Seth R. Bauer
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View article: SIRT2 Regulates Ex Vivo PBMC Adhesion in Septic Shock Patients
SIRT2 Regulates Ex Vivo PBMC Adhesion in Septic Shock Patients Open
Background: Septic shock (SS) is deadly. Sepsis-immune response transitions from an endotoxin-sensitive, hyper-inflammatory phase to an endotoxin-tolerant hypo-inflammatory phase. In mice, we implicated sirtuin 2 (SIRT2) for prolonged hypo…
View article: Rx-LLM: a benchmarking suite to evaluate safe LLM performance for medication-related tasks
Rx-LLM: a benchmarking suite to evaluate safe LLM performance for medication-related tasks Open
Background: For large language models (LLMs) to make medication use safer, clinically relevant benchmarks capable of automated grading and measuring the performance of LLMs for medication tasks are required. The purpose of this study was t…
View article: Large language models management of medications: three performance analyses
Large language models management of medications: three performance analyses Open
Purpose: Large language models (LLMs) have proven performance for certain diagnostic tasks, however limited studies have evaluated their consistency in recommending appropriate medication regimens for a given diagnosis. Medication manageme…
View article: ADJUNCTIVE VASOPRESSORS AND SHORT-TERM MORTALITY IN ADULTS WITH SEPTIC SHOCK: A SYSTEMATIC REVIEW AND META-ANALYSIS
ADJUNCTIVE VASOPRESSORS AND SHORT-TERM MORTALITY IN ADULTS WITH SEPTIC SHOCK: A SYSTEMATIC REVIEW AND META-ANALYSIS Open
Background: Adjunctive vasopressors are added to norepinephrine in one-third of adults with septic shock in the United States. However, effectiveness of this approach is unclear, and treatment recommendations are based on indirect evidence…
View article: Forecasting disease trajectories in critical illness: comparison of probabilistic dynamic systems to static models to predict patient status in the intensive care unit
Forecasting disease trajectories in critical illness: comparison of probabilistic dynamic systems to static models to predict patient status in the intensive care unit Open
Objective Conventional prediction models fail to integrate the constantly evolving nature of critical illness. Alternative modelling approaches to study dynamic changes in critical illness progression are needed. We compare static risk pre…
View article: Baricitinib versus tocilizumab in critically ill <scp>COVID</scp>‐19 patients: A retrospective cohort study
Baricitinib versus tocilizumab in critically ill <span>COVID</span>‐19 patients: A retrospective cohort study Open
Objectives The immunomodulators tocilizumab and baricitinib improve outcomes in severely ill patients with coronavirus disease 2019 (COVID‐19); however, comparative analyses of clinical outcomes related to these agents are lacking. A tocil…
View article: Adjunctive Vasopressors in Patients with Septic Shock: Protocol for a Systematic Review and Meta-Analysis
Adjunctive Vasopressors in Patients with Septic Shock: Protocol for a Systematic Review and Meta-Analysis Open
Background Over one-third of patients with septic shock have adjunctive vasopressors added to first-line vasopressors. However, no randomized trial has detected improved mortality with adjunctive vasopressors. Published systematic reviews …
View article: Physical and Chemical Compatibility of Medications Commonly Used in Critically Ill Patients With Balanced Crystalloids: A Systematic Review
Physical and Chemical Compatibility of Medications Commonly Used in Critically Ill Patients With Balanced Crystalloids: A Systematic Review Open
Objective: Evaluate available evidence of physical and/or chemical compatibility of commonly used medications in critically ill patients with balanced crystalloids. Data sources: Ovid MEDLINE, Embase, Cochrane Central Register of Controlle…
View article: Precision fluid and vasoactive drug therapy for critically ill patients
Precision fluid and vasoactive drug therapy for critically ill patients Open
There are several clinical practice guidelines concerning the use of fluid and vasoactive drug therapies in critically ill adult patients, but the recommendations in these guidelines are often based on low‐quality evidence. Further, some w…
View article: Vasopressin Response and Clinical Trajectory in Septic Shock Patients
Vasopressin Response and Clinical Trajectory in Septic Shock Patients Open
Background In septic shock, vasopressors aim to improve tissue perfusion and prevent persistent organ dysfunction, a characteristic of chronic critical illness (CCI). Adjunctive vasopressin is often used to decrease catecholamine dosage, b…
View article: Association of Arterial pH With Hemodynamic Response to Vasopressin in Patients With Septic Shock: An Observational Cohort Study
Association of Arterial pH With Hemodynamic Response to Vasopressin in Patients With Septic Shock: An Observational Cohort Study Open
OBJECTIVES: Vasopressin is reported to retain vasoconstrictive activity in the setting of acidemia, but preclinical models are inconsistent and studies have not evaluated the clinical effectiveness of vasopressin based on arterial pH. This…
View article: Ethanol Exposure Attenuates Immune Response in Sepsis via Sirtuin 2 Expression
Ethanol Exposure Attenuates Immune Response in Sepsis via Sirtuin 2 Expression Open
Background Sepsis and septic shock kill over 270,000 patients per year in the United States. Sepsis transitions from a hyper‐inflammatory to a hypo‐inflammatory phase. Alcohol dependence is a risk factor for mortality from sepsis. Ethanol …
View article: Hemodynamic Response to Vasopressin Dosage of 0.03 Units/Min vs. 0.04 Units/Min in Patients With Septic Shock
Hemodynamic Response to Vasopressin Dosage of 0.03 Units/Min vs. 0.04 Units/Min in Patients With Septic Shock Open
Background: Arginine vasopressin (AVP) is suggested as an adjunct to norepinephrine in patients with septic shock. Guidelines recommend an AVP dosage up to 0.03 units/min, but 0.04 units/min is commonly used in practice based on initial st…
View article: What is the role of supplementation with ascorbic acid, zinc, vitamin D, or <i>N</i>-acetylcysteine for prevention or treatment of COVID-19?
What is the role of supplementation with ascorbic acid, zinc, vitamin D, or <i>N</i>-acetylcysteine for prevention or treatment of COVID-19? Open
Several agents intended to supplement dietary intake or endogenous molecules may have a theoretical role in preventing or treating COVID-19. Because of their potential to influence immune response, ascorbic acid (vitamin C), zinc, vitamin …
View article: Vasopressin Plasma Concentrations Are Not Associated with Hemodynamic Response to Exogenous Vasopressin for Septic Shock
Vasopressin Plasma Concentrations Are Not Associated with Hemodynamic Response to Exogenous Vasopressin for Septic Shock Open
Introduction Positive hemodynamic response to vasopressin after 6 hours of infusion was independently associated with lower mortality in a previous retrospective study of patients with septic shock. However, factors previously associated w…
View article: Does Measuring Serum Concentration of Procalcitonin in Critically Ill Patients Assist in Stopping Antibiotic Therapy?
Does Measuring Serum Concentration of Procalcitonin in Critically Ill Patients Assist in Stopping Antibiotic Therapy? Open
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View article: Corticosteroids for Septic Shock: Another Chapter in the Saga
Corticosteroids for Septic Shock: Another Chapter in the Saga Open
The use of corticosteroids in the management of septic shock has been a highly debated topic for quite some time. Corticosteroids have the ability to combat hyperinflammatory and exaggerated vasodilatory responses, as well as to sensitize …
View article: Perceptions regarding vasopressin use and practices in septic shock, and cost containment strategies
Perceptions regarding vasopressin use and practices in septic shock, and cost containment strategies Open
Background Clinician preferences and practices regarding appropriate vasopressin use in light of its increased acquisition cost secondary to rebranding has not been evaluated or described since the most recent iteration of the Surviving Se…
View article: Evaluation of Albumin 25% Use in Critically Ill Patients at a Tertiary Care Medical Center
Evaluation of Albumin 25% Use in Critically Ill Patients at a Tertiary Care Medical Center Open
Background: Albumin 25% has been studied and has demonstrated benefit in a limited number of patient populations. The use of albumin 25% is associated with higher costs compared with crystalloid therapy. The aim of this study was to descri…
View article: AKD—The Time Between AKI and CKD: What Is the Role of the Pharmacist?
AKD—The Time Between AKI and CKD: What Is the Role of the Pharmacist? Open
The role of pharmacists in caring for patients with AKD (1) begins with inpatient care at the time of AKI diagnosis, (2) involves patient-pharmacist interaction at hospital discharge, and (3) provides active follow-up care after hospital d…
View article: Evaluation of Antimicrobial Stewardship–Related Alerts Using a Clinical Decision Support System
Evaluation of Antimicrobial Stewardship–Related Alerts Using a Clinical Decision Support System Open
Background: Information technology, including clinical decision support systems (CDSS), have an increasingly important and growing role in identifying opportunities for antimicrobial stewardship–related interventions. Objective: The aim of…