Seulgi Shin
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View article: Pinoresinol enhances oral barrier integrity and function in human buccal cell monolayers
Pinoresinol enhances oral barrier integrity and function in human buccal cell monolayers Open
The oral epithelial barrier plays a crucial role in maintaining oral health by protecting against microbial invasion and mechanical stress while regulating selective permeability. Disruption of this barrier contributes to inflammation and …
View article: Rutin Enhances Intestinal Barrier Function and Protects Against X‐Ray Radiation‐Induced Barrier Dysfunction in Human Epithelial Caco‐2 Cells
Rutin Enhances Intestinal Barrier Function and Protects Against X‐Ray Radiation‐Induced Barrier Dysfunction in Human Epithelial Caco‐2 Cells Open
The small intestinal epithelium plays a critical role in nutrient absorption but is highly sensitive to radiation‐induced injury. Despite this vulnerability, therapeutic strategies to prevent or restore radiation‐induced intestinal barrier…
View article: Alloferon and IL-22 receptor expression regulation on the pathogenesis of imiquimod-induced psoriasis
Alloferon and IL-22 receptor expression regulation on the pathogenesis of imiquimod-induced psoriasis Open
Psoriasis is an immune-mediated inflammatory skin disease. IL-22, a proinflammatory cytokine, is implicated in psoriasis pathogenesis; however, there is currently no established biological treatment targeting IL-22 or its receptor, IL-22Rα…
View article: Anti-Inflammatory Effects of Aptamin C in Pulmonary Fibrosis Induced by Bleomycin
Anti-Inflammatory Effects of Aptamin C in Pulmonary Fibrosis Induced by Bleomycin Open
Background/Objectives: Vitamin C is a well-known antioxidant with antiviral, anticancer, and anti-inflammatory properties. However, its therapeutic applications are limited by rapid oxidation due to heat and light sensitivity. Aptamin C, w…
View article: Aptamin C enhances anti-cancer activity NK cells through the activation of STAT3: a comparative study with vitamin C
Aptamin C enhances anti-cancer activity NK cells through the activation of STAT3: a comparative study with vitamin C Open
Vitamin C is a well-known antioxidant with antiviral, anticancer, and anti-inflammatory properties based on its antioxidative function. Aptamin C, a complex of vitamin C with its specific aptamer, has been reported to maintain or even enha…
View article: Alloferon regulates the growth and movement of Trichomonas vaginalis by altering hydrogenosomes
Alloferon regulates the growth and movement of Trichomonas vaginalis by altering hydrogenosomes Open
Background Trichomoniasis infected with Trichomonas vaginalis (T. vaginalis), can cause mild symptoms like itching and burning but can also lead to more serious adverse outcomes. While typically treated with metronidazole, this medication …
View article: The Role of α-Enolase on the Production of Interleukin (IL)-32 in Con A-Mediated Inflammation and Rheumatoid Arthritis (RA)
The Role of α-Enolase on the Production of Interleukin (IL)-32 in Con A-Mediated Inflammation and Rheumatoid Arthritis (RA) Open
Interleukin (IL)-32 is produced by T lymphocytes, natural killer cells, monocytes, and epithelial cells. IL-32 induces the production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-8, and IL-32 exp…
View article: Use of surface-modified porous silicon nanoparticles to deliver temozolomide with enhanced pharmacokinetic and therapeutic efficacy for intracranial glioblastoma in mice
Use of surface-modified porous silicon nanoparticles to deliver temozolomide with enhanced pharmacokinetic and therapeutic efficacy for intracranial glioblastoma in mice Open
Octadecylated pSiNPs efficiently deliver TMZ to the brain, enhancing its accumulation and anticancer effects, resulting in extended survival in glioma-bearing mice. It highlights its potential as a promising drug delivery platform for the …
View article: NeuM: A Neuron‐Selective Probe Incorporates into Live Neuronal Membranes via Enhanced Clathrin‐Mediated Endocytosis in Primary Neurons
NeuM: A Neuron‐Selective Probe Incorporates into Live Neuronal Membranes via Enhanced Clathrin‐Mediated Endocytosis in Primary Neurons Open
The development of a small‐molecule probe designed to selectively target neurons would enhance the exploration of intricate neuronal structures and functions. Among such probes, NeuO stands out as the pioneer and has gained significant tra…
View article: Circular RNA circSmoc1-2 regulates vascular disease by acting as a miR-874-3p sponge
Circular RNA circSmoc1-2 regulates vascular disease by acting as a miR-874-3p sponge Open
View article: Amisulpride as a potential disease‐modifying drug in the treatment of tauopathies
Amisulpride as a potential disease‐modifying drug in the treatment of tauopathies Open
INTRODUCTION Hyperphosphorylation and aggregation of the microtubule‐associated protein tau cause the development of tauopathies, such as Alzheimer's disease and frontotemporal dementia (FTD). We recently uncovered a causal link between co…
View article: Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice
Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice Open
Tau oligomers play critical roles in tau pathology and are responsible for neuronal cell death and transmitting the disease in the brain. Accordingly, preventing tau oligomerization has become an important therapeutic strategy to treat tau…
View article: Methylene Blue Delivery Mediated by Focused Ultrasound-Induced Blood–Brain Barrier Disruption Reduces Neural Damage and Amyloid-Beta Plaques by AQP-4 Upregulation
Methylene Blue Delivery Mediated by Focused Ultrasound-Induced Blood–Brain Barrier Disruption Reduces Neural Damage and Amyloid-Beta Plaques by AQP-4 Upregulation Open
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease worldwide, causing progressive cognitive decline, memory impairment, and neurological deficits. Methylene blue (MB), an antioxidant, has emerged as a potential drug f…
View article: Levosimendan inhibits disulfide tau oligomerization ameliorating tau pathology in TauP301L-BiFC mice
Levosimendan inhibits disulfide tau oligomerization ameliorating tau pathology in TauP301L-BiFC mice Open
Tau oligomers play critical roles in tau pathology, responsible for neuronal cell death and transmitting the disease in the brain. Accordingly, preventing tau oligomerization becomes an important therapeutic strategy to treat tauopathies i…
View article: Author Correction: The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system
Author Correction: The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system Open
View article: The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system
The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system Open
View article: Terahertz imaging with metamaterials for biological applications
Terahertz imaging with metamaterials for biological applications Open
Terahertz (THz) technology has become more widespread due to its diverse range of potential applications, particularly when combined with various functional metamaterials using cutting-edge nanotechnology techniques. In this report, we int…
View article: Levosimendan prevents tau pathology by inhibiting disulfide-linked tau oligomerization posing as a promising anti-tau therapeutics
Levosimendan prevents tau pathology by inhibiting disulfide-linked tau oligomerization posing as a promising anti-tau therapeutics Open
Tau oligomers play critical roles in tau pathology, responsible for neuronal cell death and transmitting the disease in the brain. Accordingly, preventing tau oligomerization becomes an important therapeutic strategy to treat tauopathies i…
View article: Label-free brain tissue imaging using large-area terahertz metamaterials
Label-free brain tissue imaging using large-area terahertz metamaterials Open
View article: Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy
Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy Open
Accumulation of abnormal tau aggregates in the brain is a pathological hallmark of multiple neurodegenerative disorders including Alzheimer's disease. Increasing evidence suggests that soluble tau aggregates play a key role in tau patholog…
View article: Development of an Aryloxazole Derivative as a Brain-Permeable Anti-Glioblastoma Agent
Development of an Aryloxazole Derivative as a Brain-Permeable Anti-Glioblastoma Agent Open
Glioblastoma drug development has been difficult due to the extremely low blood brain barrier (BBB) penetration of conventional anti-cancer agents. P-glycoprotein, an efflux membrane transporter, is responsible for the poor brain uptake of…
View article: Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau
Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau Open
Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer’s disease (AD). In particular, histone deacetylase (HDAC) inhibitors including M344 and SAHA have been elucidated to be new drug can…
View article: Visualization of Tau–Tubulin Interaction in a Living Cell Using Bifluorescence Complementation Technique
Visualization of Tau–Tubulin Interaction in a Living Cell Using Bifluorescence Complementation Technique Open
Tau is a neuron-specific microtubule-binding protein that stabilizes microtubules. It is generally thought that highly phosphorylated tau dissociates from microtubules and becomes insoluble aggregates, leading to neuronal degeneration. Due…
View article: Glioblastoma-secreted soluble CD44 activates tau pathology in the brain
Glioblastoma-secreted soluble CD44 activates tau pathology in the brain Open