Songhee Jeon
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View article: Gut Microbiota-Mediated Modulation of Neurodevelopmental Behavior in CLCN4- Deficient Mice
Gut Microbiota-Mediated Modulation of Neurodevelopmental Behavior in CLCN4- Deficient Mice Open
Neurodevelopmental disorders (NDDs) are associated with gut–brain axis dysfunction, and chloride ion channel 4 (CLCN4) has been implicated in their pathology. We investigated whether CLCN4 knockout (KO) alters gut microbiota and contribute…
View article: The effects of different intensities of aerobic exercise for 8 weeks on neurogenesis, depression, and anxiety in young mice
The effects of different intensities of aerobic exercise for 8 weeks on neurogenesis, depression, and anxiety in young mice Open
Purpose: This study aimed to assess the impact of aerobic exercise at different intensities over an eight-week period on the expression and activation of cortical synaptic proteins, with the potential to reduce anxiety and improve memory i…
View article: Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD
Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD Open
View article: Memory Decline and Aberration of Synaptic Proteins in X-Linked Moesin Knockout Male Mice
Memory Decline and Aberration of Synaptic Proteins in X-Linked Moesin Knockout Male Mice Open
Objective This study aims to investigate may moesin deficiency resulted in neurodevelopmental abnormalities caused by negative impact on synaptic signaling ultimately leading to synaptic structure and plasticity.Methods Behavioral assessme…
View article: Peripheral Rho-associated protein kinase activation mediates acupuncture analgesia
Peripheral Rho-associated protein kinase activation mediates acupuncture analgesia Open
View article: Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model : Endophenotypic target for ASD
Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model : Endophenotypic target for ASD Open
Chloride voltage-gated channel-4 (Clcn4) deletion is associated with autism spectrum disorder (ASD) in humans. Previous studies reported that Clcn4 knockout (KO) mice do not exhibit neurological alterations in the brain. In the present stu…
View article: PB1309 Switching from Factor VIIa to Emicizumab in Patients with Hemophilia A and Inhibitor (HAI) in Korea
PB1309 Switching from Factor VIIa to Emicizumab in Patients with Hemophilia A and Inhibitor (HAI) in Korea Open
View article: Atomoxetine and Fluoxetine Activate AMPK-ACC-CPT1 Pathway in Human SH-SY5Y and U-87 MG Cells
Atomoxetine and Fluoxetine Activate AMPK-ACC-CPT1 Pathway in Human SH-SY5Y and U-87 MG Cells Open
Objective Atomoxetine and fluoxetine are psychopharmacologic agents associated with loss of appetite and weight. Adenosine monophosphate-activated protein kinase (AMPK) is the cellular energy sensor that regulate metabolism and energy, bei…
View article: Cognitive decline and synaptopathy in X-linked moesin knock-out mice
Cognitive decline and synaptopathy in X-linked moesin knock-out mice Open
Moesin-like gene 1 antisense was increased in the postmortem cortex of patients with autism spectrum disorders. Overexpression of moesin-like gene 1 antisense induces downregulation of moesin expression in cortical neurons, resulting in de…
View article: Association between working hours and depressive symptoms among Korean employees
Association between working hours and depressive symptoms among Korean employees Open
View article: <i>Acer mono</i> Extract Inhibits Invasive Activities and G1/S Transition of HT1080 Fibrosarcoma Cells
<i>Acer mono</i> Extract Inhibits Invasive Activities and G1/S Transition of HT1080 Fibrosarcoma Cells Open
Acer mono is known to contain bioactive substances that exhibit beneficial effects in osteoporosis, gastric ulcers, hepatic damage, and pathologic angiogenesis. The current study aimed to investigate the effects of Acer mono …
View article: Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents
Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents Open
Major depressive disorder is a complex neuropsychiatric disorder with few treatment options. Non-targeted antidepressants have low efficacy and can induce series of side effects. While a neuropeptide, melanin-concentrating hormone (MCH), i…
View article: From Peripheral to Central: The Role of ERK Signaling Pathway in Acupuncture Analgesia
From Peripheral to Central: The Role of ERK Signaling Pathway in Acupuncture Analgesia Open
Despite accumulating evidence of the clinical effectiveness of acupuncture, its mechanism remains largely unclear. We assume that molecular signaling around the acupuncture needled area is essential for initiating the effect of acupuncture…
View article: Administration of a herbal formulation enhanced blastocyst implantation via IκB activation in mouse endometrium
Administration of a herbal formulation enhanced blastocyst implantation via IκB activation in mouse endometrium Open
View article: Acupuncture alleviates chronic pain and comorbid conditions in a mouse model of neuropathic pain: the involvement of DNA methylation in the prefrontal cortex
Acupuncture alleviates chronic pain and comorbid conditions in a mouse model of neuropathic pain: the involvement of DNA methylation in the prefrontal cortex Open
Chronic pain reduces life quality and is an important clinical problem associated with emotional and cognitive dysfunction. Epigenetic regulation of DNA methylation is involved in the induction of abnormal behaviors and pathological gene e…
View article: Acupuncture alleviates chronic pain and comorbidity in neuropathic pain mice: the involvement of DNA methylation in the prefrontal cortex
Acupuncture alleviates chronic pain and comorbidity in neuropathic pain mice: the involvement of DNA methylation in the prefrontal cortex Open
View article: Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson’s Disease
Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson’s Disease Open
Parkinson’s disease is the second most common neurodegenerative disease. Patients with Parkinson’s disease can be treated with a combination of acupuncture and herbal medicine, but studies on the synergistic effects of the combined treatme…
View article: Chloride channel-4 knockout mice show delayed neuronal differentiation and neurodevelopment
Chloride channel-4 knockout mice show delayed neuronal differentiation and neurodevelopment Open
View article: Biological roles of CLCN4 in human neuronal development
Biological roles of CLCN4 in human neuronal development Open
View article: Intranasal administration of melanin-concentrating hormone modulates stress response by mTOR signaling pathway
Intranasal administration of melanin-concentrating hormone modulates stress response by mTOR signaling pathway Open
View article: A Modified Formulation of Sutaehwan Ameliorates Menopausal Anxiety, Depression and Heart Hypertrophy in the VCD-Induced Menopausal Mouse Model
A Modified Formulation of Sutaehwan Ameliorates Menopausal Anxiety, Depression and Heart Hypertrophy in the VCD-Induced Menopausal Mouse Model Open
Sutaehwan (STH) has been used in Korean medicine for the treatment of abortus habitualis such as fetal restlessness in the uterus. Previously, we reported that a modified formulation of STH, Sutaehwan-Gami, has phytoestrogen-like propertie…
View article: Gami–Chunggan Formula Prevents Motor Dysfunction in MPTP/p-Induced and A53T α-Synuclein Overexpressed Parkinson’s Disease Mouse Model Though DJ-1 and BDNF Expression
Gami–Chunggan Formula Prevents Motor Dysfunction in MPTP/p-Induced and A53T α-Synuclein Overexpressed Parkinson’s Disease Mouse Model Though DJ-1 and BDNF Expression Open
The Gami-Chunggan formula (GCF) is a modification of the Chunggan (CG) decoction, which has been used to treat movement disorders such as Parkinson's disease (PD) in Traditional East Asian Medicine. To evaluate the neuroprotective effects …
View article: Restoration of Cdk5, TrkB and Soluble N-ethylmaleimide-Sensitive Factor Attachment Protein Receptor Proteins after Chronic Methylphenidate Treatment in Spontaneous Hypertensive Rats, a Model for Attention-Deficit Hyperactivity Disorder
Restoration of Cdk5, TrkB and Soluble N-ethylmaleimide-Sensitive Factor Attachment Protein Receptor Proteins after Chronic Methylphenidate Treatment in Spontaneous Hypertensive Rats, a Model for Attention-Deficit Hyperactivity Disorder Open
The results show that Cdk5, TrkB, STX1A, and SNAP25 were involved in the modulation of MPH effects in prefrontal cortex of SHRs and play important role in treatment of ADHD.
View article: Decursin induces apoptosis in glioblastoma cells, but not in glial cells <i>via</i> a mitochondria-related caspase pathway
Decursin induces apoptosis in glioblastoma cells, but not in glial cells <i>via</i> a mitochondria-related caspase pathway Open
Decursin is a major biological active component of Angelica gigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. Recently, other reports have been commissioned to examine the anticancer activities of th…
View article: Tirucallane Triterpenoids from the Stems and Stem Bark of Cornus walteri that Control Adipocyte and Osteoblast Differentiations
Tirucallane Triterpenoids from the Stems and Stem Bark of Cornus walteri that Control Adipocyte and Osteoblast Differentiations Open
Cornus walteri Wanger (Cornaceae) has been broadly used in traditional East Asian medicine for the treatment of various disorders, including skin inflammation and diarrhea. As part of our efforts to identify structurally and/or biologicall…
View article: Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice
Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice Open
The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons in the lateral hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, indicating the involvements of man…
View article: <i>Nardostachys jatamansi</i> Ethanol Extract Ameliorates Aβ42 Cytotoxicity
<i>Nardostachys jatamansi</i> Ethanol Extract Ameliorates Aβ42 Cytotoxicity Open
The Nardostachys jatamansi DC (NJ) root has been used as a sedative or analgesic to treat neurological symptoms and pain in traditional Korean medicine. Here, we investigate the potential effects of NJ on Alzheimer's disease (AD) and revea…
View article: Neuroprotective Effects of Gagam‐Sipjeondaebo‐Tang, a Novel Herbal Formula, against MPTP‐Induced Parkinsonian Mice and MPP<sup>+</sup>‐Induced Cell Death in SH‐SY5Y Cells
Neuroprotective Effects of Gagam‐Sipjeondaebo‐Tang, a Novel Herbal Formula, against MPTP‐Induced Parkinsonian Mice and MPP<sup>+</sup>‐Induced Cell Death in SH‐SY5Y Cells Open
Parkinson’s disease is a neurodegenerative disease characterized by progressive cell death of dopaminergic neuron and following neurological disorders. Gagam‐Sipjeondaebo‐Tang (GST) is a novel herbal formula made of twelve medicinal herbs …
View article: Effects of a combination treatment of KD5040 and L-dopa in a mouse model of Parkinson’s disease
Effects of a combination treatment of KD5040 and L-dopa in a mouse model of Parkinson’s disease Open
KD5040 lowered the effective dose of l -dopa and alleviated LID. These findings suggest that KD5040 may be used as an adjunct therapy to enhance the efficacy of l -dopa and alleviate its adverse effects in patients wi…
View article: Modified SJH alleviates FFAs-induced hepatic steatosis through leptin signaling pathways
Modified SJH alleviates FFAs-induced hepatic steatosis through leptin signaling pathways Open
Samjunghwan (SJH) is an herbal formula used in traditional Korean medicine. This prescription has long been used in treatment of aging and lifestyle diseases. The current study showed the effect and mechanisms of anti-hepatic steatosis act…