Wei Sha
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View article: Key resistance-associated mutations in multidrug-resistant tuberculosis: a genomic study from Shanghai, China, with a focus on aminoglycosides
Key resistance-associated mutations in multidrug-resistant tuberculosis: a genomic study from Shanghai, China, with a focus on aminoglycosides Open
The aminoglycosides are essential drugs in the treatment of multidrug-resistant tuberculosis. Antibiotic resistance of Mycobacterium tuberculosis is a major public health concern worldwide. Therefore, it is of great significance to charact…
View article: Comparative analysis of lymphocyte subsets in tuberculosis, NTM infections, and other respiratory diseases
Comparative analysis of lymphocyte subsets in tuberculosis, NTM infections, and other respiratory diseases Open
This study revealed the lymphocyte subset characteristics of patients with TB and NTM infections and identified potential associations between disease severity, diabetes comorbidities, and immune cell subsets with disease status. These fin…
View article: Immune profiles of immune checkpoint molecules on peripheral T cells in multidrug resistant-tuberculosis
Immune profiles of immune checkpoint molecules on peripheral T cells in multidrug resistant-tuberculosis Open
Our results thus indicate that T cells exhibit more exhausted status in MDR-TB patients which could be reversed after the treatment. These results thus provide an alternative way to ameliorate MDR-TB treatment through improving anti-TB T c…
View article: Bedaquiline combined with clofazimine as salvage therapy for 11 patients with nontuberculous mycobacterial lung disease
Bedaquiline combined with clofazimine as salvage therapy for 11 patients with nontuberculous mycobacterial lung disease Open
This clinical study (ChiCTR2000037403) was registered on the Chinese Clinical Trial Registry website ( http://www.chictr.org.cn ) on August 28, 2020.
View article: In Vitro Antimicrobial Activity of Contezolid Against Mycobacterium tuberculosis and Absence of Cross-Resistance with Linezolid
In Vitro Antimicrobial Activity of Contezolid Against Mycobacterium tuberculosis and Absence of Cross-Resistance with Linezolid Open
Tuberculosis (TB) persists as a formidable global health threat, especially with the rising incidence of multidrug-resistant strains. This study aimed to evaluate the in vitro activity of contezolid, a novel oxazolidinone antibiotic, again…
View article: Genetic determinants of <i>Mycobacterium tuberculosis</i> adaptation and drug efficacy during stationary phase growth
Genetic determinants of <i>Mycobacterium tuberculosis</i> adaptation and drug efficacy during stationary phase growth Open
The adaptation of Mycobacterium tuberculosis (Mtb) to a slowly growing or nongrowing state in growth-limited conditions plays a crucial role for drug tolerance. Although the mechanisms of Mtb adaptation under growth-limited conditions have…
View article: Association of T‐Cell Profiles With Disease Severity, Drug‐Induced Liver Injury, and Treatment Completion in Tuberculosis
Association of T‐Cell Profiles With Disease Severity, Drug‐Induced Liver Injury, and Treatment Completion in Tuberculosis Open
Background Tuberculosis (TB) treatment is challenged by a long duration, poor adherence, and the high risk of drug‐induced liver injury (DILI). T‐cell immunity is essential for anti‐mycobacterial defense, but current immune‐monitoring meth…
View article: Choline and betaine concentrations in plasma predict dietary choline intake in healthy humans: a double-blind randomized control feeding study
Choline and betaine concentrations in plasma predict dietary choline intake in healthy humans: a double-blind randomized control feeding study Open
Background Choline is an essential nutrient, and insufficient intake negatively affects organs such as the liver, brain, and muscles. In the United States, average choline intake remains below the Adequate Intake (AI) (550 mg/day men, 425 …
View article: Real-world effectiveness and safety of prolonged bedaquiline course in the treatment of drug-resistant tuberculosis—a multi-center retrospective cohort study in a country with a high burden of drug-resistant tuberculosis
Real-world effectiveness and safety of prolonged bedaquiline course in the treatment of drug-resistant tuberculosis—a multi-center retrospective cohort study in a country with a high burden of drug-resistant tuberculosis Open
Bedaquiline (BDQ) has gradually become a core drug in drug-resistant tuberculosis (DR-TB) treatment, and the additional benefits of prolonging BDQ use remain unclear. Patients with DR-TB who received a BDQ-containing regimen from three Chi…
View article: Non-linear association between low-density lipoprotein cholesterol and risk of prediabetes: a retrospective cohort study based on Chinese adults
Non-linear association between low-density lipoprotein cholesterol and risk of prediabetes: a retrospective cohort study based on Chinese adults Open
Background The pathogenesis of prediabetes remains complex, particularly regarding the interactions between lipid metabolism disorders and glucose metabolism abnormalities, which warrant in-depth exploration. Low-density lipoprotein choles…
View article: Catheter-based ultrasound nerve stimulation and selective renal denervation: a preliminary case series study
Catheter-based ultrasound nerve stimulation and selective renal denervation: a preliminary case series study Open
This study aimed to evaluate the feasibility and efficacy of a catheter-based ultrasound renal denervation (RDN) system for nerve mapping guided RDN and treatment efficacy verification. A total of five patients were sequentially enrolled. …
View article: Proteogenomic characterization reveals tumorigenesis and progression of lung cancer manifested as subsolid nodules
Proteogenomic characterization reveals tumorigenesis and progression of lung cancer manifested as subsolid nodules Open
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. Nevertheless, the precise clinical management of SSNs necessitates a profound understanding of their tumorigenesis and progression. Here, we analy…
View article: Evaluating a Dual-Gene qPCR Melting Curve Assay for Rapid Detection of Tuberculosis in Suspected Pulmonary Cases
Evaluating a Dual-Gene qPCR Melting Curve Assay for Rapid Detection of Tuberculosis in Suspected Pulmonary Cases Open
The DGPMC assay is an alternative tool favorable for the detection of tuberculosis in patients with suspected pulmonary tuberculosis, especially in the patients with low bacterial load.
View article: A genome-wide association study identified PRKCB as a causal gene and therapeutic target for Mycobacterium avium complex disease
A genome-wide association study identified PRKCB as a causal gene and therapeutic target for Mycobacterium avium complex disease Open
Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic progressive lung disease that is increasing in incidence. Host genetic factors are associated with NTM-PD susceptibility. However, the heritability of NTM-PD is not well…
View article: Utilizing the renal and vertebral contours as landmarks for right adrenal vein localization in primary aldosteronism: a retrospective analysis of 310 cases
Utilizing the renal and vertebral contours as landmarks for right adrenal vein localization in primary aldosteronism: a retrospective analysis of 310 cases Open
Background Adrenal Vein Sampling (AVS) is the gold standard for categorizing primary aldosteronism (PA). However, catheterization of the right adrenal vein (RAV) can be technically challenging. This study aimed to investigate the validity …
View article: Enhanced Genome Editing Activity with Novel Chimeric ScCas9 Variants in Rice
Enhanced Genome Editing Activity with Novel Chimeric ScCas9 Variants in Rice Open
The Streptococcus canis Cas9 protein (ScCas9) recognizes the NNG protospacer adjacent motif (PAM), offering a wider range of targets than that offered by the commonly used S. pyogenes Cas9 protein (SpCas9). However, both ScCas9 and its evo…
View article: Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth
Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth Open
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for the rational design of novel intervention strategies against tuberculosis (TB). Mycobacteria possess a unique com…
View article: LncRNA SNHG16 Inhibits Intracellular <i>M. tuberculosis</i> Growth Involving Cathelicidin Pathway, Autophagy, and Effector Cytokines Production
LncRNA SNHG16 Inhibits Intracellular <i>M. tuberculosis</i> Growth Involving Cathelicidin Pathway, Autophagy, and Effector Cytokines Production Open
Long noncoding small nucleolar RNA (LncRNA) host gene 16 (SNHG16) is associated with certain diseases, including cancers. However, its role and mechanism in Mycobacterium tuberculosis (Mtb) infection remain unclear. Here, we demonstrated t…
View article: Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth
Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth Open
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for the rational design of novel intervention strategies against tuberculosis (TB). Mycobacteria possess a unique com…
View article: An additional proofreader contributes to DNA replication fidelity in mycobacteria
An additional proofreader contributes to DNA replication fidelity in mycobacteria Open
The removal of mis-incorporated nucleotides by proofreading activity ensures DNA replication fidelity. Whereas the ε-exonuclease DnaQ is a well-established proofreader in the model organism Escherichia coli , it has been shown that proofre…
View article: Single-cell transcriptomics of blood identified IFIT1 neutrophil subcluster expansion in NTM-PD patients
Single-cell transcriptomics of blood identified IFIT1 neutrophil subcluster expansion in NTM-PD patients Open
Our data revealed disease-specific immune cell subclusters and provided potential new targets of NTM-PD. Specific expansion of IFIT1+ neutrophil subclusters and the CXCL8-CXCR1/2 axis may be involved in the pathogenesis of NTM-PD. These in…
View article: How does climate change affect potential yields of four staple grain crops worldwide by 2030?
How does climate change affect potential yields of four staple grain crops worldwide by 2030? Open
Global food security basically depends on potential yields of staple grain crops worldwide, especially under climate change. However, most scholars use various models of production function in which climatic factors are often considered to…