Shalin Shah
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View article: Evaluation of the Impact of Oral Implant with Different Thread Designs on Marginal Bone Loss: A Comparative Study
Evaluation of the Impact of Oral Implant with Different Thread Designs on Marginal Bone Loss: A Comparative Study Open
Thread design affects bone loss primarily by the way it transmits mechanical stress to the surrounding bone. In order to avoid high stress concentrations around the implant neck, which are linked to bone resorption, an optimized design is …
View article: AI-Powered Radiotherapy for Resource-Limited Settings: Advancing Cervical and Prostate Cancer Treatment Planning with the Radiation Planning Assistant (RPA)
AI-Powered Radiotherapy for Resource-Limited Settings: Advancing Cervical and Prostate Cancer Treatment Planning with the Radiation Planning Assistant (RPA) Open
1. ABSTRACT Purpose Radiotherapy treatment planning is a resource-intensive process characterized by multiple manual steps and clinical hand-offs that contribute to treatment delays and inter-observer variability. The Radiation Planning As…
View article: Safety of Contemporary Radiation Therapy in Patients With Cardiac Implantable Electronic Devices: Implications for Clinical Practice
Safety of Contemporary Radiation Therapy in Patients With Cardiac Implantable Electronic Devices: Implications for Clinical Practice Open
Background Radiation therapy (RT) can cause cardiac implantable electronic device (CIED) malfunction, primarily reset. Given changes in RT and CIED technologies, large observational studies examining malfunction of contemporary CIEDs durin…
View article: HYDROCEPHALUS IN CEREBELLOPONTINE ANGLE TUMORS: EVALUATING THE ROLE OF VENTRICULOPERITONEAL SHUNTS
HYDROCEPHALUS IN CEREBELLOPONTINE ANGLE TUMORS: EVALUATING THE ROLE OF VENTRICULOPERITONEAL SHUNTS Open
Background: Hydrocephalus is a frequent and serious complication of cerebellopontine angle (CPA) tumors due to cerebrospinal fluid (CSF) flow obstruction. Ventriculoperitoneal (VP) shunting is commonly used to relieve intracranial pressure…
View article: International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation
International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation Open
Background Pathologic extranodal extension (pENE) is a crucial prognostic factor in oropharyngeal cancer (OPC), but determining pENE from imaging has high inter‐observer variability. The role of clinician specialty in the accuracy of imagi…
View article: Feasibility of Laryngeal Joint Replacement: A Proof of Concept Study in Cadavers
Feasibility of Laryngeal Joint Replacement: A Proof of Concept Study in Cadavers Open
Objective Posterior laryngeal stenosis is a vexing problem despite efforts at early tracheostomy in those intubated on ventilatory support. Treatment in advanced cases relies on permanent tracheostomy or irreversible arytenoidectomy/cordec…
View article: Systematic Review: Effectiveness of Carbon Dioxide Lasers for Treatment of Adult Laryngeal Hemangioma
Systematic Review: Effectiveness of Carbon Dioxide Lasers for Treatment of Adult Laryngeal Hemangioma Open
Importance Adult laryngeal hemangiomas are rare and may cause symptoms such as dysphonia, dysphagia, and dyspnea. Carbon dioxide (CO2) lasers offer an alternative approach to managing this rare condition. Objective The objective of this st…
View article: Knowledge-based planning for fully automated radiation therapy treatment planning of 10 different cancer sites
Knowledge-based planning for fully automated radiation therapy treatment planning of 10 different cancer sites Open
KBP models for multiple treatment sites were used as a basis to generate fully automatable, efficient, consistent, high-quality, and clinically acceptable plans. These plans do not require human intervention, demonstrating the potential th…
View article: Bladder-preserving radiation therapy for patients with locally advanced and node-positive bladder cancer
Bladder-preserving radiation therapy for patients with locally advanced and node-positive bladder cancer Open
In this cohort with LA-MIBC treated with RT, distant failures predominate, local failures are less common, and toxicity was minimal. Survival outcomes remain encouraging for RT in this challenging patient population. Further investigation …
View article: Colours of India: Uniting Endocrinologists in Fitness and Friendship
Colours of India: Uniting Endocrinologists in Fitness and Friendship Open
Colours of India is an annual cultural phenomenon that transcends the boundaries of professional conferences, uniting endocrinologists through the universal language of music and dance. Since its inception in 2016, this vibrant event has b…
View article: Development and clinical implementation of a digital workflow utilizing 3D-printed oral stents for patients with head and neck cancer receiving radiotherapy
Development and clinical implementation of a digital workflow utilizing 3D-printed oral stents for patients with head and neck cancer receiving radiotherapy Open
3D-printed stents were successfully fabricated and well tolerated by patients. As patients enroll in the randomized phase of this trial, data herein will establish a baseline for comparative analysis.
View article: 8P Amivantamab plus chemotherapy vs chemotherapy in EGFR-mutant advanced NSCLC after progression on osimertinib: Secondary analyses of patient-relevant endpoints from MARIPOSA-2
8P Amivantamab plus chemotherapy vs chemotherapy in EGFR-mutant advanced NSCLC after progression on osimertinib: Secondary analyses of patient-relevant endpoints from MARIPOSA-2 Open
Amivantamab (ami) is an EGFR-MET bispecific antibody with immune cell-directing activity. In MARIPOSA-2 (NCT04988295), ami plus carboplatin-pemetrexed (ami-chemo) significantly prolonged progression-free survival (PFS) vs chemo (HR, 0.48; …
View article: 3MO Amivantamab plus chemotherapy vs chemotherapy in EGFR-mutant advanced NSCLC after progression on osimertinib: A post-progression analysis of MARIPOSA-2
3MO Amivantamab plus chemotherapy vs chemotherapy in EGFR-mutant advanced NSCLC after progression on osimertinib: A post-progression analysis of MARIPOSA-2 Open
Amivantamab (ami) is an EGFR-MET bispecific antibody with immune cell-directing activity. In MARIPOSA-2 (NCT04988295), ami plus carboplatin-pemetrexed (ami-chemo) significantly prolonged progression-free survival (PFS) vs chemo in patients…
View article: Optimizing Outpatient Radiation Oncology Consult Workflow by Using Time-Driven Activity-Based Costing: Efficiency and Financial Impacts
Optimizing Outpatient Radiation Oncology Consult Workflow by Using Time-Driven Activity-Based Costing: Efficiency and Financial Impacts Open
PURPOSE Clinical efficiency is a key component of value-based health care. Our objective here was to identify workflow inefficiencies by using time-driven activity-based costing (TDABC) and evaluate the implementation of a new clinical wor…
View article: A Novel Polymer-Encapsulated Multi-Imaging Modality Fiducial Marker with Positive Signal Contrast for Image-Guided Radiation Therapy
A Novel Polymer-Encapsulated Multi-Imaging Modality Fiducial Marker with Positive Signal Contrast for Image-Guided Radiation Therapy Open
Background: Current fiducial markers (FMs) in external-beam radiotherapy (EBRT) for prostate cancer (PCa) cannot be positively visualized on magnetic resonance imaging (MRI) and create dose perturbation and significant imaging artifacts on…
View article: Clinical Utility of 3D CT Pulmonary Imaging in the Quantitative Evaluation of Fibrosis, Emphysema, and Airway Tapering Indices: A Review
Clinical Utility of 3D CT Pulmonary Imaging in the Quantitative Evaluation of Fibrosis, Emphysema, and Airway Tapering Indices: A Review Open
Three-dimensional computed tomography (3D CT) pulmonary imaging has emerged as a pivotal tool in the quantitative assessment of chronic lung diseases, including pulmonary fibrosis, emphysema, and airway tapering associated with chronic obs…
View article: A phase II clinical trial of frameless, fractionated stereotactic radiation therapy for brain metastases
A phase II clinical trial of frameless, fractionated stereotactic radiation therapy for brain metastases Open
Stereotactic radiation therapy yields high rates of local control for brain metastases, but patients in rural or suburban areas face geographic and socioeconomic barriers to its access. We conducted a phase II clinical trial of frameless, …
View article: Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: primary results from the phase III MARIPOSA-2 study
Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: primary results from the phase III MARIPOSA-2 study Open
Amivantamab-chemotherapy and amivantamab-lazertinib-chemotherapy improved PFS and intracranial PFS versus chemotherapy in a population with limited options after disease progression on osimertinib. Longer follow-up is needed for the modifi…
View article: Supplemental Table 1 from Clinical Response of a Patient to Anti–PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors
Supplemental Table 1 from Clinical Response of a Patient to Anti–PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors Open
List of TCGA samples included in this study.
View article: Supplemental Table 3 from Clinical Response of a Patient to Anti–PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors
Supplemental Table 3 from Clinical Response of a Patient to Anti–PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors Open
Significant biological processes (FDR<0.05) enriched in the 1,015 genes co-clustered with known T cell gene signatures. Among 1,015 genes, 771 were associated with GO annotation in DAVID database v6.7. Count: number of genes from my list t…
View article: Supplemental Table 3 from Clinical Response of a Patient to Anti–PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors
Supplemental Table 3 from Clinical Response of a Patient to Anti–PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors Open
Significant biological processes (FDR<0.05) enriched in the 1,015 genes co-clustered with known T cell gene signatures. Among 1,015 genes, 771 were associated with GO annotation in DAVID database v6.7. Count: number of genes from my list t…
View article: Data from Clinical Response of a Patient to Anti–PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors
Data from Clinical Response of a Patient to Anti–PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors Open
Anti–Programed Death 1 (PD-1) is standard immunotherapy for multiple cancers, and the expression of one of its ligands, PD-L1, has been described in germ cell tumors (GCT). Neither the clinical activity of anti–PD-1 nor the incidence of an…