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View article: The Role of [68Ga]Ga FAPi PET/CT in Staging and Restaging in Breast Cancer with Low FDG Uptake
The Role of [68Ga]Ga FAPi PET/CT in Staging and Restaging in Breast Cancer with Low FDG Uptake Open
Background Breast cancer is a highly heterogeneous disease, with different histopathologic subtypes exhibiting distinct biological behaviour and metabolic characteristics. While [¹⁸F]-FDG PET/CT is widely used for staging and restaging, it…
View article: Impact of 68Ga-FAPi PET/CT on Staging or Restaging Digestive System Tumors in Patients with Negative or Equivocal 18F-FDG PET/CT Findings
Impact of 68Ga-FAPi PET/CT on Staging or Restaging Digestive System Tumors in Patients with Negative or Equivocal 18F-FDG PET/CT Findings Open
Based on our study, 68Ga-FAPi PET/CT alters the disease stage in the majority of gastrointestinal malignancies with negative or equivocal 18F-FDG PET/CT findings. 68Ga-FAPi PET/CT appears to be effective in both staging and restaging of ga…
View article: Neoadjuvant Pembrolizumab Plus Chemotherapy in Early-Stage Triple-Negative Breast Cancer: A Nationwide Retrospective Turkish Oncology Group Study
Neoadjuvant Pembrolizumab Plus Chemotherapy in Early-Stage Triple-Negative Breast Cancer: A Nationwide Retrospective Turkish Oncology Group Study Open
Background/Objectives: Following the results of the phase 3 KEYNOTE-522 trial, the U.S. Food and Drug Administration approved pembrolizumab, a humanized IgG4 kappa monoclonal antibody, in combination with neoadjuvant chemotherapy as a new …
View article: Investigating Combination Therapy: The Role of Lutetium-177 PSMA-617 Radioligand Therapy and Androgen Receptor Pathway Inhibitors in Metastatic Castration-Resistant Prostate Cancer
Investigating Combination Therapy: The Role of Lutetium-177 PSMA-617 Radioligand Therapy and Androgen Receptor Pathway Inhibitors in Metastatic Castration-Resistant Prostate Cancer Open
Background: The combination of Lutetium-177 (Lu-177) PSMA-617 radioligand therapy (RLT) with androgen receptor pathway inhibitors (ARPIs) has shown promise in metastatic castration-resistant prostate cancer (mCRPC). However, real-world dat…
View article: Integrated diagnosis of grade 3-4 gliomas using targeted next-generation sequencing and traditional diagnostic data, and its overall implications on patient management
Integrated diagnosis of grade 3-4 gliomas using targeted next-generation sequencing and traditional diagnostic data, and its overall implications on patient management Open
Adult gliomas vary significantly in terms of their genetics, epigenetics, phenotypes as well as clinical outcomes [1]. Optimal tumor classification that leads to more precise diagnoses, and which influences therapy selection is hence criti…
View article: Revision of the Histopathological Examination Following 68Ga- DOTA-FAPI-04 PET/CT of a Breast Tumor Diagnosed as Invasive Ductal Carcinomatosis
Revision of the Histopathological Examination Following 68Ga- DOTA-FAPI-04 PET/CT of a Breast Tumor Diagnosed as Invasive Ductal Carcinomatosis Open
Neuroendocrine tumors (NETs) of the breast represent 1% of breast carcinomas. Histopathological misinterpretation of breast NET is common. We present the case of a female patient who had a breast mass diagnosed as invasive ductal carcinoma…
View article: Clinical Experience with [<sup>225</sup>Ac]Ac-PSMA Treatment in Patients with [<sup>177</sup>Lu]Lu-PSMA–Refractory Metastatic Castration-Resistant Prostate Cancer
Clinical Experience with [<sup>225</sup>Ac]Ac-PSMA Treatment in Patients with [<sup>177</sup>Lu]Lu-PSMA–Refractory Metastatic Castration-Resistant Prostate Cancer Open
For patients with advanced-stage metastatic castration-resistant prostate cancer (mCRPC) who do not respond to [177Lu]Lu-PSMA therapy, there are limited treatment options. Clinical results obtained with [225Ac]Ac-PSMA are promising. We ret…
View article: Assessment of Serum Resistin and Plasma Calprotectin Levels as Biomarkers of Inflammation in Patients with Familial Mediterranean Fever Disease
Assessment of Serum Resistin and Plasma Calprotectin Levels as Biomarkers of Inflammation in Patients with Familial Mediterranean Fever Disease Open
Resistin and calprotectin levels were significantly higher in patients than controls, and resistin was predictive for monitoring inflammatory activity in patients with FMF.
View article: Prognostic value of expression levels of miR‑148a, miR‑152 and HLA‑G in colon cancer
Prognostic value of expression levels of miR‑148a, miR‑152 and HLA‑G in colon cancer Open
Aberrant expression of human leukocyte antigen G (HLA-G), an immunosuppressive molecule, has been observed in various cancer types. The exact mechanism of HLA-G expression is unclear. HLA-G expression is associated with low expression leve…
View article: A rare case of mucosal metastases 14 years after resolution of a primary uveal melanoma
A rare case of mucosal metastases 14 years after resolution of a primary uveal melanoma Open
Uveal melanoma has a high metastasis rate. Following the initial diagnosis, up to 50% of patients are affected by late recurrence and gastrointestinal metastasis is found to be one of the least frequent. We report the case of a 47-year-old…
View article: The Association between Smartphone usage and General Health in Adult Cancer Patients: A Study of the Turkish Population during the COVID-19 Pandemic
The Association between Smartphone usage and General Health in Adult Cancer Patients: A Study of the Turkish Population during the COVID-19 Pandemic Open
Aim: The aim of this study is to determine the effect of smartphone screen time on general health status of adult patients with cancer compared to healthy participants in a Turkish population amidst the COVID-19 pandemic.
Materials and Me…
View article: Benefits of Neoadjuvant Chemotherapy for Luminal Breast Cancer with Respect to Tumor Response
Benefits of Neoadjuvant Chemotherapy for Luminal Breast Cancer with Respect to Tumor Response Open
ABS TRACT Objective:The pathological complete response (PCR) rate following neoadjuvant chemotherapy (NAC) is prognostic for overall survival (OS).We evaluated the pathological responses to NAC and related factors in luminal type HER2-posi…
View article: Isolated Spleen Metastasis from Lung Adenocarcinoma: A Case Report
Isolated Spleen Metastasis from Lung Adenocarcinoma: A Case Report Open
Solitary splenic metastasis is extremely rare with few reported cases in literature. Current study reports the case of a 74-year-old, female patient who was diagnosed isolated spleen metastasis after lung adenocarcinoma, in the postoperati…
View article: The inflammatory cytokine interleukin-23 is elevated in lung cancer, particularly small cell type
The inflammatory cytokine interleukin-23 is elevated in lung cancer, particularly small cell type Open
Serum IL-23 levels are elevated in lung cancer patients, particularly those with SCLC. IL-17 and IL-23 values are correlated with inflammatory markers in the patients.