Séverine Leclerc
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View article: Preterm Birth Conditions Alter Muscle Stem Cells and Their Niche, Causing Lasting Impairments in Muscle Regeneration and Function
Preterm Birth Conditions Alter Muscle Stem Cells and Their Niche, Causing Lasting Impairments in Muscle Regeneration and Function Open
Background Preterm birth‐related conditions affect the development of multiple organs, such as the heart, the lungs and the brain, leading to long‐term alterations in their function and a higher risk of comorbidities. Emerging evidence als…
View article: Therapeutic Inducers of Natural Killer cell Killing (ThINKK): preclinical assessment of safety and efficacy in allogeneic hematopoietic stem cell transplant settings
Therapeutic Inducers of Natural Killer cell Killing (ThINKK): preclinical assessment of safety and efficacy in allogeneic hematopoietic stem cell transplant settings Open
Background Allogeneic hematopoietic stem cell transplantation (HSCT) remains the standard of care for chemotherapy-refractory leukemia patients, but cure rates are still dismal. To prevent leukemia relapse following HSCT, we aim to improve…
View article: Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution
Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution Open
Heart maturation and remodelling during the foetal and early postnatal period are critical for proper survival and growth of the foetus, yet our knowledge of the molecular processes involved are lacking for many cardiac cell types. To gain…
View article: Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy
Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy Open
Healthy blood vessels supply neurons to preserve metabolic function. In blinding proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological revascularization of the ischemic neuroretina. …
View article: Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue
Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue Open
Macrophages populate the embryo early in gestation, but their role in development is not well defined. In particular, specification and function of macrophages in intestinal development remain little explored. To study this event in the hu…
View article: Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy
Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy Open
Healthy blood vessels supply neurons to preserve metabolic function. In blinding ischemic proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological neuroretina revascularization. We show…
View article: Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories
Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories Open
While persistence of fear memories is essential for survival, a failure to inhibit fear in response to harmless stimuli is a feature of anxiety disorders. Extinction training only temporarily suppresses fear memory recovery in adults, but …
View article: Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue
Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue Open
Summary Macrophages populate the embryo early in gestation but their role in the developmental process remains largely unknown. In particular, specification and function of macrophages in intestinal development remain unexplored. To study …
View article: Enhancing adult neuroplasticity by epigenetic regulation of Parvalbumin-expressing GABAergic cells
Enhancing adult neuroplasticity by epigenetic regulation of Parvalbumin-expressing GABAergic cells Open
Failure of inhibiting fear in response to harmless stimuli contributes to anxiety disorders. Extinction training only temporarily suppresses fear memories in adults, but it is highly effective in juveniles. GABAergic parvalbumin-positive (…
View article: Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1
Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1 Open
Muscle weakness and atrophy are clinical hallmarks of myotonic dystrophy type 1 (DM1). Muscle stem cells, which contribute to skeletal muscle growth and repair, are also affected in this disease. However, the molecular mechanisms leading t…
View article: AB040. Single-cell transcriptomics identifies cell-specific signatures of pathological angiogenesis
AB040. Single-cell transcriptomics identifies cell-specific signatures of pathological angiogenesis Open
Background: To treat vascular proliferative diseases, anti-VEGF therapies have shown systemic adverse effects attributable to the lack of selectivity between pathological and physiological angiogenesis. Thus, identifying the molecular mech…
View article: Dataset of Sgo1 expression in cardiac, gastrointestinal, hepatic and neuronal tissue in mouse
Dataset of Sgo1 expression in cardiac, gastrointestinal, hepatic and neuronal tissue in mouse Open
The data shown in this article are related to the research article entitled "Characterization of Sgo1 expression pattern in developing and adult mouse" (Song et al., 2017) [3]. The article provides novel data on Sgo1 gene expression patter…
View article: Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart Disease
Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart Disease Open
Left-ventricular outflow tract obstructions (LVOTO) encompass a wide spectrum of phenotypically heterogeneous heart malformations which frequently cluster in families. We performed family based whole-exome and targeted re-sequencing on 182…