Séverine Lugan
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View article: Zoonotic Potential of Chronic Wasting Disease After Adaptation in Intermediate Species
Zoonotic Potential of Chronic Wasting Disease After Adaptation in Intermediate Species Open
Chronic wasting disease (CWD) is an emerging disease in Europe. We report an increase in interspecies transmission capacity and zoonotic potential of a moose CWD isolate from Europe after passage in an ovine prion protein-expressing host. …
View article: Zoonotic potential of moose-derived chronic wasting disease prions after adaptation in intermediate species
Zoonotic potential of moose-derived chronic wasting disease prions after adaptation in intermediate species Open
International audience
View article: Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP <sup>C</sup> and Other Host-Specific Factors
Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP <sup>C</sup> and Other Host-Specific Factors Open
Prion propagation can be interfered with by the expression of a second prion protein in the host. In the present study, we investigated prion propagation in a host expressing two different prion protein genes.
View article: Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line
Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line Open
Transmission of prion infectivity to susceptible murine cell lines has simplified prion titration assays and has greatly reduced the need for animal experimentation. However, murine cell models suffer from technical and biological constrai…
View article: Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures
Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures Open
sCJD occurrence is currently assumed to result from spontaneous and stochastic formation of a misfolded PrP nucleus in the brains of affected patients. This original nucleus then recruits and converts nascent PrP C into PrP Sc , leading to…
View article: Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice
Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice Open
Classical bovine spongiform encephalopathy (BSE) is the only zoonotic prion disease described to date. Although the zoonotic potential of atypical BSE prions have been partially studied, an extensive analysis is still needed. We conducted …
View article: Prion infection, transmission and cytopathology modelled in a low-biohazard human cell line
Prion infection, transmission and cytopathology modelled in a low-biohazard human cell line Open
Transmission of prion infectivity to susceptible murine cell lines has simplified prion titration assays and has greatly reduced the need for animal experimentation. However, murine cell models suffer from technical and biological constrai…
View article: The emergence of classical BSE from atypical/Nor98 scrapie
The emergence of classical BSE from atypical/Nor98 scrapie Open
Significance The origin of transmissible BSE in cattle remains unestablished. Sheep scrapie is a potential source of this known zoonotic. Here we investigated the capacity of sheep scrapie to propagate in bovine PrP transgenic mice. Unexpe…
View article: Detection of PrPres in peripheral tissue in pigs with clinical disease induced by intracerebral challenge with sheep-passaged bovine spongiform encephalopathy agent
Detection of PrPres in peripheral tissue in pigs with clinical disease induced by intracerebral challenge with sheep-passaged bovine spongiform encephalopathy agent Open
Bovine spongiform encephalopathy (BSE) can be efficiently transmitted to pigs via intracerebral inoculation. A clear link has been established between the consumption of products of bovine origin contaminated with the BSE agent and the dev…
View article: Infectivity in bone marrow from sporadic CJD patients
Infectivity in bone marrow from sporadic CJD patients Open
Prion infectivity was recently identified in the blood of both sporadic and variant Creutzfeldt–Jakob disease (CJD) patients. In variant CJD (vCJD), the widespread distribution of prions in peripheral tissues of both asymptomatic and sympt…
View article: Distribution and Quantitative Estimates of Variant Creutzfeldt-Jakob Disease Prions in Tissues of Clinical and Asymptomatic Patients
Distribution and Quantitative Estimates of Variant Creutzfeldt-Jakob Disease Prions in Tissues of Clinical and Asymptomatic Patients Open
In the United-Kingdom, ≈1 of 2,000 persons could be infected with variant Creutzfeldt-Jakob disease (vCJD). Therefore, risk of transmission of vCJD by medical procedures remains a major concern for public health authorities. In this study,…
View article: Mononucleated Blood Cell Populations Display Different Abilities To Transmit Prion Disease by the Transfusion Route
Mononucleated Blood Cell Populations Display Different Abilities To Transmit Prion Disease by the Transfusion Route Open
Previous experiments carried out in a sheep scrapie model demonstrated that the transfusion of 200 μl of prion-infected whole blood has an apparent 100% efficacy for disease transmission. These experiments also indicated that, despite the …