Seung‐Hyun Kim
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View article: cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity
cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity Open
The cyclic GMP-AMP synthase-Stimulator of Interferon Genes (cGAS–STING) pathway is an important DNA-sensing mechanism that increases T cell trafficking and activation in tumors and reverses the immunosuppressive phenotype of myeloid cells.…
View article: Development of Truss-Type Deployable Mesh Reflector Antenna, Part 1: 1.5 m-Scale Mesh Antenna
Development of Truss-Type Deployable Mesh Reflector Antenna, Part 1: 1.5 m-Scale Mesh Antenna Open
This study is an initial study for the development of a large truss-type deployable mesh antenna, and it involved the development process of a 1.5 m-scale deployable mesh antenna. The geometric characteristics of the reflector were conside…
View article: Synergistic Role of Viscoelasticity and Amphiphilicity in Binder Design for High‐Performance Silicon Electrodes
Synergistic Role of Viscoelasticity and Amphiphilicity in Binder Design for High‐Performance Silicon Electrodes Open
Silicon is a promising anode material for lithium‐ion batteries because of its high theoretical capacity. However, their practical application is hindered by substantial volume expansion during lithiation/delithiation, which leads to mecha…
View article: Evaluation of Energy Consumption for Mineral Processing of Tungsten Ore in Mongolia: Khovd Aimag and Erdene-Soum as Case Studies
Evaluation of Energy Consumption for Mineral Processing of Tungsten Ore in Mongolia: Khovd Aimag and Erdene-Soum as Case Studies Open
The tungsten deposits in Mongolia have the potential to be exploited as an alternative source to alleviate the risk due to the monopolization in the global production of such a critical metal. However, it is challenging to develop an effic…
View article: Soil–structure interaction of apartment complexes with extended underground parking
Soil–structure interaction of apartment complexes with extended underground parking Open
Buildings on flexible ground surfaces respond differently to earthquakes than those on fixed bases due to soil-structure interaction (SSI). Traditional SSI methods assume a rigid, massless foundation with limited dimensions, typically up t…
View article: Comparison of the in vitro antibiofilm activities of otic cleansers against canine otitis externa pathogens
Comparison of the in vitro antibiofilm activities of otic cleansers against canine otitis externa pathogens Open
Background Biofilm production by canine otitis externa (COE) pathogens and resistance development to multiple antimicrobials are commonly reported problems in veterinary practice. The use of adjuvants to disrupt biofilms may be a viable ad…
View article: The Role of Pomegranate (<scp><i>Punica granatum</i></scp>) in Cancer Prevention and Treatment: Modulating Signaling Pathways From Inflammation to Metastasis
The Role of Pomegranate (<span><i>Punica granatum</i></span>) in Cancer Prevention and Treatment: Modulating Signaling Pathways From Inflammation to Metastasis Open
Punica granatum , commonly known as pomegranate, is a traditional medicinal agent owing to its antiquity. The scientific literature has shown that pomegranate extracts exhibit favorable modulation of diverse signaling pathways. These pathw…
View article: Antioxidant Potential and In Vitro Antidiabetic Activity of Paeonia japonica (Makino) Miyabe & Takeda Extract and Its Isolated Compounds
Antioxidant Potential and In Vitro Antidiabetic Activity of Paeonia japonica (Makino) Miyabe & Takeda Extract and Its Isolated Compounds Open
This study explored the potential of Paeonia japonica (Makino) Miyabe & Takeda (P. japonica) as a natural treatment for diabetes. A methanol extract of the root of P. japonica and its fractions were investigated for their antioxidant and a…
View article: IMMU-45. MYELOID-ASSOCIATED WILD-TYPE IDH1 PROMOTES IMMUNOSUPPRESSION IN GLIOBLASTOMA
IMMU-45. MYELOID-ASSOCIATED WILD-TYPE IDH1 PROMOTES IMMUNOSUPPRESSION IN GLIOBLASTOMA Open
Tumor-associated myeloid cells (TAMCs) promote immunosuppression in the GBM tumor microenvironment (TME) and resistance to immune checkpoint therapy (ICT). However, the metabolic and epigenetic mechanisms underlying TAMC activation and the…
View article: EXTH-57. EXPLORING NOVEL ROUTES FOR NON-INVASIVE DRUG ADMINISTRATION: INTRADERMAL DELIVERY FOR THE TREATMENT OF BRAIN TUMORS
EXTH-57. EXPLORING NOVEL ROUTES FOR NON-INVASIVE DRUG ADMINISTRATION: INTRADERMAL DELIVERY FOR THE TREATMENT OF BRAIN TUMORS Open
Effective non-invasive drug delivery to brain tumors remains challenging, despite extensive exploration of these methods, due to the blood-brain barrier (BBB). Intranasal drug delivery has emerged as a promising alternative approach, as it…
View article: EXTH-43. ANTI-GLIOMA ACTIVITY OF BIMODAL CGAS-AGONISTIC AND STAT3-INHIBITORY SPHERICAL NUCLEIC ACIDS
EXTH-43. ANTI-GLIOMA ACTIVITY OF BIMODAL CGAS-AGONISTIC AND STAT3-INHIBITORY SPHERICAL NUCLEIC ACIDS Open
Activation of the cGAS-STING (cyclic GMP-AMP synthase-stimulator of Interferon Genes) pathway enhances T cell activation and infiltration into tumors, reversing the immunosuppressive phenotype of myeloid cells. Targeting the STING receptor…
View article: Comparison of Plasmid Curing Efficiency across Five Lactic Acid Bacterial Species
Comparison of Plasmid Curing Efficiency across Five Lactic Acid Bacterial Species Open
With the recent stringent criteria for antibiotic susceptibility in probiotics, the presence of antibiotic resistance genes and plasmids associated with their transfer has become a limiting factor in the approval of probiotics. The need to…
View article: The Effect of Complexity of a Matrix on Variation of Platinum Group Metal Determination Using ICP OES and Correction Method: A Spent Catalyst as a Case Study
The Effect of Complexity of a Matrix on Variation of Platinum Group Metal Determination Using ICP OES and Correction Method: A Spent Catalyst as a Case Study Open
Recycling of platinum group metals (PGMs) from spent catalysts is a promising alternative to the sustainable metallurgy of critical metals, which requires an accurate and reliable analytical approach for their determination. A potential mi…
View article: A Method to Simulate an Outwardly Propagating Turbulent Premixed Flame at Constant Pressure
A Method to Simulate an Outwardly Propagating Turbulent Premixed Flame at Constant Pressure Open
An outwardly propagating premixed flame in homogeneous isotropic turbulence at constant pressure is considered one of canonical configurations to study turbulent premixed flames. In this paper, a surface forcing method to prevent the undes…
View article: Separation of Lipoproteins for Quantitative Analysis of 14C-Labeled Lipid-Soluble Compounds by Accelerator Mass Spectrometry
Separation of Lipoproteins for Quantitative Analysis of 14C-Labeled Lipid-Soluble Compounds by Accelerator Mass Spectrometry Open
To date, 14C tracer studies using accelerator mass spectrometry (AMS) have not yet resolved lipid-soluble analytes into individual lipoprotein density subclasses. The objective of this work was to develop a reliable method for lipoprotein …
View article: Novel modified probiotic gold nanoparticles loaded with ginsenoside CK exerts an anti-inflammation effect via NF-κB/MAPK signaling pathways
Novel modified probiotic gold nanoparticles loaded with ginsenoside CK exerts an anti-inflammation effect via NF-κB/MAPK signaling pathways Open
Background: Gold nanoparticles (AuNPs) exhibit promising potential as medical materials due to their high biocompatibility, tunable size and shape, and excellent drug delivery capabilities, among other unique physicochemical properties. Pr…
View article: Investigation of Corrosion Behavior of Oxygen-Free Copper Canisters in Groundwater Chemistry of Deep Geological Repositories
Investigation of Corrosion Behavior of Oxygen-Free Copper Canisters in Groundwater Chemistry of Deep Geological Repositories Open
The disposal of nuclear waste represents a paramount concern for human safety, and the corrosion resistance of containers within the disposal environment stands as a critical factor in ensuring the integrity of such waste containment syste…
View article: Bending Strength Evaluation of Three Dimensional Double Rachel Geosynthetic Cementitious Composite Mat (GCCM) under Environmental Conditions
Bending Strength Evaluation of Three Dimensional Double Rachel Geosynthetic Cementitious Composite Mat (GCCM) under Environmental Conditions Open
In this study, a reinforced geosynthetic cementitious composite mat (GCCM) with improved structural stability and reinforcement efficiency through yarn-in-lay technology was designed and manufactured. Additionally, a blowing agent was adde…
View article: Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein
Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein Open
Summary Successful genome editing in primary human islets could reveal features of the genetic regulatory landscape underlying β cell function and diabetes risk. Here, we describe a CRISPR-based strategy to interrogate functions of predict…