Explanipedia

Studies on the Sub-lethal Exposure of Camphor on the Hematology and Serum Biochemistry of Silver Carp Open

Nahla Ehsan, Sajid Abdullah, Shawana Ambreen, Muhammad Zeeshan, Muhammad Ismail , et al. · 2025

Camphor is frequently used as medicine to treat variety of illnesses; it also has significant harmful effects on aquatic life. Many studies revealed camphor exposure can have an impact regarding the serum biochemical and hematological vari…

Complete loss of SLC30A8 in humans improves glucose metabolism and beta cell function Open

Lindsey B. Lamarche, Christopher Koch, Shareef Khalid, Maleeha Khan, Richard Zessis , et al. · 2025

Aims/hypothesis Genetic association studies have demonstrated that partial loss of SLC30A8 Function protects against type 2 diabetes in humans. We investigated the impact of complete loss of SLC30A8 Function on type 2 diabetes risk and rel…

FAMILY DYNAMICS AND ENGLISH LANGUAGE ACQUISITION IN MULTICULTURAL HOUSEHOLDS: A CROSS-COUNTRY ETHNOGRAPHIC STUDY Open

Dr Reema Qaralleh, Syed Naeem Ahmed, Shahid Abbas, Shazia Hamid, Hafsa Hayee · 2025

Multilingual households are rapidly expanding worldwide, yet most research still focuses on monolingual or bilingual families, leaving the dynamics of multilingual households underexplored. Guided by Coleman’s Family Capital Theory, this s…

Safety of Early Discharge After Primary Angioplasty Open

Ahmad Salman, Mumtaz Akhtar, Rehan Riaz, Liaqat Ali, Shahid Abbas , et al. · 2025

Early discharge following primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction (STEMI) has gained attention due to its potential to optimize healthcare resources without compromising patient safety. Whil…

Comparative Study of Lateral Anal Sphincterotomy Versus Botulinum Toxin Injection for Treatment of Chronic Anal Fissure Open

Asim Aslam, Muhammad Jalil Malik, Madhia Sundas, Farukh Gulzar Khawaja, Abdulrasheed A. Nasir , et al. · 2025

Objective: To compare lateral internal sphincterotomy with injection Botulinum toxin for chronic anal fissure treatment in terms of improvement in mean postoperative pain, frequency of healing and fecal incontinence. Study Design: Quasi-ex…

Mapping Segmental Variations in Pakistani English: A Sociophonetic Study Open

Hafiz Ahmad Bilal, Rabia Faiz, Ijaz Asghar, Shahid Abbas · 2025

FREQUENCY OF IMPROVEMENT IN LEFT VENTRICULAR EJECTION FRACTION AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS PRESENTING WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION Open

Muhammad Amjad, Shahid Abbas · 2025

Background: ST-segment elevation myocardial infarction (STEMI) is a critical cardiac emergency that often leads to impaired ventricular function and increased mortality. Primary percutaneous coronary intervention (PCI) has emerged as the g…

Human CD33 deficiency is associated with mild alteration of circulating white blood cell counts Open

John Dominy, Jirong Bai, Christopher Koch, Maleeha Khan, Shareef Khalid , et al. · 2025

The single pass transmembrane protein CD33 is enriched in phagocytic and hematopoietic cell types, such as monocytes. CD33 is thought to be associated with immune cell function, susceptibility to Alzheimer’s disease, and rare leukemias. An…

THE ROLE OF ARTIFICIAL INTELLIGENCE IN PERSONALIZED MEDICINE AND PREDICTIVE DIAGNOSTICS – A NARRATIVE REVIEW Open

Shahid Abbas, Abdul Sattar, Syeda Hina Shah, Sidrah Hafeez, Waqas Mahmood , et al. · 2025

Background: Artificial intelligence (AI) has revolutionized personalized medicine and predictive diagnostics by enabling data-driven, individualized healthcare strategies. AI-powered models leverage vast datasets, including genomic, proteo…

Neurotrophic keratitis caused by trigeminal nerve palsy secondary to a cerebellopontine angle epidermoid cyst: A rare case presentation. Open

Shahid Abbas, T SAJJAD, S Ahmed · 2024

Neurotrophic keratitis (NK) is a rare corneal disorder characterized by decreased corneal sensitivity and impaired corneal healing due to damage or dysfunction of the trigeminal nerve. We present a case of NK caused by trigeminal nerve pal…

Serum uric acid: an independent risk factor for cardiovascular disease in Pakistani Punjabi patients Open

Misbah Hussain, Muhammad Umer Ghori, Muhammad Naeem Aslam, Shahid Abbas, Muhammad Shafique , et al. · 2024

This study showed that SUA is positively associated with CVD, thus it can act as an independent risk factor for CVD.

Serum uric acid: an independent risk factor for cardiovascular disease in Pakistani Punjabi patients Open

Misbah Hussain, Muhammad Umer Ghori, Muhammad Naeem Aslam, Shahid Abbas, Muhammad Shafique , et al. · 2024

Background: It is well known that serum uric acid (SUA) can increase the risk of hypertension, diabetes, obesity and dyslipidemia. However, its independent association with the risk of cardiovascular diseases (CVD) is controversial particu…

Complete loss of<i>SLC30A8</i>in humans improves glucose metabolism and beta cell function Open

Lindsey B. Lamarche, Christopher Koch, Shareef Khalid, Maleeha Zaman, Richard Zessis , et al. · 2024

Genetic association studies have demonstrated that partial loss of SLC30A8 function protects against type 2 diabetes (T2D) in humans, but the impact of complete loss of SLC30A8 function remains unknown. From whole-exome and genome sequenci…

Identification and characterization of human GDF15 knockouts Open

Allan Gurtan, Shareef Khalid, Christopher Koch, Maleeha Khan, Lindsey B. Lamarche , et al. · 2024

Growth differentiation factor 15 (GDF15) is a secreted protein that regulates food intake, body weight, and stress responses in pre-clinical models 1 . The physiological function of GDF15 in humans remains unclear. Pharmacologically, GDF15…

Ethanolic and Aqueous Extracts of Rosa Damascena Mill. Leaves Mitigate Diabetes, Lipid Panel Restoration and Regeneration of Β Cells in the Alloxan-Induced Diabetic Rats Open

Zunaira Zulfiqar, Sibtain Ahmed, Shahid Abbas, Muhammad Asad Ali, Shagufta Saeed , et al. · 2024

Commemorating 123 years of Allergy Immunotherapy Open

Shahid Abbas · 2023

South Asian medical cohorts reveal strong founder effects and high rates of homozygosity Open

Jeffrey D. Wall, J. Fah Sathirapongsasuti, Ravi Gupta, Asif Rasheed, Venkatesan Radha , et al. · 2023

Study factors associated with poor glycemic control in type 2 diabetes mellitus patients in tertiary care center Open

Anita Mathuriya, Shahid Abbas · 2023

Background: Poor glycemic control is a major public health issue among patients with type 2 diabetes mellitus and a significant risk factor for the progression of diabetic complications. This study aimed to assess the magnitude and contrib…

ASSESSMENT OF CARDIAC FUNCTIONS IN RELATION WITH ELECTROCARDIOGRAPHY AND ECHOCARDIOGRAPHY IN CHRONIC ALCOHOLIC PATIENTS Open

Mohit Bhargava, Shahid Abbas · 2023

Background: Alcohol is most commonly abused drug worldwide. It has been shown to produce toxic effects in almost every organ system in the body. Many of these medical conditions can be attributed to direct effects of alcohol whereas others…

ASSESSMENT OF CARDIAC FUNCTIONS IN RELATION WITH ELECTROCARDIOGRAPHY AND ECHOCARDIOGRAPHY IN CHRONIC ALCOHOLIC PATIENTS Open

Mohit Bhargava, Shahid Abbas · 2023

Background: Alcohol is most commonly abused drug worldwide. It has been shown to produce toxic effects in almost every organ system in the body. Many of these medical conditions can be attributed to direct effects of alcoh…

Injection Sclerotherapy vs Rubber Band Ligation in the Management of Patients with 2nd Degree Haemorrhoids Open

Zahid Raza, Muhammad Rusdan Jalil, Waseem Khan, Jehanzeb Rahman, Shahid Abbas , et al. · 2023

Objective: To compare the efficacy of injection sclerotherapy and rubber band ligation in patients with 2nd degree haemorrhoids. Study design & Setting: Prospective Observational study was conducted in PNS Shifa Karachi from 1st July 2018 …

Reduction in pulmonary artery pressures on right heart cath after percutaneous transmitral commissurotomy. Open

Naeem Hameed, Shahid Abbas · 2023

Objectives: To find out the reduction in pulmonary artery pressures on right heart Cath after percutaneous trans mitral commissurotomy. Study Design: Cross-sectional Observational study. Setting: Catheterization Lab Faisalabad Institute of…

From Theory to Practice: Transitivity Analysis of Alfred Tennyson’s Home They Brought Her Warrior Dead Open

Ameer Sultan, Shahid Abbas, Shahid Hussain Mir · 2023

This paper investigates the progression of the narrative and the psychological and emotional development of the major character in Home They Brought her Warrior Dead by applying Halliday’s theory of transitivity. Transitivity patterns are …

STUDY OF RADIOGRAPHIC FEATURES OF RENAL OSTEODYSTROPHY IN CHRONIC KIDNEY DISEASE (CKD) AND THEIR CORRELATION WITH CLINICAL AND BIOCHEMICAL PARAMETERS Open

Abhishek Mehta, Shahid Abbas, Utkarsh Balani · 2022

Background: Although frequently silent, mineral and bone disease (MBD) is one of the most precocious complication of chronic kidney disease (CKD) and is omnipresent in patients with CKD stage 5. In recognition of the identical, our study w…

outcome of Intracoronary Tirofiban administration at Primary Percutaneous Coronary Intervention in St-Elevation Myocardial Infarction Patients Open

Muhammad Asim Saddique, Muhammad Munawar Jamshaid, Shahid Abbas, Komal Jabeen · 2022

Background: ST-elevation myocardial infarction results from obstruction of coronary flow due to intracoronary thrombus formation. Primary PCI is the gold standard and class-I indication for revascularization following STEMI. Investigators …

Frequency of acute heart failure in patients undergoing thrombolysis for anterior wall myocardial infarction. Open

Rehan Riaz, Muhammad Ghayas, Naeem Hameed, Shahid Abbas, Asadullah · 2022

Objective: To determine frequency of acute heart failure in patient undergoing thrombolysis for anterior wall MT. Study Design: Cross-sectional study. Setting: Faisalabad Institute of Cardiology, Faisalabad. Period: July 2017 to December 2…

Frequency of Thyroid Dysfunction in Heart Failure Patients with Reduced Ejection Fraction Open

Muhammad Amir Misbah ul Qamar, Shahid Abbas, Andaleeb Khan, Ejaz Ali, Kamil Rehman Butt , et al. · 2022

Objective: To look for the frequency of thyroid dysfunction in heart failure patients with reduced ejection fraction at Medicine/Cardiology Department. Study Design: Cross-sectional study. Place and Duration of Study: Combined Military H…

Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index Open

Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari L. Caplan , et al. · 2022

Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. P…

Association between elevated red cell distribution width and in-hospital mortality in patients with acute decompensated heart failure. Open

Muhammad Asim Saddique, Asif Manzoor, Shahid Abbas, Hassan Asghar Randhawa · 2022

Objective: To determine the frequency of death ratio in hospitalized patients has acute decompensated heart failure (ADHF) with elevated red cell distribution width (RDW). Study Design: Descriptive Cross-sectional Analysis. Setting: Armed …

The diagnostic accuracy of mean arterial pressure in second trimester for prediction of preeclampsia in females. Open

Sidra Mushtaq, Naeem Hameed, Rabika Bint Khamis Butt, Shahid Abbas, Ali Sajjad · 2021

Objective: To assess the diagnostic accuracy of mean arterial pressure in second trimester for prediction of pre-eclampsia in females. Study Design: Cross-sectional study. Setting: Department of Obstetrics & Gynecology Unit III, Allied hos…

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