Ish Sethi
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View article: Exploring the landscape of student representation in medical curriculum development across U.S. MD schools: A comparative analysis
Exploring the landscape of student representation in medical curriculum development across U.S. MD schools: A comparative analysis Open
There is no one-size-fits-all model for student representation in medical education. However, the hybrid model shows promise for its balanced approach to integrating student perspectives into curriculum development. Continuous evaluation a…
View article: Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute Toxoplasma gondii infection
Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute Toxoplasma gondii infection Open
Inflammasome activation is a robust innate immune mechanism that promotes inflammatory responses through the release of alarmins and leaderless cytokines, including IL-1α, IL-1β, and IL-18. Various stimuli, including infectious agents and …
View article: Caspase-1 in<i>Cx3cr1</i>-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute<i>T. gondii</i>infection
Caspase-1 in<i>Cx3cr1</i>-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute<i>T. gondii</i>infection Open
Inflammasome activation is a robust innate immune mechanism that promotes inflammatory responses through the release of alarmins and leaderless cytokines, including IL-1α, IL-1β, and IL-18. Various stimuli, including infectious agents and …
View article: Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain Open
The discovery of meningeal lymphatic vessels that drain the CNS has prompted new insights into how immune responses develop in the brain. In this study, we examined how T cell responses against CNS-derived antigen develop in the context of…
View article: Author response: Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain
Author response: Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The discovery of meningea…
View article: Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis
Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis Open
Toxoplasma gondii is a ubiquitous intracellular protozoan parasite that establishes a life-long chronic infection largely restricted to the central nervous system (CNS). Constant immune pressure, notably IFN-γ-STAT1 signaling, is required …
View article: Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis
Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis Open
Toxoplasma gondii is a ubiquitous intracellular protozoan parasite that establishes a life-long chronic infection largely restricted to the central nervous system (CNS). Constant immune pressure, notably IFN-γ-STAT1 signaling, is required …
View article: Meningeal lymphatic drainage promotes T cell responses against <i>Toxoplasma gondii</i> but is dispensable for parasite control in the brain
Meningeal lymphatic drainage promotes T cell responses against <i>Toxoplasma gondii</i> but is dispensable for parasite control in the brain Open
The discovery of meningeal lymphatic vessels that drain the central nervous system (CNS) has prompted new insights into how neuroinflammation develops. In this study, we examined how T cell responses against CNS-derived antigen develop in …
View article: Microglia in CNS infections: insights from Toxoplasma gondii and other pathogens
Microglia in CNS infections: insights from Toxoplasma gondii and other pathogens Open
View article: Evaluation of pathogen specific urinary peptides in tick-borne illnesses
Evaluation of pathogen specific urinary peptides in tick-borne illnesses Open
Mass spectrometry enhanced by nanotechnology can achieve previously unattainable sensitivity for characterizing urinary pathogen-derived peptides. We utilized mass spectrometry enhanced by affinity hydrogel particles (analytical sensitivit…