulates functional connectivity of deep brain regions in humans Open
Background Low intensity, transcranial focused ultrasound (tFUS) is a re-emerging brain stimulation technique with the unique capability of reaching deep brain structures non-invasively. Objective/Hypothesis We sought to demonstrate that t…
View article: Transcranial focused ultrasound for the treatment of tremor: a preliminary investigation
Transcranial focused ultrasound for the treatment of tremor: a preliminary investigation Open
Introduction: Treatment options for essential tremor (ET) and parkinsonian tremor (PT) are limited by reduced efficacy and the invasive nature of deep brain stimulation (DBS). Recently, the use of high-intensity focused ultrasound has show…
View article: Transcranial Infrared Laser Stimulation for the Treatment of Traumatic Brain Injury: A Case Series
Transcranial Infrared Laser Stimulation for the Treatment of Traumatic Brain Injury: A Case Series Open
Introduction: This study intended to evaluate the safety and possible therapeutic effect of transcranial infrared laser stimulation (TILS) based on photobiomodulation (PBM) among patients with traumatic brain injury (TBI). Methods: Eleven …
View article: Clinical relevance of the use of Dentoxol<sup>®</sup> for oral mucositis induced by radiotherapy: A phase II clinical trial
Clinical relevance of the use of Dentoxol<sup>®</sup> for oral mucositis induced by radiotherapy: A phase II clinical trial Open
The results of this study justify the incorporation of Dentoxol® mouth rinse into clinical protocols as a complement to cancer therapy to prevent and/or treat oral mucositis secondary to radiotherapy.
View article: Comparing therapeutic‐focused ultrasound (TFUS) in conjunction with bosutinib versus independent TFUS administration among Alzheimer’s patients
Comparing therapeutic‐focused ultrasound (TFUS) in conjunction with bosutinib versus independent TFUS administration among Alzheimer’s patients Open
Background To date, there are limited therapeutic options for the treatment or symptomatic relief of degenerative dementia [1]. There has been growing interest in the class of medications known as tyrosine kinase inhibitors, such as bosuti…
View article: A pilot study of low-intensity focused ultrasound for treatment-resistant generalized anxiety disorder
A pilot study of low-intensity focused ultrasound for treatment-resistant generalized anxiety disorder Open
Objective: This study intended to evaluate a possible therapeutic effect among patients with treatment-refractory generalized anxiety disorder (trGAD) by using transcranial focused ultrasound (tfUS) tfUS to disrupt amygdalar activity. Meth…
View article: Translating state-of-the-art brain magnetic resonance imaging (MRI) techniques into clinical practice: multimodal MRI differentiates dementia subtypes in a traditional clinical setting
Translating state-of-the-art brain magnetic resonance imaging (MRI) techniques into clinical practice: multimodal MRI differentiates dementia subtypes in a traditional clinical setting Open
Regional volumetrics, DTI metrics, and ASL successfully differentiated dementia patients from controls with sufficient sensitivity to differentiate dementia subtypes. Similarly, feature reduction results suggest that advanced analyses can …
View article: Hemispheric Dominance for Task Dependent Frontal Lobe Function &amp; Its Relationship to Language Lateralization and Handedness
Hemispheric Dominance for Task Dependent Frontal Lobe Function & Its Relationship to Language Lateralization and Handedness Open
The present study investigates a potential method to optimize effective functional localization strategies for both language regions and the dorsolateral prefrontal cortex (dlPFC) while in a scanner. This functional task combines elements …
View article: Radiotherapy for cervical cancer: Chilean consensus of the Society of Radiation Oncology
Radiotherapy for cervical cancer: Chilean consensus of the Society of Radiation Oncology Open
BACKGROUND: Cervical cancer is a public health problem in Latin America. Radiotherapy plays a fundamental role both as definitive or adjuvant treatment. There are important intra and inter-country differences regarding access and availabil…
View article: Treatment of Dementia With Bosutinib
Treatment of Dementia With Bosutinib Open
Results support an overall positive outcome after 1 year of bosutinib. Future studies should explore the relationship between tyrosine kinases and neurodegenerative pathology as well as related avenues of treatment.
View article: Safety of Focused Ultrasound Neuromodulation in Humans with Temporal Lobe Epilepsy
Safety of Focused Ultrasound Neuromodulation in Humans with Temporal Lobe Epilepsy Open
Objective Low-Intensity Focused Ultrasound Pulsations (LIFUP) is a promising new potential neuromodulation tool. However, the safety of LIFUP neuromodulation has not yet been adequately assessed. Patients with refractory temporal lobe epil…
View article: Efficacy and safety of Dentoxol® in the prevention of radiation-induced oral mucositis in head and neck cancer patients (ESDOM): a randomized, multicenter, double-blind, placebo-controlled, phase II trial
Efficacy and safety of Dentoxol® in the prevention of radiation-induced oral mucositis in head and neck cancer patients (ESDOM): a randomized, multicenter, double-blind, placebo-controlled, phase II trial Open
Purpose The aim of this study was to assess the efficacy and safety of Dentoxol mouthrinse in reducing the severity of oral mucositis (OM) secondary to radiation therapy (RT) for head and neck cancer. Methods A randomized, double-blind, pl…