Shaad E. Abdullah
2023
Data from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
2023 • Nabendu Pore, Song Wu, Nathan Standifer, Maria Jure‐Kunkel, Melissa de los Reyes, Yashaswi Shrestha, Rebecca Halpin, Raymond Rothstein, Kathy Mulgr...
2023
Supplementary Table S3 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
2023 • Nabendu Pore, Song Wu, Nathan Standifer, Maria Jure‐Kunkel, Melissa de los Reyes, Yashaswi Shrestha, Rebecca Halpin, Raymond Rothstein, Kathy Mulgr...
2023
Supplementary Table S8 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
2023 • Nabendu Pore, Song Wu, Nathan Standifer, Maria Jure‐Kunkel, Melissa de los Reyes, Yashaswi Shrestha, Rebecca Halpin, Raymond Rothstein, Kathy Mulgr...
2023
Supplementary Figure S7 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
2023 • Nabendu Pore, Song Wu, Nathan Standifer, Maria Jure‐Kunkel, Melissa de los Reyes, Yashaswi Shrestha, Rebecca Halpin, Raymond Rothstein, Kathy Mulgr...
2024
Tebentafusp Induces a T-Cell–Driven Rash in Melanocyte-Bearing Skin as an Adverse Event Consistent with the Mechanism of Action
2024 • Jessica C. Hassel, Sarah Stanhope, Alexander Greenshields‐Watson, Devayani Machiraju, Alexander Enk, Christopher Holland, Shaad E. Abdullah, Adel B...
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Exploring foci of
2024-07-15
Tebentafusp Induces a T-Cell–Driven Rash in Melanocyte-Bearing Skin as an Adverse Event Consistent with the Mechanism of Action
2024-07-15 • Jessica C. Hassel, Sarah Stanhope, Alexander Greenshields‐Watson, Devayani Machiraju, Alexander Enk, Christopher Holland, Shaad E. Abdullah, Adel B...
Tebentafusp is a gp100xCD3-bispecific ImmTAC designed to redirect polyclonal T cells against cells presenting the melanocyte lineage-specific antigen gp100 on HLA-A∗02:01. Skin-related adverse events, predominantly rash, are frequent and occur within a few hours after initial infusions; yet, the mechanisms are unknown. In this study, we analyzed clinical data from the randomized phase 3 trial (NCT03070392) of tebentafusp (n = 252) versus investigator's choice (n = 126). Translational analyses were performed on pai…
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T-Cell Receptor
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Exploring foci of
2023-04-03
Data from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
2023-04-03 • Nabendu Pore, Song Wu, Nathan Standifer, Maria Jure‐Kunkel, Melissa de los Reyes, Yashaswi Shrestha, Rebecca Halpin, Raymond Rothstein, Kathy Mulgr...
<div>Abstract<p>Mutations in the <i>STK11 (LKB1)</i> gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. <i>STK11</i> mutations were associated with resistance to the anti–PD-L1 antibody durvalumab (alone/with the anti-CTLA4 antibody tremelimumab) independently of <i>KRAS</i> mutational status, highlighting <i>STK11</i> a…
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Hello Muddah, Hello Fadduh (A Letter From Camp)
Resistance (Video Game Series)
Computer Data Storage
So Far From God
Resistance Thermometer
Nordic Resistance Movement
Tales From Planet Earth
Tokenization (Data Security)
Plan 9 From Outer Space
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Exploring foci of
2023-04-03
Supplementary Table S3 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
2023-04-03 • Nabendu Pore, Song Wu, Nathan Standifer, Maria Jure‐Kunkel, Melissa de los Reyes, Yashaswi Shrestha, Rebecca Halpin, Raymond Rothstein, Kathy Mulgr...
<p>Cytokines and other soluble factors evaluated in the baseline serum of patients with STK11mut or STK11wt tumors.</p>
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Hello Muddah, Hello Fadduh (A Letter From Camp)
History Of The Periodic Table
So Far From God
Tales From Planet Earth
Algonquin Round Table
Plan 9 From Outer Space
Away From Her
The Girl From Everywhere
The View From Saturday
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Exploring foci of
2023-04-03
Supplementary Table S8 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
2023-04-03 • Nabendu Pore, Song Wu, Nathan Standifer, Maria Jure‐Kunkel, Melissa de los Reyes, Yashaswi Shrestha, Rebecca Halpin, Raymond Rothstein, Kathy Mulgr...
<p>Kaplan-Meier analysis using a log rank (Mantel-Cox) test to compare survival among the treatment groups represented in Figure 5. A total of 9 comparisons between groups were conducted. P-values were not adjusted for multiple comparisons.</p>
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Hello Muddah, Hello Fadduh (A Letter From Camp)
History Of The Periodic Table
So Far From God
Tales From Planet Earth
Algonquin Round Table
Plan 9 From Outer Space
Away From Her
The Girl From Everywhere
The View From Saturday
Open Article Page
Exploring foci of
2023-04-03
Supplementary Figure S7 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
2023-04-03 • Nabendu Pore, Song Wu, Nathan Standifer, Maria Jure‐Kunkel, Melissa de los Reyes, Yashaswi Shrestha, Rebecca Halpin, Raymond Rothstein, Kathy Mulgr...
<p>Characterization of STAT3 phosphorylation in the CT26 STK11 KO model and from primary human NSCLC tumors. (A) Representative multispectral fluorescence imaging of phosphorylated murine STAT3 (pSTAT3), CD45, CD163, and nuclei (DAPI), as indicated, with quantification of positive cells per mm2 in CT26 tumors. 26C16 STK11 KI indicates CT26 STK11 KO clone 26C16 engineered to re-express WT STK11. (B) Normalized protein expression levels of human STAT3 phosphorylated at tyrosine 705 (Y705) from STK11mut and STK…
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Hello Muddah, Hello Fadduh (A Letter From Camp)
So Far From God
Tales From Planet Earth
Plan 9 From Outer Space
Javier Fernández (Figure Skater)
Away From Her
The Girl From Everywhere
The View From Saturday
Suicide Notes From Beautiful Girls
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