Sergio Oddi
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View article: Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s disease
Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive and non-cognitive decline associated with neuropathological hallmarks, including neuroinflammation. Palmitoylethanolamide (PEA), an endogenous …
View article: Fatty‐acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosis
Fatty‐acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosis Open
The endocannabinoid N ‐arachidonoylethanolamine (AEA) is a pro‐homeostatic bioactive lipid known for its anti‐inflammatory, anti‐oxidative, immunomodulatory, and neuroprotective properties, which may contrast/mitigate Alzheimer's disease (…
View article: Probing Native CB<sub>2</sub> Receptor Mobility in Plasma Membranes of Living Cells by Fluorescence Recovery After Photobleaching
Probing Native CB<sub>2</sub> Receptor Mobility in Plasma Membranes of Living Cells by Fluorescence Recovery After Photobleaching Open
In this study, we employed a novel fluorescent probe, RO7304924 – which selectively targets cannabinoid 2 receptor (CB 2 R) – to assess the lateral mobility of CB 2 R within the plasma membrane of Chinese hamster ovary cells stably express…
View article: Alterations of endocannabinoid signaling and microglia reactivity in the retinas of <scp>AD</scp> ‐like mice precede the onset of hippocampal β‐amyloid plaques
Alterations of endocannabinoid signaling and microglia reactivity in the retinas of <span>AD</span> ‐like mice precede the onset of hippocampal β‐amyloid plaques Open
Extra‐cerebral manifestations of Alzheimer's disease (AD) develop in the retina, which is, therefore, considered a “window to the brain”. Recent studies demonstrated the dysregulation of the endocannabinoid (eCB) system (ECS) in AD brain. …
View article: Corrigendum to “Non-enzymatic cholesterol biosensor: Electrochemical sensing based on peptide-polylactic acid thin film” [Int. J. Biol. Macromol. 281 (2024) 136337]
Corrigendum to “Non-enzymatic cholesterol biosensor: Electrochemical sensing based on peptide-polylactic acid thin film” [Int. J. Biol. Macromol. 281 (2024) 136337] Open
Corrigendum to the article "Non-enzymatic cholesterol biosensor: Electrochemical sensing based on peptide-polylactic acid thin film"
View article: Innovative Peptide-Based Plasmonic Optical Biosensor for the Determination of Cholesterol
Innovative Peptide-Based Plasmonic Optical Biosensor for the Determination of Cholesterol Open
Plasmonic-based biosensors have gained prominence as potent optical biosensing platforms in both scientific and medical research, attributable to their enhanced sensitivity and precision in detecting biomolecular and chemical interactions.…
View article: FAAH Inhibition Counteracts Neuroinflammation via Autophagy Recovery in AD Models
FAAH Inhibition Counteracts Neuroinflammation via Autophagy Recovery in AD Models Open
Endocannabinoids have attracted great interest for their ability to counteract the neuroinflammation underlying Alzheimer’s disease (AD). Our study aimed at evaluating whether this activity was also due to a rebalance of autophagic mechani…
View article: Innovative Peptide-Based Plasmonic Optical Biosensor for the Determination of Cholesterol
Innovative Peptide-Based Plasmonic Optical Biosensor for the Determination of Cholesterol Open
Plasmonic-based biosensors have gained prominence as potent optical biosensing platforms in both scientific and medical research, attributable to their enhanced sensitivity and precision in detecting biomolecular and chemical interactions.…
View article: Non-enzymatic cholesterol biosensor: Electrochemical sensing based on peptide-polylactic acid thin film
Non-enzymatic cholesterol biosensor: Electrochemical sensing based on peptide-polylactic acid thin film Open
Cholesterol is a fundamental lipid prevalent in eukaryotic cell membranes and circulating in the bloodstream bound to lipoproteins. It serves as a precursor to steroid hormones and is regarded as a biomarker for cardiovascular disease and …
View article: Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects
Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects Open
The endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating k…
View article: Combination of Hydrolysable Tannins and Zinc Oxide on Enterocyte Functionality: In Vitro Insights
Combination of Hydrolysable Tannins and Zinc Oxide on Enterocyte Functionality: In Vitro Insights Open
The management of gastrointestinal disease in animals represents a significant challenge in veterinary and zootechnic practice. Traditionally, acute symptoms have been treated with antibiotics and high doses of zinc oxide (ZnO). However, c…
View article: The endocannabinoid anandamide activates pro‐resolving pathways in human primary macrophages by engaging both <scp> CB <sub>2</sub> </scp> and <scp>GPR18</scp> receptors
The endocannabinoid anandamide activates pro‐resolving pathways in human primary macrophages by engaging both <span> CB <sub>2</sub> </span> and <span>GPR18</span> receptors Open
Resolution of inflammation is the cellular and molecular process that protects from widespread and uncontrolled inflammation and restores tissue function in the aftermath of acute immune events. This process is orchestrated by specialized …
View article: Combination of Hydrolysable Tannins and Zinc Oxide on Enterocyte Functionality: In Vitro Insights
Combination of Hydrolysable Tannins and Zinc Oxide on Enterocyte Functionality: In Vitro Insights Open
In the symptomatic treatment of gastrointestinal disorders, high dosages of zinc oxide (ZnO) were conventionally employed. However, concerns regarding the potential for microbial resistance and ecological detriment have arisen due to the e…
View article: Visualization of membrane localization and functional state of CB2R pools by matched agonist and inverse agonist probe pairs
Visualization of membrane localization and functional state of CB2R pools by matched agonist and inverse agonist probe pairs Open
The diversity of physiological roles of the endocannabinoid system has turned it into an attractive yet elusive therapeutic target. However, chemical probes with various functionalities could pave the way for a better understanding of the …
View article: Visualization of membrane localization and the functional state of CB<sub>2</sub>R pools using matched agonist and inverse agonist probe pairs
Visualization of membrane localization and the functional state of CB<sub>2</sub>R pools using matched agonist and inverse agonist probe pairs Open
Selective visualization of the active and inactive states of CB 2 R by a matched fluorescent agonist and inverse agonist probe pair.
View article: Effects of Long-Term Oral Administration of N-Palmitoylethanolamine in Subjects with Mild Cognitive Impairment: Study Protocol
Effects of Long-Term Oral Administration of N-Palmitoylethanolamine in Subjects with Mild Cognitive Impairment: Study Protocol Open
N-palmitoylethanolamine (PEA) plays a key role in preventing Aβ-mediated neuroinflammation and neurotoxicity in murine models. It has been demonstrated that PEA provides anti-neuroinflammatory, pain-relieving and neuroprotective actions ev…
View article: Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance
Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance Open
Dysfunctional phenotype of microglia, the primary brain immune cells, may aggravate Alzheimer’s disease (AD) pathogenesis by releasing proinflammatory factors, such as nitric oxide (NO). The endocannabinoids N-arachidonoylethanolamine (AEA…
View article: Determination of endocannabinoids and their conjugated congeners in the brain by means of μSPE combined with UHPLC-MS/MS
Determination of endocannabinoids and their conjugated congeners in the brain by means of μSPE combined with UHPLC-MS/MS Open
The present study encompasses the development of a fast and reliable analytical method to quantify the main endocannabinoids and some of their conjugated congeners, particularly N-arachidonoyl amino acids, in brain tissue. Samples were hom…
View article: The appearance of phagocytic microglia in the postnatal brain of Niemann Pick type C mice is developmentally regulated and underscores shortfalls in fine odor discrimination
The appearance of phagocytic microglia in the postnatal brain of Niemann Pick type C mice is developmentally regulated and underscores shortfalls in fine odor discrimination Open
The loss of NPC1 or NPC2 function results in cholesterol and sphingolipid dyshomeostasis that impairs developmental trajectories, predisposing the postnatal brain to the appearance of pathological signs, including progressive and stereotyp…
View article: Microglial Endocannabinoid Signalling in AD
Microglial Endocannabinoid Signalling in AD Open
Chronic inflammation in Alzheimer’s disease (AD) has been recently identified as a major contributor to disease pathogenesis. Once activated, microglial cells, which are brain-resident immune cells, exert several key actions, including pha…
View article: Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe
Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe Open
Detection and visualization of the cannabinoid receptor type 2 by a cell-permeable high affinity fluorescent probe platform enables tracing receptor trafficking in live cells and in zebrafish.
View article: Cryotolerance of equine spermatozoa correlates with specific fatty acid pattern: A pilot study
Cryotolerance of equine spermatozoa correlates with specific fatty acid pattern: A pilot study Open
Sperm cryopreservation represents a powerful tool for horse breeding. To improve the efficiency of artificial insemination in the horse using cryopreserved spermatozoa, an adequate understanding of the underlying biophysical properties tha…
View article: Circulating Endocannabinoids as Diagnostic Markers of Canine Chronic Enteropathies: A Pilot Study
Circulating Endocannabinoids as Diagnostic Markers of Canine Chronic Enteropathies: A Pilot Study Open
Chronic enteropathies (CEs) in dogs, according to the treatment response to consecutive trials, are classified as food-responsive (FRE), antibiotic-responsive (ARE), and immunosuppressive-responsive (IRE) enteropathy. In addition to this c…
View article: Circulating Endocannabinoids as Diagnostic Markers of Canine Chronic Enteropathies: A Pilot Study
Circulating Endocannabinoids as Diagnostic Markers of Canine Chronic Enteropathies: A Pilot Study Open
Chronic enteropathies (CEs) in dogs, according to the treatment response to consecutive trials, are classified as food-responsive (FRE), antibiotic-responsive (ARE), and immunosuppressive-responsive (IRE) enteropathy. In addition to this c…
View article: Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer's Disease Patients
Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer's Disease Patients Open
Growing evidence shows that the immune system is critically involved in Alzheimer’s disease (AD) pathogenesis and progression. The modulation and targeting of peripheral immune mechanisms are thus promising therapeutic or preventive strate…
View article: Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer’s Disease Patients
Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer’s Disease Patients Open
Growing evidence shows that the immune system is critically involved in Alzheimer’s disease (AD) pathogenesis and progression. The modulation and targeting of peripheral immune mechanisms are thus promising therapeutic or preventive strate…