Santiago Gómez‐Ruiz
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Dual Synthetic Pathways for Organotin-Functionalized Mesoporous Silica Nanoparticles: Targeted Therapeutic Platforms with Folic Acid and PEI Formulation Open
Breast cancer is the most common cancer in women worldwide, with a high mortality rate. Moreover, the treatments currently used to address this disease are sometimes ineffective and cause numerous side effects. For this reason, the search …
The Spectroscopic Characterization and Photophysical Properties of a Hydrated Lanthanum Ion Complex with a Triazole Ligand by Several DFT Methods Open
The experimental IR and Raman vibrational spectra of a hydrated La(III) complex with a 1,2,3-triazole ligand were characterized by using four different Density Functional Theory (DFT) levels and two accurate scaling procedures. In the theo…
Palladium Complex‐Supported Silica Nanocarriers: Enhancing Therapeutic Efficacy and Reducing Curcumin Toxicity in Breast Cancer Open
Breast cancer (BC) is the most diagnosed tumour worldwide and triple‐negative breast carcinoma (TNBC) stands out among all subtypes due to its high aggressiveness and high mortality rate. Treatments for this subtype are limited to radio‐an…
View article: Engineered mesoporous silica nanosystems with organotin( <scp>iv</scp> ) complexes containing 1-(quinolin-8-yliminomethyl)naphthalen-2-ol ligand for cancer cell targeting
Engineered mesoporous silica nanosystems with organotin( <span>iv</span> ) complexes containing 1-(quinolin-8-yliminomethyl)naphthalen-2-ol ligand for cancer cell targeting Open
The development of targeted nanotherapeutics has emerged as a promising approach to improve the efficacy and safety of anticancer treatments based on organotin( iv ) compounds.
Enhancing photocatalytic performance of F-doped TiO<sub>2</sub> through the integration of small amounts of a quinoline-based covalent triazine framework Open
We present a hybrid material formed by F-TiO 2 and quinoline-based covalent triazine framework ( Quin-CTF ) with improved photocatalytic performance towards pollutant degradation in water.
Oxygen vacancy-engineered Bi<sub>2</sub>O<sub>2</sub>CO<sub>3</sub> nanosheets for enhanced photodegradation of pharmaceuticals and personal care products in water Open
Defect engineering has emerged as a versatile approach for tailoring the properties of materials to meet specific functional applications and improve their properties.
View article: In vitro and in silico studies of a di-copper cyclam complex for anticancer application: functionalization, cytotoxicity, ADMET profile and molecular docking as a VEGFR1 inhibitor
In vitro and in silico studies of a di-copper cyclam complex for anticancer application: functionalization, cytotoxicity, ADMET profile and molecular docking as a VEGFR1 inhibitor Open
Single crystals of the dinuclear cyclam complex (1, 4, 8, 11-tetraazacyclotetradecane)-copper (ii) tetrachlorocuprate {[Cu(14-ane)]CuCl4} (1) were prepared by soft chemistry. The powder, resulting from their grinding, was characterized by …
Albumin‐Loaded Silica Nanomaterials Functionalized with Organotin(IV) Agents: Theranostic Materials Against Triple‐Negative Breast Cancer Open
The current search for more effective and milder cancer treatments has led to the development of a wide variety of multifunctional nanoplatforms that are designed to both diagnose and treat cancer. In this study, the optimization of the sy…
Emergence of Quantum Dots as Innovative Tools for Early Diagnosis and Advanced Treatment of Breast Cancer Open
Quantum dots (QDs) semiconducting nanomaterials, have garnered attention due to their distinctive properties, including small size, high luminescence, and biocompatibility. In the context of triple‐negative breast cancer (TNBC), notorious …
Amino acid‐decorated mesoporous silica nanoparticles loaded with titanocene derivatives for targeted anticancer studies Open
Nanostructured materials possess promising potential for cancer therapy through precise adjustment of their functionalization and physicochemical attributes. This study primarily focuses on the synthesis and characterization of mesoporous …
Vanadocene-functionalized mesoporous silica nanoparticles: platforms for the development of theranostic materials against breast cancer Open
Nanoscale materials have demonstrated a very high potential in anticancer therapy by properly adjusting their functionalization and physicochemical properties. Herein, we report the synthesis of some novel vanadocene-loaded silica-based na…
Tuning adsorption capacities of hybrid mesoporous silica nanospheres and adsorption mechanism study for sulfamethoxazole and diclofenac removal from water Open
The functionalization of mesoporous silica nanospheres and mesoporous hybrid core–shell magnetic silica nanospheres has been carried out through post-synthetic procedures, and these materials have been tested as adsorbents for the removal …
Melatonin Derivative-Conjugated Formulations of Pd(II) and Pt(II) Thiazoline Complexes on Mesoporous Silica to Enhance Cytotoxicity and Apoptosis against HeLa Cells Open
The search for alternatives to cisplatin has led to the development of new metal complexes where thiazoline derivatives based on platinum(II) and palladium(II) stand out. In this sense, the Pt(II) and Pd(II) complexes coordinated with the …
Cerium-Organic Framework (CeOF) for hydrogen generation via the hydrolysis of NaBH4 Open
Hydrogen gas has been considered an eco-friendly energy source with a high energy content, making it a suitable energy carrier for several industries. A cerium-organic framework, denoted as CeOF, was synthesized by reacting cerium with a t…
Efficient visible-light-driven photocatalysis: simultaneous degradation of multiple pollutants with bismuth oxyhalide solid solutions Open
BiOCl 0.9 I 0.1 and BiOBr 0.9 I 0.1 solid solutions as promising efficient and robust photocatalysts for the concurrent and simultaneous removal of contaminants.
Unleashing the antibacterial and antibiofilm potential of silica-based nanomaterials functionalized with an organotin(<span>iv</span>) compound Open
Silica-based nanomaterials functionalized with an organotin( iv ) compound showed outstanding eradication of both E.coli and S. aureus biofilms and good antibacterial properties through ROS and RNI formation.
First-Row Transition 7-Oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies Open
Leishmaniasis and Chagas disease are still considered neglected illnesses due to the lack of investment in research, despite the fact that almost one million new cases are reported every year. Four 7-oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrim…
Organotin(IV)‐Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer Open
The pharmacological activity of organotin(IV) complexes in cancer therapy is well recognized but their large applicability is hampered by their poor water solubility. Hence, carbon dots, in particular nitrogen‐doped graphene quantum dots (…
NaBH4 Hydrolysis for Hydrogen Generation over Metal-Organic Frameworks (Cu-BTC) Open
Hydrogen gas (H2) is widely acknowledged as a sustainable and environmentally friendly energy carrier. In this study, we examined the potential of copper-based metal-organic frameworks (MOFs); copper-benzene-1,3,5-tricarboxylate (Cu-BTC), …
NaBH4 Hydrolysis for Hydrogen Generation over Metal-Organic Frameworks (Cu-BTC) Open
Hydrogen gas (H2) is widely acknowledged as a sustainable and environmentally friendly energy carrier. In this study, we examined the potential of copper-based metal-organic frameworks (MOFs); copper-benzene-1,3,5-tricarboxylate (Cu-BTC), …
Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species Open
Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, this study aimed to perform the synthesis and characterization of seven materials based on silica mesoporous nanoparticles fun…
New Carbonate-Based Materials and Study of Cytotoxic Capacity in Cancer Cells Open
Calcium carbonate, one of the most commonly found biominerals produced by organisms, has shown great potential for the development of systems with biological applications due to its excellent biocompatibility, biodegradability, and simple …
Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug Open
Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified…
Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective Open
Since the pioneering work of Vallet-Regí’s group on the design and synthesis of mesoporous silica-based materials with therapeutic applications, during the last 15 years, the potential use of mesoporous silica nanostructured materials as d…