Seth R. Bordenstein
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View article: Safeguarding microbial biodiversity: microbial conservation specialist group within the species survival commission of the International Union for Conservation of Nature
Safeguarding microbial biodiversity: microbial conservation specialist group within the species survival commission of the International Union for Conservation of Nature Open
View article: Histone acetylation modulation by a small molecule inhibitor recapitulates symbiont-induced cytoplasmic incompatibility
Histone acetylation modulation by a small molecule inhibitor recapitulates symbiont-induced cytoplasmic incompatibility Open
Symbiotic relationships between arthropod hosts and microorganisms have garnered global attention for their influence on host ecology, evolution, and vector control. A major gap in the field is to mechanistically define and reconstitute sy…
View article: Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates
Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates Open
Fungi in the gut microbiome, collectively known as the mycobiome, are a prevalent yet neglected component of the human holobiont. A major question in the study of gut microbial communities is whether fungi exhibit eco-evolutionary patterns…
View article: Evolutionary Diversification and Functions of the Candidate Male Killing Gene <i>wmk</i>
Evolutionary Diversification and Functions of the Candidate Male Killing Gene <i>wmk</i> Open
Symbiont-mediated male killing (MK) is a mechanism that selectively eliminates male offspring, often by disrupting sex-specific developmental processes. In Drosophila melanogaster, the WO-mediated killing gene wmk from Wolbachia prophage W…
View article: Gut fungi are associated with human genetic variation and disease risk
Gut fungi are associated with human genetic variation and disease risk Open
Human genetic determinants of the gut mycobiome remain uninvestigated despite decades of research highlighting tripartite relationships between gut bacteria, genetic background, and disease. Here, we present the first genome-wide associati…
View article: Host and Microbe Scale Processes Shape Spatial Variation in <i>Aphaenogaster</i> (Hymenoptera: Formicidae) Genetics and Their Microbiota
Host and Microbe Scale Processes Shape Spatial Variation in <i>Aphaenogaster</i> (Hymenoptera: Formicidae) Genetics and Their Microbiota Open
Like all ecological communities, host-associated (HA) microbiota are shaped by environmental selection and dispersal limitation. However, unlike communities of free-living organisms, communities of HA microbes experience selection and disp…
View article: Ecologically expanding the One Health framework to unify the microbiome sciences
Ecologically expanding the One Health framework to unify the microbiome sciences Open
The One Health framework, traditionally focused on microbial threats, needs a bold expansion to include the full breadth of microbial diversity—from pathogenic to beneficial—within its ecological and evolutionary context. By shifting focus…
View article: <i>Wolbachia</i> and its pWCP plasmid show differential dynamics during the development of <i>Culex</i> mosquitoes
<i>Wolbachia</i> and its pWCP plasmid show differential dynamics during the development of <i>Culex</i> mosquitoes Open
Mosquitoes are major vectors of pathogens such as arboviruses and parasites, causing significant health impacts each year. Wolbachia , an intracellular bacterium widely distributed among arthropods, represents a promising vector control so…
View article: Cytoplasmic incompatibility factor proteins from <i>Wolbachia</i> prophage are costly to sperm development in <i>Drosophila melanogaster</i>
Cytoplasmic incompatibility factor proteins from <i>Wolbachia</i> prophage are costly to sperm development in <i>Drosophila melanogaster</i> Open
The symbiosis between arthropods and Wolbachia bacteria is globally widespread, largely due to selfish-drive systems that favour the fitness of symbiont-transmitting females. The most common drive, cytoplasmic incompatibility (CI), is cent…
View article: <i>Wolbachia</i> and its pWCP plasmid show differential dynamics during the development of <i>Culex</i> mosquitoes
<i>Wolbachia</i> and its pWCP plasmid show differential dynamics during the development of <i>Culex</i> mosquitoes Open
Mosquitoes are major vectors of pathogens such as arboviruses and parasites, causing significant health impacts each year. Wolbachia , an intracellular bacterium widely distributed among arthropods, represents a promising vector control so…
View article: Safeguarding microbial biodiversity: microbial conservation specialist group within the species survival commission of the International Union for Conservation of Nature
Safeguarding microbial biodiversity: microbial conservation specialist group within the species survival commission of the International Union for Conservation of Nature Open
View article: Safeguarding microbial biodiversity: microbial conservation specialist group within the species survival commission of the International Union for Conservation of Nature
Safeguarding microbial biodiversity: microbial conservation specialist group within the species survival commission of the International Union for Conservation of Nature Open
As the first and dominant life forms on the planet, microorganisms underpin all ecological and organismal systems that drive planetary functioning, ecosystem health, and human wellbeing. Microbial communities are affected by anthropogenic …
View article: The disciplinary matrix of holobiont biology
The disciplinary matrix of holobiont biology Open
Uniting life’s seen and unseen realms guides a conceptual advance in research
View article: The mechanism of cytoplasmic incompatibility is conserved in Wolbachia-infected Aedes aegypti mosquitoes deployed for arbovirus control
The mechanism of cytoplasmic incompatibility is conserved in Wolbachia-infected Aedes aegypti mosquitoes deployed for arbovirus control Open
The rising interest and success in deploying inherited microorganisms and cytoplasmic incompatibility (CI) for vector control strategies necessitate an explanation of the CI mechanism. Wolbachia -induced CI manifests in the form of embryon…
View article: Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality
Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality Open
The extent to which prophage proteins interact with eukaryotic macromolecules is largely unknown. In this work, we show that cytoplasmic incompatibility factor A (CifA) and B (CifB) proteins, encoded by prophage WO of the endosymbiont Wolb…
View article: It is time to authenticate the Microbiome Sciences with accredited educational programs and departments
It is time to authenticate the Microbiome Sciences with accredited educational programs and departments Open
The Microbiome Sciences are at a crucial maturation stage. Scientists and educators should now view the Microbiome Sciences as a flourishing and autonomous discipline, creating degree programs and departments that are conducive to cohesive…
View article: Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age
Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age Open
Human microbiome variation is linked to the incidence, prevalence, and mortality of many diseases and associates with race and ethnicity in the United States. However, the age at which microbiome variability emerges between these groups re…
View article: Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease
Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease Open
Although profibrotic cytokines, such as IL-17A and TGF-β1, have been implicated in the pathogenesis of interstitial lung disease (ILD), the interactions between gut dysbiosis, gonadotrophic hormones and molecular mediators of profibrotic c…
View article: Low Gut Microbial Diversity Augments Estrogen-driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease
Low Gut Microbial Diversity Augments Estrogen-driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease Open
Although profibrotic cytokines such as IL-17A and TGF-β1 have been implicated in interstitial lung disease (ILD) pathogenesis, interactions between gut dysbiosis, gonadotrophic hormones and molecular mediators of profibrotic cytokine expre…
View article: Gut microbiota modulates lung fibrosis severity following acute lung injury in mice
Gut microbiota modulates lung fibrosis severity following acute lung injury in mice Open
Independent studies demonstrate the significance of gut microbiota on the pathogenesis of chronic lung diseases; yet little is known regarding the role of the gut microbiota in lung fibrosis progression. Here we show, using the bleomycin m…
View article: Transgenic cytoplasmic incompatibility persists across age and temperature variation in Drosophila melanogaster
Transgenic cytoplasmic incompatibility persists across age and temperature variation in Drosophila melanogaster Open
View article: Individuality and ethnicity eclipse a short-term dietary intervention in shaping microbiomes and viromes
Individuality and ethnicity eclipse a short-term dietary intervention in shaping microbiomes and viromes Open
Many diseases linked with ethnic health disparities associate with changes in microbial communities in the United States, but the causes and persistence of ethnicity-associated microbiome variation are not understood. For instance, microbi…
View article: Microbiome-associated human genetic variants impact phenome-wide disease risk
Microbiome-associated human genetic variants impact phenome-wide disease risk Open
Human genetic variation associates with the composition of the gut microbiome, yet its influence on clinical traits remains largely unknown. We analyzed the consequences of nearly a thousand gut microbiome-associated variants (MAVs) on phe…
View article: Widespread phages of endosymbionts: Phage WO genomics and the proposed taxonomic classification of Symbioviridae
Widespread phages of endosymbionts: Phage WO genomics and the proposed taxonomic classification of Symbioviridae Open
Wolbachia are the most common obligate, intracellular bacteria in animals. They exist worldwide in arthropod and nematode hosts in which they commonly act as reproductive parasites or mutualists, respectively. Bacteriophage WO, the largest…
View article: The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility
The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility Open
Inherited microorganisms can selfishly manipulate host reproduction to drive through populations. In Drosophila melanogaster , germline expression of the native Wolbachia prophage WO proteins CifA and CifB cause cytoplasmic incompatibility…
View article: A Margulian View of Symbiosis and Speciation: the Nasonia Wasp System
A Margulian View of Symbiosis and Speciation: the Nasonia Wasp System Open
Species are fundamental units of biology that exemplify lineage diversification, while symbiosis of microbes and macrobial hosts exemplify lineage unification between the domains of life. While these conceptual differences between speciati…
View article: Nuclease proteins CifA and CifB promote spermatid DNA damage associated with symbiont-induced cytoplasmic incompatibility
Nuclease proteins CifA and CifB promote spermatid DNA damage associated with symbiont-induced cytoplasmic incompatibility Open
Summary The worldwide endosymbiosis between arthropods and Wolbachia bacteria is an archetype for reproductive parasitism. This parasitic strategy rapidly increases the proportion of symbiont-transmitting mothers, and the most common form,…
View article: The Cif proteins from <i>Wolbachia</i> prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility
The Cif proteins from <i>Wolbachia</i> prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility Open
Inherited microorganisms can selfishly manipulate host reproduction to drive through populations. In Drosophila melanogaster , germline expression of the native Wolbachia prophage WO proteins CifA and CifB cause cytoplasmic incompatibility…
View article: The most widespread phage in animals: Genomics and taxonomic classification of Phage WO
The most widespread phage in animals: Genomics and taxonomic classification of Phage WO Open
Wolbachia are the most common obligate, intracellular bacteria in animals. They exist worldwide in arthropod and nematode hosts in which they commonly act as reproductive parasites or mutualists, respectively. Bacteriophage WO, the largest…
View article: The microbiome impacts host hybridization and speciation
The microbiome impacts host hybridization and speciation Open
Microbial symbiosis and speciation profoundly shape the composition of life’s biodiversity. Despite the enormous contributions of these two fields to the foundations of modern biology, there is a vast and exciting frontier ahead for resear…