Seth A. Ament
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View article: Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury
Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury Open
CNS has an overall higher level of lipids than all tissues except adipose and contains up to 25% of total body cholesterol. Recent data demonstrate a complex crosstalk between lipid metabolism and inflammation, suggesting potential contrib…
View article: Alzheimer’s Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease Onset
Alzheimer’s Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease Onset Open
View article: Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury
Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury Open
CNS has an overall higher level of lipids than all tissues except adipose and contains up to 25% of total body cholesterol. Recent data demonstrate a complex crosstalk between lipid metabolism and inflammation, suggesting potential contrib…
View article: Single-nucleus RNA sequencing reveals the cellular diversity of human cerebrospinal fluid in the context of intraventricular hemorrhage
Single-nucleus RNA sequencing reveals the cellular diversity of human cerebrospinal fluid in the context of intraventricular hemorrhage Open
Intraventricular hemorrhage (IVH) is a frequent and severe complication of hemorrhagic brain diseases. Treatment options for IVH are limited in their ability to improve long-term functional status. One promising target for treatment is the…
View article: Nucleus accumbens neuron subtype translatome signatures in socially stressed females
Nucleus accumbens neuron subtype translatome signatures in socially stressed females Open
Background The nucleus accumbens (NAc) is a reward circuitry hub associated with major depressive disorder (MDD) and chronic stress in rodents. While transcriptional adaptations in NAc medium spiny neuron (MSN) subtypes, those enriched in …
View article: The transcriptome of playfulness is sex biased in the juvenile rat medial amygdala: A role for inhibitory neurons
The transcriptome of playfulness is sex biased in the juvenile rat medial amygdala: A role for inhibitory neurons Open
Social play is a well-conserved, dynamic behavior known to be sexually differentiated. In most species, males play more than females, a sex difference largely driven by the medial amygdala (MeA), yet the full mechanism establishing this bi…
View article: Altered huntingtin−chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease
Altered huntingtin−chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease Open
While progressive striatal gene expression changes and epigenetic alterations are a prominent feature of Huntington's disease (HD), the mechanistic basis remains poorly understood. Using chromatin immunoprecipitation and sequencing (ChIP-s…
View article: A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies Open
View article: Accelerating Heritability, Genetic Correlation, and Genome‐Wide Association Imaging Genetic Analyses in Complex Pedigrees
Accelerating Heritability, Genetic Correlation, and Genome‐Wide Association Imaging Genetic Analyses in Complex Pedigrees Open
National and international biobanking efforts led to the collection of large and inclusive imaging genetics datasets that enable examination of the contribution of genetic and environmental factors to human brains in illness and health. Hi…
View article: The transcriptome of playfulness is sex-biased in the juvenile rat medial amygdala: a role for inhibitory neurons
The transcriptome of playfulness is sex-biased in the juvenile rat medial amygdala: a role for inhibitory neurons Open
Social play is a dynamic behavior known to be sexually differentiated; in most species, males play more than females, a sex difference driven in large part by the medial amygdala (MeA). Despite the well-conserved nature of this sex differe…
View article: The single-cell opioid responses in the context of HIV (SCORCH) consortium
The single-cell opioid responses in the context of HIV (SCORCH) consortium Open
View article: Transcriptional signatures of fentanyl use in the mouse ventral tegmental area
Transcriptional signatures of fentanyl use in the mouse ventral tegmental area Open
Synthetic opioids such as fentanyl contribute to the vast majority of opioid‐related overdose deaths, but fentanyl use remains broadly understudied. Like other substances with misuse potential, opioids cause lasting molecular adaptations t…
View article: Multimodal interrogation of ventral pallidum projections reveals projection-specific signatures and effects on cocaine reward
Multimodal interrogation of ventral pallidum projections reveals projection-specific signatures and effects on cocaine reward Open
The ventral pallidum (VP) is a central hub in the reward circuitry with diverse projections that have different behavioral roles attributed mostly to the connectivity with the downstream target. However, different VP projections may repres…
View article: A Curated Compendium of Transcriptomic Data for the Exploration of Neocortical Development
A Curated Compendium of Transcriptomic Data for the Exploration of Neocortical Development Open
Vast quantities of multi-omic data have been produced to characterize the development and diversity of cell types in the cerebral cortex of humans and other mammals. To more fully harness the collective discovery potential of these data, w…
View article: The Transcriptome of Playfulness is Sex-Biased in the Juvenile Rat Medial Amygdala: A Role for Inhibitory Neurons
The Transcriptome of Playfulness is Sex-Biased in the Juvenile Rat Medial Amygdala: A Role for Inhibitory Neurons Open
View article: Transcriptional signatures of fentanyl use in the mouse ventral tegmental area
Transcriptional signatures of fentanyl use in the mouse ventral tegmental area Open
Synthetic opioids such as fentanyl contribute to the vast majority of opioid-related overdose deaths, but fentanyl use remains broadly understudied. Like other substances with misuse potential, opioids cause lasting molecular adaptations t…
View article: Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus
Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus Open
The development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. To address this, we integrated transcriptomic data from 241,096 cells (126,840 newly generated) in the prenatal and adult h…
View article: Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells
Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells Open
We explore the changes in chromatin accessibility and transcriptional programs for cochlear hair cell differentiation from postmitotic supporting cells using organoids from postnatal cochlea. The organoids contain cells with transcriptiona…
View article: Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits
Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits Open
Chronic pain is at epidemic proportions in the United States, represents a significant burden on our public health system, and is coincident with a growing opioid crisis. While numerous genome-wide association studies have been reported fo…
View article: Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma
Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma Open
US NIH/NHLBI grants: P01HL132825, K99HL159234. N01-HC-25195 and HHSN268201500001I.
View article: Author Correction: Clonal haematopoiesis and risk of chronic liver disease
Author Correction: Clonal haematopoiesis and risk of chronic liver disease Open
View article: Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice
Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice Open
View article: A guide to the BRAIN Initiative Cell Census Network data ecosystem
A guide to the BRAIN Initiative Cell Census Network data ecosystem Open
Characterizing cellular diversity at different levels of biological organization and across data modalities is a prerequisite to understanding the function of cell types in the brain. Classification of neurons is also essential to manipula…
View article: The brain's dark transcriptome: Sequencing RNA in distal compartments of neurons and glia
The brain's dark transcriptome: Sequencing RNA in distal compartments of neurons and glia Open
View article: Clonal haematopoiesis and risk of chronic liver disease
Clonal haematopoiesis and risk of chronic liver disease Open
View article: Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy
Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy Open
Background: During cardiomyocyte maturation, the centrosome, which functions as a microtubule organizing center in cardiomyocytes, undergoes dramatic structural reorganization where its components reorganize from being localized at the cen…
View article: Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function
Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function Open
Higher mtDNA CN in blood is associated with better current and future general cognitive function in large and diverse communities across the United States. Although MR analyses did not support a causal role, additional research is needed t…
View article: Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population
Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population Open
View article: Depression, stress and regional cerebral blood flow
Depression, stress and regional cerebral blood flow Open
Decreased cerebral blood flow (CBF) may be an important mechanism associated with depression. In this study we aimed to determine if the association of CBF and depression is dependent on current level of depression or the tendency to exper…
View article: Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies Open