Sergio Fantini
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View article: Special Topic: Photonics in biomedicine
Special Topic: Photonics in biomedicine Open
View article: Influence of Uncertainties in Optode Positions on Self-Calibrating or Dual-Slope Diffuse Optical Measurements
Influence of Uncertainties in Optode Positions on Self-Calibrating or Dual-Slope Diffuse Optical Measurements Open
Self-calibrating and dual-slope measurements have been used in the field of diffuse optics for robust assessment of absolute values or temporal changes in the optical properties of highly scattering media and biological tissue. These measu…
View article: Critical analysis of the relationship between arterial saturation and the ratio-of-ratios used in pulse oximetry
Critical analysis of the relationship between arterial saturation and the ratio-of-ratios used in pulse oximetry Open
The analysis reported here clarifies the source of the calibration equations used in pulse oximetry and provides guidance to assess the impact of various key optical parameters on the accuracy of pulse oximetry.
View article: The fNIRS Glossary Project: A Consensus-based Resource for Functional Near-Infrared Spectroscopy Terminology
The fNIRS Glossary Project: A Consensus-based Resource for Functional Near-Infrared Spectroscopy Terminology Open
Significance A shared understanding of terminology is essential for clear scientific communication and minimizing misconceptions. This is particularly challenging in rapidly expanding, interdisciplinary domains that utilize functional near…
View article: Dual-ratio approach to pulse oximetry and the effect of skin tone
Dual-ratio approach to pulse oximetry and the effect of skin tone Open
For the models and methods considered here, measurements are strongly impacted by heterogeneous pulsatile hemodynamics. This variability may be larger than the skin tone bias, which is a known confound in measurements. The partial …
View article: Dual-ratio approach to pulse oximetry and the effect of skin tone
Dual-ratio approach to pulse oximetry and the effect of skin tone Open
Significance: Pulsatile blood Oxygen Saturation (SpO2 ) via pulse oximetry is a valuable clinical metric for assessing oxygen delivery. Individual anatomical features, including skin tone, may affect current optical pulse oximetry methods.…
View article: Spatial sensitivity to absorption changes for various near-infrared spectroscopy methods: A compendium review
Spatial sensitivity to absorption changes for various near-infrared spectroscopy methods: A compendium review Open
This compendium review focuses on the spatial distribution of sensitivity to localized absorption changes in optically diffuse media, particularly for measurements relevant to near-infrared spectroscopy. The three temporal domains, continu…
View article: Single-distance and dual-slope frequency-domain near-infrared spectroscopy to assess skeletal muscle hemodynamics
Single-distance and dual-slope frequency-domain near-infrared spectroscopy to assess skeletal muscle hemodynamics Open
The dataset generated by DS FD-NIRS may allow for discrimination of superficial and deep absorption changes in two-layered media, thus lending itself to individual measurements of hemodynamics in adipose and muscle tissue.
View article: Introduction to Special Issue on Neurophotonics
Introduction to Special Issue on Neurophotonics Open
Optoelectronics, genomics, and proteomics have ushered in an era of new approaches and tools for neuroscience research, especially optical neuroimaging.\Function follows form", anatomical structure is the basis for understanding brain func…
View article: Spatial Sensitivity to Absorption Changes for Various Near-Infrared Spectroscopy Methods: A Compendium Review
Spatial Sensitivity to Absorption Changes for Various Near-Infrared Spectroscopy Methods: A Compendium Review Open
This compendium review focuses on the spatial distribution of sensitivity to localized absorption changes in optically diffuse media, particularly for measurements relevant to near-infrared spectroscopy. The three temporal domains, continu…
View article: Dual-ratio approach for detection of point fluorophores in biological tissue
Dual-ratio approach for detection of point fluorophores in biological tissue Open
DR cancelable noise may be designed (e.g., through the use of source multiplexing), and indications point to the AF contributors' distribution being truly surface-weighted in vivo. Successful and worthwhile implementation of DR DiFC…
View article: Dual-ratio approach for detection of point fluorophores in biological tissue
Dual-ratio approach for detection of point fluorophores in biological tissue Open
Significance: Diffuse in-vivo Flow Cytometry (DiFC) is an emerging fluorescence sensing method to non-invasively detect labeled circulating cells in-vivo. However, due to Signal-to-Noise Ratio (SNR) constraints largely attributed to backgr…
View article: Shrub Cover and Soil Moisture Affect Taxus baccata L. Regeneration at Its Southern Range
Shrub Cover and Soil Moisture Affect Taxus baccata L. Regeneration at Its Southern Range Open
The effect of key ecological and anthropic factors on the recruitment of the common yew (Taxus baccata L.) in Sardinia (Italy) has been analyzed. After bibliographic and cartographic research, followed by field surveys, we found 232 sites …
View article: Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy
Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy Open
DS imaging with FD NIRS may suppress confounding contributions from superficial hemodynamics without relying on data at short source-detector distances. This capability can have significant implications for non-invasive optical measurement…
View article: Shrub cover and soil moisture affect Taxus baccata L. regeneration at its southern range
Shrub cover and soil moisture affect Taxus baccata L. regeneration at its southern range Open
The effect of key ecological and anthropic factors on recruitment of the common yew ( Taxus baccata ) in Sardinia (Italy) has been analysed. After a bibliographic and cartographic research, followed by field surveys, we found 232 sites whe…
View article: Method for Measuring Absolute Optical Properties of Turbid Samples in a Standard Cuvette
Method for Measuring Absolute Optical Properties of Turbid Samples in a Standard Cuvette Open
Many applications seek to measure a sample's absorption coefficient spectrum to retrieve the chemical makeup. Many real world samples are optically turbid, causing scattering confounds which many commercial spectrometers cannot address. Us…
View article: Optical imaging and spectroscopy for the study of the human brain: status report
Optical imaging and spectroscopy for the study of the human brain: status report Open
This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit of novel methods to explore brain health and function. While the first report focused on neurophotonic tools mostly appli…
View article: Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy
Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy Open
Significance: This work targets the contamination of optical signals by superficial hemodynamics, which is one of the chief hurdles in non-invasive optical measurements of the human brain. Aim: To identify optimal source-detector distances…
View article: Incorporating the visibility analysis of fire lookouts for old-growth wood fire risk reduction in the Mediterranean island of Sardinia
Incorporating the visibility analysis of fire lookouts for old-growth wood fire risk reduction in the Mediterranean island of Sardinia Open
Sardinia is subject to many fire events each year. A visibility analysis of old-growth woods from the network of fire lookouts was performed; the visibility of fires from lookouts and the level of old-growthness of woods were then implemen…
View article: Noninvasive Optical Measurements of Dynamic Cerebral Autoregulation by Inducing Oscillatory Cerebral Hemodynamics
Noninvasive Optical Measurements of Dynamic Cerebral Autoregulation by Inducing Oscillatory Cerebral Hemodynamics Open
Objective: Cerebral autoregulation limits the variability of cerebral blood flow (CBF) in the presence of systemic arterial blood pressure (ABP) changes. Monitoring cerebral autoregulation is important in the Neurocritical Care Unit (NCCU)…
View article: Positive interactions between great longhorn beetles and forest structure
Positive interactions between great longhorn beetles and forest structure Open
View article: Domain adaptation for robust workload level alignment between sessions and subjects using fNIRS
Domain adaptation for robust workload level alignment between sessions and subjects using fNIRS Open
Domain adaptation has potential for session-by-session and subject-by-subject alignment of mental workload by using fNIRS data.
View article: Structural heterogeneity and old-growthness: A first regional-scale assessment of Sardinian forests
Structural heterogeneity and old-growthness: A first regional-scale assessment of Sardinian forests Open
Mediterranean forests have been altered by several human activities. Consequently, relatively intact forests that have been unmodified by humans for a relatively long time (i.e., old-growth forests) are often reduced to isolated and fragme…
View article: Domain Adaptation for Robust Workload Classification using fNIRS.
Domain Adaptation for Robust Workload Classification using fNIRS. Open
Significance: We demonstrated the potential of using domain adaptation on functional Near-Infrared Spectroscopy (fNIRS) data to detect and discriminate different levels of n-back tasks that involve working memory across different experimen…
View article: Frequency-Domain Techniques for Cerebral and Functional Near-Infrared Spectroscopy
Frequency-Domain Techniques for Cerebral and Functional Near-Infrared Spectroscopy Open
This article reviews the basic principles of frequency-domain near-infrared spectroscopy (FD-NIRS), which relies on intensity-modulated light sources and phase-sensitive optical detection, and its non-invasive applications to the brain. Th…
View article: Depth dependence of coherent hemodynamics in the human head
Depth dependence of coherent hemodynamics in the human head Open
We report a near-infrared spectroscopy (NIRS) study of coherent hemodynamic oscillations measured on the human forehead at multiple source-detector distances (1 to 4 cm). The physiological source of the coherent hemodynamics is arterial bl…
View article: Low-resolution mapping of the effective attenuation coefficient of the human head: a multidistance approach applied to high-density optical recordings
Low-resolution mapping of the effective attenuation coefficient of the human head: a multidistance approach applied to high-density optical recordings Open
Near infrared (NIR) light has been widely used for measuring changes in hemoglobin concentration in the human brain (functional NIR spectroscopy, fNIRS). fNIRS is based on the differential measurement and estimation of absorption perturbat…
View article: Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods
Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods Open
Cerebral blood flow (CBF) and cerebral autoregulation (CA) are critically important to maintain proper brain perfusion and supply the brain with the necessary oxygen and energy substrates. Adequate brain perfusion is required to support no…
View article: Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain
Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain Open
We present a near-infrared spectroscopy (NIRS) study of local hemodynamics in the breast and the brain (prefrontal cortex) of healthy volunteers in a protocol involving periodic perturbations to the systemic arterial blood pressure. These …
View article: Optical oximetry of volume-oscillating vascular compartments: contributions from oscillatory blood flow
Optical oximetry of volume-oscillating vascular compartments: contributions from oscillatory blood flow Open
We present a quantitative analysis of dynamic diffuse optical measurements to obtain oxygen saturation of hemoglobin in volume oscillating compartments. We used a phasor representation of oscillatory hemodynamics at the heart rate and resp…