Séverine Lamon
YOU?
Author Swipe
View article: SUN-145 Effects of Progestogen Supplementation in Feminizing Hormone Therapy: A Mouse Model of Adolescent Gender Transition
SUN-145 Effects of Progestogen Supplementation in Feminizing Hormone Therapy: A Mouse Model of Adolescent Gender Transition Open
Disclosure: S. Calvo Blanco: None. O. Nobus: None. T. Liekens: None. L. Verlinden: None. I. Stockmans: None. K. Moermans: None. F. Stappers: None. L. Crombez: None. C. Vercruysse: None. K. Van Belleghem: None. S. Lamon: None. E. Gracey: No…
View article: <i>ACTN3</i> genotype influences androgen response in developing murine skeletal muscle
<i>ACTN3</i> genotype influences androgen response in developing murine skeletal muscle Open
Androgens act through androgen receptor (AR) to maintain muscle mass. Evidence suggests that this pathway is influenced by “the gene for speed,” ACTN3 (α-actinin-3). Given that one in five people lack α-actinin-3, it is possible that they …
View article: DNA Methylation Ageing Atlas Across 17 Human Tissues
DNA Methylation Ageing Atlas Across 17 Human Tissues Open
Aging involves widespread epigenetic remodeling across tissues, yet the nature and consistency of these changes remain unclear. We conducted a meta-analysis of more than 15,000 human methylomes spanning 17 tissues, identifying both conserv…
View article: DNA Methylation Ageing Atlas Across 17 Human Tissues
DNA Methylation Ageing Atlas Across 17 Human Tissues Open
Aging involves widespread epigenetic remodeling across tissues, yet the nature and consistency of these changes remain unclear. We conducted a meta-analysis of more than 15,000 human methylomes spanning 17 tissues, identifying both conserv…
View article: Profiling Muscle Mass, Function, and Molecular Signalling in Females Aged 18-80 and Their Associations with Sex Hormones
Profiling Muscle Mass, Function, and Molecular Signalling in Females Aged 18-80 and Their Associations with Sex Hormones Open
Whether and how ovarian hormone fluctuations mediate the skeletal muscle response to ageing in females remains to be elucidated. We examined a tightly controlled, cross-sectional cohort of 96 females between 18-80 years of age to map the f…
View article: Skeletal Muscle Mitochondria Contain Nuclear‐Encoded <scp>RNA</scp> Species Prior to and Following Adaptation to Exercise Training in Rats
Skeletal Muscle Mitochondria Contain Nuclear‐Encoded <span>RNA</span> Species Prior to and Following Adaptation to Exercise Training in Rats Open
Skeletal muscle mitochondria adaptation to exercise training is mediated by molecular factors that are not fully understood. Mitochondria import over 1000 proteins encoded by the nuclear genome, but the RNA population resident within the o…
View article: Associations Between Female Sex Hormones and Skeletal Muscle Ageing: The Baltimore Longitudinal Study of Aging
Associations Between Female Sex Hormones and Skeletal Muscle Ageing: The Baltimore Longitudinal Study of Aging Open
Background To date, most research investigating the influence of circulating sex hormones on ageing female skeletal muscle has been cross‐sectional and focused only on dichotomised young and old, or pre‐ versus post‐menopausal groups. This…
View article: The Role and Regulation of Intramuscular Sex Hormones in Skeletal Muscle: A Systematic Review
The Role and Regulation of Intramuscular Sex Hormones in Skeletal Muscle: A Systematic Review Open
Introduction Serum concentrations of androgens and estrogens, the main male and female sex hormones, respectively, naturally fluctuate across the lifespan. Sex hormones are mainly produced in the gonads, but evidence suggests that they can…
View article: The power—and complexity—of policy to drive advances in women’s health
The power—and complexity—of policy to drive advances in women’s health Open
As international investments in women’s health increase, funders are adopting sex and gender policies and regulators are requiring disaggregated data, actions which impact research design.
View article: Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations
Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations Open
Revising public health policy based on new data does not happen automatically. This is acutely relevant to the now undeniable evidence that many diseases develop differently between the sexes and may also be affected by gender. Current hea…
View article: Skeletal muscle mitochondria contain nuclear-encoded RNA species prior to and following adaptation to exercise training in rats
Skeletal muscle mitochondria contain nuclear-encoded RNA species prior to and following adaptation to exercise training in rats Open
Skeletal muscle mitochondria adaptation to exercise training is mediated by molecular factors that are not fully understood. Mitochondria import over 1000 proteins encoded by the nuclear genome, but the RNA population resident within the o…
View article: The transcriptomic signature of age and sex is not conserved in human primary myocytes
The transcriptomic signature of age and sex is not conserved in human primary myocytes Open
Background Human primary muscle cell (HPMC) lines derived from skeletal muscle biopsies are potentially powerful tools to interrogate the molecular pathways underlying fundamental muscle mechanisms. HPMCs retain their genome in culture, bu…
View article: The Role and Regulation of Intramuscular Sex Hormones in Skeletal Muscle: A Systematic Review
The Role and Regulation of Intramuscular Sex Hormones in Skeletal Muscle: A Systematic Review Open
Introduction: Serum concentrations of androgens and oestrogens, the main male and female sex hormones, respectively, naturally fluctuate across the lifespan. Sex hormones are mainly produced in the gonads, but evidence suggests that they c…
View article: The effect of age and sex hormones on female neuromuscular function across the adult lifespan
The effect of age and sex hormones on female neuromuscular function across the adult lifespan Open
Neuromuscular ageing is characterized by neural and/or skeletal muscle degeneration that decreases maximal force and power. Female neuromuscular ageing occurs earlier in life compared to males, potentially due to sex hormone changes during…
View article: Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localization of nuclear‐encoded noncoding <scp>RNAs</scp>
Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localization of nuclear‐encoded noncoding <span>RNAs</span> Open
Mitochondria are central to cellular function, particularly in metabolically active tissues such as skeletal muscle. Nuclear‐encoded RNAs typically localize within the nucleus and cytosol but a small population may also translocate to subc…
View article: Mitochondria isolated from male skeletal muscle contain a distinct population of miRNA that are differentially expressed following acute exercise
Mitochondria isolated from male skeletal muscle contain a distinct population of miRNA that are differentially expressed following acute exercise Open
Initially thought to localise at the cytosol and nucleus only, emerging evidence indicates that miRNAs also localise within the mitochondria where they could regulate diverse pathological and physiological processes. Therefore, the aim of …
View article: Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females
Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females Open
Testosterone, the major androgen, influences the reproductive and non‐reproductive systems in males and females via binding to the androgen receptor (AR). Both circulating endogenous testosterone and muscle AR protein content are positivel…
View article: Associations Between Female Sex Hormones and Skeletal Muscle Ageing: The Baltimore Longitudinal Study of Aging
Associations Between Female Sex Hormones and Skeletal Muscle Ageing: The Baltimore Longitudinal Study of Aging Open
Background To date, most research investigating the influence of circulating sex hormones on ageing female skeletal muscle has been cross-sectional and focused only on dichotomised young and old, or pre-versus post-menopausal groups. This …
View article: Direction-aware functional class scoring enrichment analysis of infinium DNA methylation data
Direction-aware functional class scoring enrichment analysis of infinium DNA methylation data Open
Infinium Methylation BeadChip arrays remain one of the most popular platforms for epigenome-wide association studies, but tools for downstream pathway analysis have their limitations. Functional class scoring (FCS) is a group of pathway en…
View article: Transitional experiences of Australian health science researchers: where is academic teaching preparedness?
Transitional experiences of Australian health science researchers: where is academic teaching preparedness? Open
Academic career development relies on a combination of teaching and research skills. In Australia, it is common for recent Doctor of Philosophy graduates to have a short-term post-doctoral research experience to build publication track-rec…
View article: Performance and Image Enhancing Drug Use Among Australian Women: The Role of Interpersonal Relationships in Facilitating Use
Performance and Image Enhancing Drug Use Among Australian Women: The Role of Interpersonal Relationships in Facilitating Use Open
Background: Women comprise a minority of performance and image-enhancing drug (PIED) consumers, with use linked to undesirable side effects. Preliminary work suggests that many women have little knowledge of what substances they are using,…
View article: Total testosterone is not associated with muscle mass, function or exercise adaptations in pre-menopausal females
Total testosterone is not associated with muscle mass, function or exercise adaptations in pre-menopausal females Open
Testosterone, the major androgen hormone, influences the reproductive and non-reproductive systems in males and females via binding to the androgen receptor (AR). Both circulating endogenous testosterone and muscle AR protein content are p…
View article: Human primary myotubes and immortalised C2C12 Cells display inconsistent metabolic gene expression and alternative polyadenylation during differentiation.
Human primary myotubes and immortalised C2C12 Cells display inconsistent metabolic gene expression and alternative polyadenylation during differentiation. Open
Data supplementing the manuscript submitted to AJP - Cell.
View article: Human primary myotubes and immortalised C2C12 Cells display inconsistent metabolic gene expression and alternative polyadenylation during differentiation.
Human primary myotubes and immortalised C2C12 Cells display inconsistent metabolic gene expression and alternative polyadenylation during differentiation. Open
Data supplementing the manuscript submitted to AJP - Cell.
View article: Human primary myotubes and immortalised C2C12 Cells display inconsistent metabolic gene expression and alternative polyadenylation during differentiation.
Human primary myotubes and immortalised C2C12 Cells display inconsistent metabolic gene expression and alternative polyadenylation during differentiation. Open
Data supplementing the manuscript submitted to AJP - Cell.
View article: Direction-aware functional class scoring enrichment analysis of Infinium DNA methylation data
Direction-aware functional class scoring enrichment analysis of Infinium DNA methylation data Open
Infinium Methylation BeadChip arrays remain one of the most popular platforms for epigenome-wide association studies, but tools for downstream pathway analysis have their limitations. Functional class scoring (FCS) is a group of pathway en…
View article: The interactive effect of sustained sleep restriction and resistance exercise on skeletal muscle transcriptomics in young females
The interactive effect of sustained sleep restriction and resistance exercise on skeletal muscle transcriptomics in young females Open
Introduction Both sleep loss and exercise regulate gene expression in skeletal muscle, yet little is known about how the interaction of these stressors affects the transcriptome. The aim of this study was to investigate the effect of nine …