Petra Martini
YOU?
Author Swipe
View article: 68Ga-Trivehexin: Current Status of αvβ6-Integrin Imaging and Perspectives
68Ga-Trivehexin: Current Status of αvβ6-Integrin Imaging and Perspectives Open
Background/Objectives: Molecular imaging, especially PET, has advanced significantly, shifting from metabolic radiotracers like 2-deoxy-2-[18F]fluoro-D-glucose [18F]FDG to target-specific probes. Among these, αvβ6-integrin has emerged as a…
View article: Spark plasma sintering in manufacturing and recycling of ZnO targets for medical radioisotopes cyclotron-based production
Spark plasma sintering in manufacturing and recycling of ZnO targets for medical radioisotopes cyclotron-based production Open
This work reports on the successful use of the Spark Plasma Sintering (SPS) process for the densification of the zinc oxide (ZnO) powder (<5 μm size) to manufacture solid thick targets for cyclotron-based production of radionuclides. The c…
View article: Recent Advances in Preclinical Studies of the Theranostic Agent [64Cu]CuCl2
Recent Advances in Preclinical Studies of the Theranostic Agent [64Cu]CuCl2 Open
64Cu is gaining recognition not only for its diagnostic capabilities in nuclear medical imaging but also for its therapeutic and theranostic potential. The simultaneous βˉ and Auger emissions of 64Cu can be utilized to induce a therapeutic…
View article: Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging
Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging Open
Background The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven production of 52 Mn for…
View article: Manganese-Loaded Liposomes: An In Vitro Study for Possible Diagnostic Application
Manganese-Loaded Liposomes: An In Vitro Study for Possible Diagnostic Application Open
The present study investigates the possible use of manganese (Mn)-based liposomal formulations for diagnostic applications in imaging techniques such as magnetic resonance imaging (MRI), with the aim of overcoming the toxicity limitations …
View article: Research on Emerging Medical radionuclides from the X-sections (REMIX): The Accelerator-based Production of <sup>47</sup>Sc, <sup>149</sup>Tb, <sup>152</sup>Tb, <sup>155</sup>Tb and <sup>161</sup>Tb
Research on Emerging Medical radionuclides from the X-sections (REMIX): The Accelerator-based Production of <sup>47</sup>Sc, <sup>149</sup>Tb, <sup>152</sup>Tb, <sup>155</sup>Tb and <sup>161</sup>Tb Open
The REMIX project is focused on the cyclotron-based production of 47 Sc, 149 Tb, 152 Tb, 155 Tb and 161 Tb radionuclides, whose decay characteristics make them suitable for medical applications. This work will outline the main results achi…
View article: Oldie but Goodie: Is Technetium-99m Still a Treasure Trove of Innovation for Medicine? A Patents Analysis (2000–2022)
Oldie but Goodie: Is Technetium-99m Still a Treasure Trove of Innovation for Medicine? A Patents Analysis (2000–2022) Open
Technetium-99m is the workhorse of diagnostic nuclear medicine. The aim of the work is to analyze the technetium-99m patents since 2000 to photograph its innovation. QUESTEL's ORBIT Intelligence system was used for the collection of techne…
View article: Metal-Based Radiopharmaceuticals in Inorganic Chemistry
Metal-Based Radiopharmaceuticals in Inorganic Chemistry Open
The field of radiopharmaceuticals is constantly evolving thanks to the great contribution of specialists coming from different disciplines such as inorganic chemistry, radiochemistry, organic and biochemistry, pharmacology, nuclear medicin…
View article: Development and Evaluation of the Magnetic Properties of a New Manganese (II) Complex: A Potential MRI Contrast Agent
Development and Evaluation of the Magnetic Properties of a New Manganese (II) Complex: A Potential MRI Contrast Agent Open
Magnetic resonance imaging (MRI) is a non-invasive powerful modern clinical technique that is extensively used for the high-resolution imaging of soft tissues. To obtain high-definition pictures of tissues or of the whole organism this tec…
View article: Development of a new class of Mn(II) complexes for MRI applications
Development of a new class of Mn(II) complexes for MRI applications Open
The aim of this work is to develop a new class of Mn(II)-dithiocarbamates complexes potentially used as magnetic resonance imaging contrast media. This work was born within the METRICS project (acronym for Multimodal pET/mRi Imaging with C…
View article: Rhenium Radioisotopes for Medicine, a Focus on Production and Applications
Rhenium Radioisotopes for Medicine, a Focus on Production and Applications Open
In recent decades, the use of alpha; pure beta; or beta/gamma emitters in oncology, endocrinology, and interventional cardiology rheumatology, has proved to be an important alternative to the most common therapeutic regimens. Among radionu…
View article: Synthetic and Nanotechnological Approaches for a Diagnostic Use of Manganese
Synthetic and Nanotechnological Approaches for a Diagnostic Use of Manganese Open
The development of multimodal imaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) allows the contemporary obtaining of metabolic and morphological information. To fully exploit the complementa…
View article: 67Cu Production Capabilities: A Mini Review
67Cu Production Capabilities: A Mini Review Open
Is the 67Cu production worldwide feasible for expanding preclinical and clinical studies? How can we face the ingrowing demands of this emerging and promising theranostic radionuclide for personalized therapies? This review looks at the di…
View article: Technetium-99m Radiopharmaceuticals for Ideal Myocardial Perfusion Imaging: Lost and Found Opportunities
Technetium-99m Radiopharmaceuticals for Ideal Myocardial Perfusion Imaging: Lost and Found Opportunities Open
The favorable nuclear properties in combination with the rich coordination chemistry make technetium-99m the radioisotope of choice for the development of myocardial perfusion tracers. In the early 1980s, [99mTc]Tc-Sestamibi, [99mTc]Tc-Tet…
View article: A Universal Cassette-Based System for the Dissolution of Solid Targets
A Universal Cassette-Based System for the Dissolution of Solid Targets Open
Cyclotron-based radionuclides production by using solid targets has become important in the last years due to the growing demand of radiometals, e.g., 68Ga, 89Zr, 43/47Sc, and 52/54Mn. This shifted the focus on solid target management, whe…
View article: Synthesis and Characterization of Manganese Dithiocarbamate Complexes: New Evidence of Dioxygen Activation
Synthesis and Characterization of Manganese Dithiocarbamate Complexes: New Evidence of Dioxygen Activation Open
(1) Background: Metal dithiocarbamate compounds have long been the subject of research due to their ease of formation, excellent properties and potential applications. However, manganese complexes with dithiocarbamates, to our knowledge, h…
View article: Highly Efficient Micro-Scale Liquid-Liquid In-Flow Extraction of 99mTc from Molybdenum
Highly Efficient Micro-Scale Liquid-Liquid In-Flow Extraction of 99mTc from Molybdenum Open
The trend to achieve even more compact-sized systems is leading to the development of micro-scale reactors (lab-on-chip) in the field of radiochemical separation and radiopharmaceutical production. Technetium-99m extraction from both high …
View article: 90Y/177Lu-DOTATOC: From Preclinical Studies to Application in Humans
90Y/177Lu-DOTATOC: From Preclinical Studies to Application in Humans Open
The PRRT (Peptide Receptor Radionuclide Therapy) is a promising modality treatment for patients with inoperable or metastatic neuroendocrine tumors (NETs). Progression-free survival (PFS) and overall survival (OS) of these patients are fav…
View article: Production of <sup>67</sup>Cu by enriched <sup>70</sup>Zn targets: first measurements of formation cross sections of <sup>67</sup>Cu, <sup>64</sup>Cu, <sup>67</sup>Ga, <sup>66</sup>Ga, <sup>69m</sup>Zn and <sup>65</sup>Zn in interactions of <sup>70</sup>Zn with protons above 45 MeV
Production of <sup>67</sup>Cu by enriched <sup>70</sup>Zn targets: first measurements of formation cross sections of <sup>67</sup>Cu, <sup>64</sup>Cu, <sup>67</sup>Ga, <sup>66</sup>Ga, <sup>69m</sup>Zn and <sup>65</sup>Zn in interactions of <sup>70</sup>Zn with protons above 45 MeV Open
Despite its insufficient availability, Copper-67 is currently attracting much attention for its enormous potential for cancer therapy as theranostic radionuclide. This work aims to accurately measure the unexplored cross section 70 Zn(p,x)…
View article: A Picture of Modern Tc-99m Radiopharmaceuticals: Production, Chemistry, and Applications in Molecular Imaging
A Picture of Modern Tc-99m Radiopharmaceuticals: Production, Chemistry, and Applications in Molecular Imaging Open
Even today, techentium-99m represents the radionuclide of choice for diagnostic radio-imaging applications. Its peculiar physical and chemical properties make it particularly suitable for medical imaging. By the use of molecular probes and…
View article: Correction: Uccelli, L., et al. Therapeutic Radiometals: Worldwide Scientific Literature Trend Analysis (2008–2018). Molecules 2019, 24, 640
Correction: Uccelli, L., et al. Therapeutic Radiometals: Worldwide Scientific Literature Trend Analysis (2008–2018). Molecules 2019, 24, 640 Open
The authors wish to make the following corrections to their paper [...]
View article: Recovery of Molybdenum Precursor Material in the Cyclotron-Based Technetium-99m Production Cycle
Recovery of Molybdenum Precursor Material in the Cyclotron-Based Technetium-99m Production Cycle Open
A closed-loop technology aiming at recycling the highly 100Mo-enriched molybdenum target material has been developed in the framework of the international research efforts on the alternative, cyclotron-based 99mTc radionuclide production. …