Sergio E. Chiarella
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View article: Advances in Automated Fetal Brain MRI Segmentation and Biometry: Insights from the FeTA 2024 Challenge
Advances in Automated Fetal Brain MRI Segmentation and Biometry: Insights from the FeTA 2024 Challenge Open
Accurate fetal brain tissue segmentation and biometric analysis are essential for studying brain development in utero. The FeTA Challenge 2024 advanced automated fetal brain MRI analysis by introducing biometry prediction as a new task alo…
View article: Adverse effects of biologics used to treat asthma
Adverse effects of biologics used to treat asthma Open
In this review, we discuss the risks and adverse effects reported for the current Food and Drug Association (FDA)-approved biologics used in the management of asthma, including omalizumab, benralizumab, dupilumab, mepolizumab, reslizumab, …
View article: Aspirin-exacerbated respiratory disease is associated with variants in filaggrin, epithelial integrity, and cellular interactions
Aspirin-exacerbated respiratory disease is associated with variants in filaggrin, epithelial integrity, and cellular interactions Open
WES identified a monogenic susceptibility to AERD in 5% of patients with FLG pathogenic variants. Other variants not previously identified as pathogenic were found in genes relevant to epithelial integrity and cellular interactions and may…
View article: Sex differences in a murine model of asthma are time and tissue compartment dependent
Sex differences in a murine model of asthma are time and tissue compartment dependent Open
Asthma is a sexually dimorphic disease with greater documented prevalence and severity in women compared to men. Immunological parameters in mouse models of asthma also exhibit sexual dimorphism, with female mice typically having higher Th…
View article: Hypersensitivity reactions to biologics used in the treatment of allergic diseases: clinical features, diagnosis and management
Hypersensitivity reactions to biologics used in the treatment of allergic diseases: clinical features, diagnosis and management Open
Several monoclonal antibodies have been approved by the Food and Drug Administration (FDA) to treat allergic disorders, including omalizumab, dupilumab, mepolizumab, reslizumab, benralizumab, tralokinumab and tezepelumab, and their indicat…
View article: Endogenous inhibitory mechanisms in asthma
Endogenous inhibitory mechanisms in asthma Open
Endogenous inhibitory mechanisms promote resolution of inflammation, enhance tissue repair and integrity, and promote homeostasis in the lung. These mechanisms include steroid hormones, regulatory T cells, IL-10, prostaglandin E2, prostagl…
View article: Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study
Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study Open
Introduction: Nitrogen dioxide (NO 2 ) is known to be a trigger for asthma exacerbation. However, little is known about the role of seasonal variation in indoor and outdoor NO 2 levels in childhood asthma in a mixed rural-urban setting of …
View article: Asthma in pregnancy
Asthma in pregnancy Open
Background: Asthma is a frequent and potentially life-threatening disease that complicates many pregnancies. There are extensive data with regard to the diagnosis and treatment of asthma during pregnancy. Medical providers require an up-to…
View article: Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions
Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions Open
The adherens junction component, alpha-T-catenin (αTcat) is an established contributor to cardiomyocyte junction structure and function, but recent genomic studies link CTNNA3 polymorphisms to diseases with no clear cardiac underpinning, i…
View article: Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions
Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions Open
The adherens junction component, alpha-T-catenin (αTcat) is an established contributor to cardiomyocyte junction structure and function, but recent genomic studies link CTNNA3 polymorphisms to diseases with no clear cardiac underpinning, i…
View article: Genomic evidence for dysregulated glutamine metabolism in the asthmatic airway epithelium
Genomic evidence for dysregulated glutamine metabolism in the asthmatic airway epithelium Open
Airway epithelial cells (AECs) play a critical role in lung tissue homeostasis and disease. In asthma, AECs can promote the development of airway inflammation and remodeling through the secretion and regulation of a wide array of mediators…