Explanipedia

Outcomes of surgical aortic valve replacement for mixed aortic valve disease Open

Jennifer L. Philip, Tiffany Zens, Lucian Lozonschi, Nilto C. De Oliveira, Satoru Osaki , et al. · 2018

Predominant AS associated with higher AI grades had larger LV dimensions and worse LV function preoperatively. These differences resolve after AVR with equivalent survival. However, predominant AI with more severe AS had reduced survival d…

Does Left Ventricular Assist Device Mechanics Impact Pre Cardiac Transplant Allosensitization and Post-Transplant Survival? Open

Salman Allana, Jinn‐Ing Liou, Elizabeth A. Jacobs, Tom Ellis, Peter S. Rahko , et al. · 2016

Clinical Outcomes and Survival after Continuous-Flow Left Ventricular Assist Device Therapy in United States Veterans: A Single Center Experience Open

Entela B. Lushaj, Lucian Lozonschi, Takushi Kohmoto, Shahab A. Akhter, Margaret Murray , et al. · 2016

Pre-Transplant Donor Specific Antibody Levels Using Single Antigen Bead Assay and Long-Term Survival Post Heart Transplant Open

Ravi Dhingra, Mingxi Yu, M.R. Johnson, Lucian Lozonschi, Takushi Kohmoto , et al. · 2016

Continuous-flow left ventricular assist devices and bleeding events: Is there a biological role for decreasing pump speed? Open

Shahab A. Akhter · 2016

Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4 Open

Tiju Theccanat, Jennifer L. Philip, Abdur Razzaque, Nicholas Ludmer, Jinju Li , et al. · 2015

G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts. Open

Karen M. D’Souza, Ricky Malhotra, Jennifer L. Philip, Michelle L. Staron, Tiju Theccanat , et al. · 2015

Cardiac fibroblasts (CF) make up 60-70% of the total cell number in the heart and play a critical role in regulating normal myocardial function and in adverse remodeling following myocardial infarction and the transition to heart failure. …

Invited Commentary Open

Shahab A. Akhter · 2015

Duration of Continuous-Flow Left Ventricular Assist Device Support Does Not Impact Heart Transplant Operative Variables and Long-Term Survival Open

Entela B. Lushaj, Takushi Kohmoto, Lucian Lozonschi, Satoru Osaki, Margaret Murray , et al. · 2015

Outcomes in Cardiac Transplant Recipients According to Pretransplant AT1R Antibody Levels and Donor AT1R Polymorphisms Open

M. Zacharias, B. Hynes, Nancy K. Sweitzer, M.R. Johnson, Shahab A. Akhter , et al. · 2015

Impact of age on outcomes following continuous-flow left ventricular assist device implantation Open

Entela B. Lushaj, Abbasali Badami, Satoru Osaki, Margaret Murray, Glen Leverson , et al. · 2015

This study demonstrates that LVAD therapy can be used in the older patients with acceptable mortality and morbidity, and age alone should not be used as the sole criterion for exclusion from LVAD implantation.

Regulation of mitochondrial oxidative stress by β-arrestins in cardiac fibroblasts Open

Jennifer L. Philip, Abdur Razzaque, Mei Han, Jinju Li, Tiju Theccanat , et al. · 2015

Oxidative stress in cardiac fibroblasts (CF) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH oxidase 4 (Nox4) is a major source of cardiac reactive o…

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