Seth M. Schneider
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View article: Herpes simplex virus 1 glycoprotein C promotes virus penetration from endosomes during entry, independent of interaction with heparan sulfate
Herpes simplex virus 1 glycoprotein C promotes virus penetration from endosomes during entry, independent of interaction with heparan sulfate Open
Herpes simplex virus 1 (HSV-1) gC is a multi-functional glycoprotein present in the viral envelope and on the surface of infected cells. Virion gC, and to a lesser extent the fusion protein gB, interacts with host heparan sulfate to mediat…
View article: Herpes Simplex Virus Glycoprotein C Regulates Low-pH Entry
Herpes Simplex Virus Glycoprotein C Regulates Low-pH Entry Open
Herpesviruses are ubiquitous pathogens that cause lifelong latent infections and that are characterized by multiple entry pathways. We propose that herpes simplex virus (HSV) gC plays a selective role in modulating HSV entry, such as entry…
View article: Herpes Simplex Virus Glycoprotein C Regulates Low pH Entry
Herpes Simplex Virus Glycoprotein C Regulates Low pH Entry Open
Herpes simplex viruses (HSVs) cause significant morbidity and mortality in humans worldwide. Herpesviruses mediate entry by a multi-component, virus-encoded machinery. Herpesviruses enter cells by endosomal low pH and pH-neutral mechanisms…
View article: Early Steps in Herpes Simplex Virus Infection Blocked by a Proteasome Inhibitor
Early Steps in Herpes Simplex Virus Infection Blocked by a Proteasome Inhibitor Open
Viruses usurp host cell functions to advance their replicative agenda. HSV relies on cellular proteasome activity for successful infection. Proteasome inhibitors, such as MG132, block HSV infection at multiple stages of the infectious cycl…
View article: Herpes Simplex Virus 1 Envelope Cholesterol Facilitates Membrane Fusion
Herpes Simplex Virus 1 Envelope Cholesterol Facilitates Membrane Fusion Open
Methyl beta-cyclodextrin (MβCD) treatment of herpes simplex virus 1 (HSV-1) reduced envelope cholesterol levels and inhibited viral entry and infectivity in several cell types, regardless of the dependence of entry on endocytosis or low pH…