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View article: Targeted gene panel sequencing of liquid and tissue biopsies reveals actionable genomic alterations in Ghanaian metastatic breast cancer cases
Targeted gene panel sequencing of liquid and tissue biopsies reveals actionable genomic alterations in Ghanaian metastatic breast cancer cases Open
Liquid biopsy detected multiple additional actionable variants in Ghanaian women with breast cancer. Plasma cfDNA analysis featured fewer variations in sample preparation which is a key consideration in resource-limited settings. Liquid bi…
View article: Early in vitro evidence indicates that deacetylated sialic acids modulate multi-drug resistance in colon and lung cancers via breast cancer resistance protein
Early in vitro evidence indicates that deacetylated sialic acids modulate multi-drug resistance in colon and lung cancers via breast cancer resistance protein Open
Cancers utilize sugar residues to engage in multidrug resistance. The underlying mechanism of action involving glycans, specifically the glycan sialic acid (Sia) and its various functional group alterations, has not been explored. ATP-bind…
View article: Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian Cancer Predisposing Gene
Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian Cancer Predisposing Gene Open
FANCI was recently identified as a new candidate ovarian cancer (OC)-predisposing gene from the genetic analysis of carriers of FANCI c.1813C>T; p.L605F in OC families. Here, we aimed to investigate the molecular genetic characteristics of…
View article: Estimating the Impact of Temperature and Rainfall on Malaria Incidence in Ghana from 2012 to 2017
Estimating the Impact of Temperature and Rainfall on Malaria Incidence in Ghana from 2012 to 2017 Open
Malaria has a significant impact on the lives of many in Ghana. It is one of the key causes of mortality and morbidity, resulting in 32.5% of outpatient visits and 48.8% of under 5-year-old hospital admissions. Future climate change may im…
View article: Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines
Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines Open
The benefit of PARP inhibitor olaparib in relapsed and advanced high-grade serous ovarian carcinoma (HGSOC) is well established especially in BRCA1/2 mutation carriers. Identification of additional biomarkers can help expand the population…
View article: Custom hereditary breast cancer gene panel selectively amplifies target genes for reliable variant calling
Custom hereditary breast cancer gene panel selectively amplifies target genes for reliable variant calling Open
Background: Target enrichment coupled with next generation sequencing provide high-throughput approaches for screening several genes of interest. These approaches facilitate screening a panel of genes for mutations associated with inherite…
View article: ADRes: a computational pipeline for detecting molecular markers of Anti-malarial Drug Resistance, from Sanger sequencing data
ADRes: a computational pipeline for detecting molecular markers of Anti-malarial Drug Resistance, from Sanger sequencing data Open
Background Malaria control efforts are stifled by the emergence and dispersal of parasite strains resistant to available anti-malarials. Amino acid changes in specific positions of proteins encoded by Plasmodium falciparum genes pfcrt, dhp…