Explanipedia

Single cell transcriptomics in a treatment-segregated cohort exposes a STAT3-regulated therapeutic gap in idiopathic pulmonary fibrosis Open

Neil J. McKenna, Scott A. Ochsner, Alan Waich, Juan Cala-García, Maria E. Ruiz Echartrea , et al. · 2025

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic pulmonary disease with unknown etiology. Since approved idiopathic pulmonary fibrosis (IPF) drugs only slow disease progression, novel therapeutics are required that improve cli…

Immune checkpoint dysregulation in COVID-19 pathogenesis and disease severity. Open

Julian A. Villalba, Julian A. Villalba, Yijia Li, Angela Shih, Sergio Poli , et al. · 2024

Accumulating evidence suggests dysregulated immune checkpoint (IC) signaling can exacerbate COVID-19 severity, but the role of these molecules in the pathogenesis of fatal COVID-19-related diffuse alveolar damage (DAD) remains elusive. Und…

Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3 Open

Chang‐Min Lee, Chuan-Hua He, Jin Wook Park, Jae‐Hyun Lee, Suchitra Kamle , et al. · 2024

Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential bioma…

Leveraging blood-based transcriptomics to detect acute cellular rejection in lung transplant Open

Auyon Ghosh, Matthew Moll, Shikshya Shrestha, Sergio Poli, Stephen J. Glatt , et al. · 2024

Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease Open

Tracy J. Doyle, Pierre‐Antoine Juge, Anna L. Peljto, Seoyeon Lee, Avram Walts , et al. · 2023

Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well as ageing and lifestyle factors such as smoking. Our objective was to determine if sh…

Plasma extracellular vesicle proteins as promising noninvasive biomarkers for diagnosis of idiopathic pulmonary fibrosis Open

Sitaramaraju Adduri, Kai Cai, Karen Velasco‐Alzate, Ravikiran Vasireddy, Jeffrey W. Miller , et al. · 2023

High‐resolution computed tomography (HRCT) imaging is critical for diagnostic evaluation of Idiopathic Pulmonary Fibrosis (IPF). However, several other interstitial lung diseases (ILDs) often exhibit radiologic pattern similar to IPF on HR…

Correction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3 Open

Chang-Min Lee, Chuan-Hua He, Jin Wook Park, Jae‐Hyun Lee, Suchitra Kamle , et al. · 2023

Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential bioma…

Serum proteomic profiling of rheumatoid arthritis–interstitial lung disease with a comparison to idiopathic pulmonary fibrosis Open

Xiaoping Wu, Yunju Jeong, Sergio Poli, Imaani Easthausen, Katherine Hoffman , et al. · 2022

Although interstitial lung disease (ILD) causes significant morbidity and mortality in rheumatoid arthritis (RA), it is difficult to predict the development or progression of ILD, emphasising the need for improved discovery through minimal…

Frailty trajectories in community‐dwelling older adults during <span>COVID</span>‐19 pandemic: The <span>PRESTIGE</span> study Open

Alberto Pilotto, Carlo Custodero, Sabrina Zora, Sergio Poli, Barbara Senesi , et al. · 2022

Background Frailty has been recognized as potential surrogate of biological age and relevant risk factor for COVID‐19 severity. Thus, it is important to explore the frailty trajectories during COVID‐19 pandemic and understand how COVID‐19 …

Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and Acute Respiratory Distress Syndrome Open

Julian A. Villalba, Caroline F. Hilburn, Michelle A. Garlin, Grant A. Elliott, Yijia Li , et al. · 2022

Rationale: The leading cause of death in coronavirus disease 2019 (COVID-19) is severe pneumonia, with many patients developing acute respiratory distress syndrome (ARDS) and diffuse alveolar damage (DAD). Whether DAD in fatal COVID…

Characterization of the COPD alveolar niche using single-cell RNA sequencing Open

Maor Sauler, John E. McDonough, Taylor Adams, Neeharika Kothapalli, Thomas Bärnthaler , et al. · 2022

Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study Open

Luis Felipe Reyes, Srinivas Murthy, Esteban García-Gallo, Mike Irvine, Laura Merson , et al. · 2021

Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. T…

Screening for preclinical parenchymal lung disease in rheumatoid arthritis Open

Anthony J. Esposito, Jeffrey A. Sparks, Ritu R. Gill, Hiroto Hatabu, Eric Schmidlin , et al. · 2021

Objectives Pulmonary disease is a common extraarticular manifestation of RA associated with increased morbidity and mortality. No current strategies exist for screening this at-risk population for parenchymal lung disease, including emphys…

The lung microbiome in end-stage Lymphangioleiomyomatosis Open

Julie Ng, Gustavo Pacheco–Rodriguez, Lesa Begley, Yvonne J. Huang, Sergio Poli , et al. · 2021

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity Open

Linh T. Bui, Nichelle I. Winters, Mei-I Chung, Chitra Joseph, Austin J. Gutierrez , et al. · 2021

Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung Open

Jonas C. Schupp, Taylor Adams, Carlos Cosme, Micha Sam Brickman Raredon, Yifan Yuan , et al. · 2021

Background: Cellular diversity of the lung endothelium has not been systematically characterized in humans. We provide a reference atlas of human lung endothelial cells (ECs) to facilitate a better understanding of the phenotypic diversity…

A novel protein signature from plasma extracellular vesicles for non-invasive differential diagnosis of idiopathic pulmonary fibrosis Open

Sitaramaraju Adduri, Kai Cai, Karen V Alzate, Ravikiran Vasireddy, Jeffrey W. Miller , et al. · 2021

Background: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia of unknown etiology often leading to respiratory failure. Over half of IPF patients present with discordant features of usual interstitial pneumonia on h…

Single Cell RNA Velocity Analysis of Aberrant Basaloid Cells in Pulmonary Fibrosis Reveals Trajectory Towards an Alveolar Type I Like Cell State Open

Jonas C. Schupp, Taylor Adams, Farida Ahangari, J.E. Mcdonough, Giuseppe DeIuliis , et al. · 2021

Analysis of Unbiased Lipidomic Data Reveals a Unique Glycerol Lipid Deregulation Signature in Idiopathic Pulmonary Fibrosis Open

M.J. Robertson, Raju V. V. Tatituri, Freddy Romero, B.J. Moss, Sergio Poli , et al. · 2021

Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPD Open

J.E. Mcdonough, Taylor Adams, Neeharika Kothapalli, Jonas C. Schupp, Jessica Nouws , et al. · 2021

Identification of IPF endotypes using publicly available gene-expression datasets Open

B.J. Moss, Tanmay Gandhi, M.J. Robertson, F. Poli, Sergio Poli , et al. · 2021

Targeting the IPF-Expanded Macrophages: Identification and Drug Discovery via scRNAseq and CyTOF Open

Sergio Poli, Ehab Ayaub, T. Adams, Jonas C. Schupp, J. Ng , et al. · 2021

CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis Open

Konstantin Tsoyi, Xiaoliang Liang, Giulia De Rossi, Stefan W. Ryter, Kevin Xiong , et al. · 2021

Rationale: CD148/PTRJ (receptor-like protein tyrosine phosphatase η) exerts antifibrotic effects in experimental pulmonary fibrosis via interactions with its ligand syndecan-2; however, the role of CD148 in human pulmonary fibrosis …

Cell-Specific Transcriptome of the COPD Alveolar Niche Open

Maor Sauler, John E. McDonough, Taylor Adams, Neeharika Kotahpalli, Jonas C. Schupp , et al. · 2021

Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death worldwide. To identify cell-specific mechanisms underlying COPD pathobiology, we analysed single-cell RNA sequencing (scRNAseq) profiles of explanted lung tissue from…

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics Open

Christoph Muus, Malte D. Luecken, Gökcen Eraslan, Lisa Sikkema, Avinash Waghray , et al. · 2021

Psychological impact of genetic and clinical screening for pulmonary fibrosis on asymptomatic first-degree relatives of affected individuals Open

Nikkola Carmichael, Jose Manuel Martinez Manzano, Luisa D. Quesada-Arias, Sergio Poli, Maura Alvarez Baumgartner , et al. · 2021

Screening for pulmonary fibrosis may help to identify early stages of the disease. We assessed the psychological impact of screening undiagnosed first-degree relatives of patients with pulmonary fibrosis by administering two validated meas…

Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis Open

EA Ayaub, Sergio Poli, Jia Lin Ng, Taylor Adams, Jonas C. Schupp , et al. · 2021

In this study, we leveraged a combination of single cell RNAseq, cytometry by time of flight (CyTOF), and flow cytometry to study the biology of a unique macrophage population in pulmonary fibrosis. Using the profiling data from 312,928 ce…

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity Open

Linh T. Bui, Nichelle I. Winters, Mei-I Chung, Chitra Joseph, Austin J. Gutierrez , et al. · 2020

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyzed the transcriptomes of 605,904 single cells isolated from healthy and CLD lungs to identify mo…

Integrated Single Cell Atlas of Endothelial Cells of the Human Lung Open

Jonas C. Schupp, Taylor Adams, Carlos Cosme, Micha Sam Brickman Raredon, Norihito Omote , et al. · 2020

Background Despite its importance in health and disease, the cellular diversity of the lung endothelium has not been systematically characterized in humans. Here we provide a reference atlas of human lung endothelial cells (ECs), to facili…

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity Open

Linh T. Bui, Nichelle I. Winters, Mei-I Chung, Chitra Joseph, Austin J. Gutierrez , et al. · 2020

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyzed the transcriptomes of 605,904 single cells isolated from healthy and CLD lungs to identify mo…

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