Shagun Krishna
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View article: Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro
Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro Open
Industrial and agricultural chemicals such as pesticides are often considered to have restricted biological activity. Yet, there are concerns regarding their broader toxicity range and impact on human gut microbiota. Here we report a syste…
View article: Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis
Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis Open
Dysregulation of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) contributes to atherosclerosis and cardiovascular disease (CVD), making it a potential target for CVD risk assessment. High-throughput screening (HTS) appr…
View article: Correction: Novel Curcumin Monocarbonyl Analogue-Dithiocarbamate hybrid molecules target human DNA ligase I and show improved activity against colon cancer
Correction: Novel Curcumin Monocarbonyl Analogue-Dithiocarbamate hybrid molecules target human DNA ligase I and show improved activity against colon cancer Open
View article: Improved hLigI inhibition activity of Curcumin Monocarbonyl Analogue-Dithiocarbamate Hybrids: Design, Synthesis and Biology
Improved hLigI inhibition activity of Curcumin Monocarbonyl Analogue-Dithiocarbamate Hybrids: Design, Synthesis and Biology Open
Human DNA ligase (hLigI) plays an important role in the process of DNA replication and repair, making it an important target for cancer. In our tireless efforts for finding selective inhibitors against hLigI, this article reports the desig…
View article: High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition
High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition Open
Chemical inhibition of the human ether-a -go-go-related gene (hERG) potassium channel leads to a prolonged QT interval that can contribute to severe cardiotoxicity. The adverse effects of hERG inhibition are one of the principal causes of …
View article: A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models
A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models Open
Existing cancer therapies are often associated with drug resistance and toxicity, which results in poor prognosis and recurrence of cancer. This necessitates the identification and development of novel therapeutics against existing as well…
View article: Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its sister Leptomonas
Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its sister Leptomonas Open
Background Leptomonas is monogenetic kinetoplastid parasite of insects and is primitive in comparison to Leishmania . Comparative studies of these two kinetoplastid may share light on the evolutionary transition to dixenous parasitism in L…
View article: Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes
Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes Open
Recent advances indicate a possible role of phytochemicals as modulatory factors in signaling pathways. We have previously demonstrated PHLPP2-mediated suppression of Nrf2 responses during oxidant attack. The present study was designed to …
View article: Additional file 1: Figure S1. of Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its sister Leptomonas
Additional file 1: Figure S1. of Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its sister Leptomonas Open
Multiple sequence alignment of FTase (α-subunit) of Leishmania donovani (accession number XP_003862625.1, putative protein) with FTase (α-subunit) of Leishmania major (accession number XP_003722277.1, putative protein), Leishmania infantum…