Sérgio L. Cravo
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View article: Energy Intake Equalization During Pregnancy of Obese Mothers: Efects on the Maternal Energy Balance and Fetal Development
Energy Intake Equalization During Pregnancy of Obese Mothers: Efects on the Maternal Energy Balance and Fetal Development Open
OBJECTIVE: The effects of maternal obesity on fetal development are controversial. Our aim was to evaluate the effects of energy intake equalization during pregnancy on the maternal energy balance and fetal development. METHODS: Female rat…
View article: Cardiac and Autonomic Dysfunctions Assessed Through Recurrence Quantitative Analysis of Electrocardiogram Signals and an Application to the 6-Hydroxydopamine Parkinson’s Disease Animal Model
Cardiac and Autonomic Dysfunctions Assessed Through Recurrence Quantitative Analysis of Electrocardiogram Signals and an Application to the 6-Hydroxydopamine Parkinson’s Disease Animal Model Open
A classic method to evaluate autonomic dysfunction is through the evaluation of heart rate variability (HRV). HRV provides a series of coefficients, such as Standard Deviation of n-n intervals (SDNN) and Root Mean Square of Successive Diff…
View article: Cardiac and autonomic dysfunctions assessed through Recurrence Quantitative Analysis of electrocardiogram signals and an application to the 6-OHDA Parkinson’s Disease animal model
Cardiac and autonomic dysfunctions assessed through Recurrence Quantitative Analysis of electrocardiogram signals and an application to the 6-OHDA Parkinson’s Disease animal model Open
A classic method to evaluate autonomic dysfunction is through the evaluation of heart rate variability (HRV). HRV provides a series of coefficients, such as SDNN (Standard Deviation of n-n intervals) and RMSSD (Root Mean Square of Successi…
View article: Chronic apnea during REM sleep increases arterial pressure and sympathetic modulation in rats
Chronic apnea during REM sleep increases arterial pressure and sympathetic modulation in rats Open
Study Objectives Obstructive sleep apnea can induce hypertension. Apneas in REM may be particularly problematic: they are independently associated with hypertension. We examined the role of sleep stage and awakening on acute cardiovascular…
View article: Increased sympathetic responses induced by chronic obstructive sleep apnea are caused by sleep fragmentation
Increased sympathetic responses induced by chronic obstructive sleep apnea are caused by sleep fragmentation Open
Obstructive sleep apnea causes a hyperactive chemoreflex, with increased sympathetic activation. However, it is not clear whether this pathophysiologic mechanism is due to repeated hypoxia or to sleep disruption. The present study suggests…
View article: Carotid chemoreflex activity restrains post‐exercise cardiac autonomic control in healthy humans and in patients with pulmonary arterial hypertension
Carotid chemoreflex activity restrains post‐exercise cardiac autonomic control in healthy humans and in patients with pulmonary arterial hypertension Open
Key points Dysfunction of post‐exercise cardiac autonomic control is associated with increased mortality risk in healthy adults and in patients with cardiorespiratory diseases. The afferent mechanisms that regulate the post‐exercise cardia…
View article: Airway obstruction produces widespread sympathoexcitation: role of hypoxia, carotid chemoreceptors, and NTS neurotransmission
Airway obstruction produces widespread sympathoexcitation: role of hypoxia, carotid chemoreceptors, and NTS neurotransmission Open
Obstructive sleep apnea (OSA) is the most common respiratory disturbance of sleep and is closely associated to cardiovascular diseases. In humans, apnea increases respiratory effort and elevates muscle sympathetic nerve activity (SNA), but…
View article: Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea
Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea Open
Obstructive sleep apnea (OSA) is known to be independently associated with several cardiovascular diseases including hypertension, myocardial infarction, and stroke. To determine how OSA can increase cardiovascular risk, animal models have…