Shahid M. Nimjee
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View article: Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection
Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection Open
Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired interferon responses, and defective T-cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood. Caspase-11 (CA…
View article: DSA Versus Noninvasive Imaging in Revascularization Referral for Recently Symptomatic Carotid Stenosis
DSA Versus Noninvasive Imaging in Revascularization Referral for Recently Symptomatic Carotid Stenosis Open
BACKGROUND Current revascularization guidelines for symptomatic carotid artery stenosis were established based on randomized studies where stenosis was assessed with digital subtraction angiography. Pursuing revascularization in clinical p…
View article: Decision-Making for Endovascular Thrombectomy in Patients With Large Vessel Occlusions and Mild Neurological Deficit: A Consensus Statement
Decision-Making for Endovascular Thrombectomy in Patients With Large Vessel Occlusions and Mild Neurological Deficit: A Consensus Statement Open
Acute ischemic stroke patients with mild deficits (National Institutes of Health Stroke Scale [NIHSS] of 0–5) but confirmed large vessel occlusions (LVO) present a clinical challenge for endovascular thrombectomy (EVT) decisions due to lim…
View article: Literature review and DELPHI consensus on follow-up and retreatment of intracranial aneurysms with intrasaccular devices
Literature review and DELPHI consensus on follow-up and retreatment of intracranial aneurysms with intrasaccular devices Open
Background Intracranial aneurysms are increasingly detected incidentally due to broader use of neuroimaging. Intrasaccular devices are frequently used to prevent rupture, yet standardized follow-up and retreatment strategies remain undefin…
View article: Clinical outcomes and independently adjudicated results of M2 aspiration thrombectomy: a subgroup analysis from the Imperative Trial
Clinical outcomes and independently adjudicated results of M2 aspiration thrombectomy: a subgroup analysis from the Imperative Trial Open
Background The ESCAPE-MeVO (Endovascular Treatment to Improve Outcomes for Medium Vessel Occlusions) and DISTAL (Endovascular Therapy plus Best Medical Treatment vs Best Medical Treatment Alone for Medium Vessel Occlusion Stroke) trials fa…
View article: Outcomes of bypass surgery in asymptomatic moyamoya angiopathy: A multicenter study with propensity-score weighting
Outcomes of bypass surgery in asymptomatic moyamoya angiopathy: A multicenter study with propensity-score weighting Open
Introduction: Asymptomatic moyamoya angiopathy (MMA) is increasingly detected through noninvasive imaging; however, its optimal management remains controversial. This multicenter retrospective cohort study compared outcomes in asymptomatic…
View article: Semi-automated tortuosity measurements confirm generalizability of IMPERATIVE trial results to real-world patients with acute ischemic stroke undergoing thrombectomy
Semi-automated tortuosity measurements confirm generalizability of IMPERATIVE trial results to real-world patients with acute ischemic stroke undergoing thrombectomy Open
Background Criticism of clinical trials of endovascular therapy of acute ischemic stroke due to large vessel occlusion includes their lack of generalizability. We aimed to evaluate the impact of vessel tortuosity on the outcomes of large-b…
View article: Evaluating Animal Models of Arteriovenous Malformation and Intracerebral Aneurysm: A Mechanistic Approach
Evaluating Animal Models of Arteriovenous Malformation and Intracerebral Aneurysm: A Mechanistic Approach Open
Arteriovenous malformations (AVMs) and intracranial aneurysms contribute to a high degree of morbidity and mortality due to the risk of intracranial hemorrhage observed in each of these cerebrovascular disorders. Due to the morbidity prese…
View article: Rats subject to extracorporeal membrane oxygenation have improved cardiac function following anticoagulation and reversal with factor IXa aptamer-antidote oligonucleotide pair
Rats subject to extracorporeal membrane oxygenation have improved cardiac function following anticoagulation and reversal with factor IXa aptamer-antidote oligonucleotide pair Open
Background and purpose: Unfractionated heparin (UFH) is the most commonly utilized rapid-onset anticoagulant, valued for its potency and reversibility with protamine. However, UFH and protamine are associated with significant side effects,…
View article: Predictors of perioperative stroke in patients with Ischemic-type moyamoya disease treated with surgical revascularization: A retrospective multicenter study
Predictors of perioperative stroke in patients with Ischemic-type moyamoya disease treated with surgical revascularization: A retrospective multicenter study Open
Hypertension and smoking were significant predictors of perioperative stroke in patients with ischemic-type MMD undergoing surgical revascularization. These findings emphasize the importance of managing risk factors in ischemic-type MMD. F…
View article: Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial
Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial Open
View article: Abstract 011: Early multi‐center experience with the NEVA VS in the treatment of subarachnoid hemorrhage‐related cerebral vasospasm
Abstract 011: Early multi‐center experience with the NEVA VS in the treatment of subarachnoid hemorrhage‐related cerebral vasospasm Open
Introduction Cerebral vasospasm represents a formidable challenge in the aftermath of subarachnoid hemorrhage (SAH), significantly contributing to morbidity and mortality. This life‐threatening and potentially reversible complication is co…
View article: Abstract 001: Aspiration with super‐large bore 0.088 ID catheters in patients with acute ischemic stroke: The final results of an FDA‐approved trial
Abstract 001: Aspiration with super‐large bore 0.088 ID catheters in patients with acute ischemic stroke: The final results of an FDA‐approved trial Open
Introduction Aspiration thrombectomy is a well‐established treatment for patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, the safety and efficacy of aspiration using super‐large bore catheters (0.088”…
View article: Abstract 419: The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID‐19 Related Vascular Thrombosis
Abstract 419: The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID‐19 Related Vascular Thrombosis Open
Introduction Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has been associated with hypercoagulability and an increased incidence of thrombotic events as compared to other viral resp…
View article: The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis
The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis Open
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellula…
View article: Von Willebrand factor targeted thrombolysis in canine basilar artery occlusion
Von Willebrand factor targeted thrombolysis in canine basilar artery occlusion Open
Background and purpose Posterior circulation strokes, accounting for 20% of acute ischemic strokes, significantly contribute to morbidity and mortality. Fibrinolysis by rtPA improves outcomes in stroke but the risk of intracranial hemorrha…
View article: Utilizing a portable magnetic resonance imaging (MRI) in the setting of an acute ischemic stroke in a patient with a cardiac implantable electronic device
Utilizing a portable magnetic resonance imaging (MRI) in the setting of an acute ischemic stroke in a patient with a cardiac implantable electronic device Open
Background Cardiac implantable electronic device (CIED) generally excludes patients from undergoing fixed, high-field magnetic resonance imaging (MRI). Acute ischemic stroke patients undergo MRI as a standard part of an assessment of infar…
View article: The impact of hypertension on clinical outcomes in moyamoya disease: a multicenter, propensity score-matched analysis
The impact of hypertension on clinical outcomes in moyamoya disease: a multicenter, propensity score-matched analysis Open
Background Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive steno-occlusive changes in the internal carotid arteries, leading to an abnormal vascular network. Hypertension is prevalent among MMD patien…
View article: Endovascular treatment to improve outcomes for medium vessel occlusions: The ESCAPE-MeVO trial
Endovascular treatment to improve outcomes for medium vessel occlusions: The ESCAPE-MeVO trial Open
Rationale: Clinical outcomes in acute ischemic stroke due to medium vessel occlusion (MeVO) are often poor when treated with best medical management. Data from non-randomized studies suggest that endovascular treatment (EVT) may improve ou…
View article: Diffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients
Diffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients Open
Objective For stroke patients with unknown time of onset, mismatch between diffusion‐weighted imaging (DWI) and fluid‐attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) can guide thrombolytic intervention. However, acce…
View article: Review: Preclinical Models of Large‐Vessel Occlusion Stroke
Review: Preclinical Models of Large‐Vessel Occlusion Stroke Open
Preclinical models of large‐vessel occlusion (LVO) stroke play an important role in testing novel thrombolytic and neuroprotective agents, as well as assessing endovascular devices for endovascular thrombectomy. Depending on the modality u…
View article: Patients’ perceptions on outcomes after mechanical thrombectomy in acute ischemic stroke
Patients’ perceptions on outcomes after mechanical thrombectomy in acute ischemic stroke Open
Background The modified Rankin Scale (mRS) is a clinician-reported scale that measures the degree of disability in patients who suffered a stroke. Patients’ perception of a meaningful recovery from severe stroke, expected value of a stroke…
View article: A Novel Case of Transverse Sinus Stenting and Ticagrelor Use During Pregnancy for Idiopathic Intracranial Hypertension
A Novel Case of Transverse Sinus Stenting and Ticagrelor Use During Pregnancy for Idiopathic Intracranial Hypertension Open
Background Idiopathic intracranial hypertension (IIH) is prevalent among the US population, with exacerbation of symptoms during pregnancy. Transverse sinus stenting is a new effective treatment for IIH. Stenting is avoided in pregnancy la…
View article: PB1222 ROTEM-Identified Hyperfibrinolysis does not Correlate with Poor Outcomes in Large Vessel Occlusion Stroke
PB1222 ROTEM-Identified Hyperfibrinolysis does not Correlate with Poor Outcomes in Large Vessel Occlusion Stroke Open
Background: Thrombolysis therapy in patients with stroke or pulmonary embolism is associated with bleeding complications which typically occur in up to 9.9% (1,2).Identification of patient with increased risk for bleeding possibly can infl…
View article: PB1218 Aptamer Inhibitor of Von Willebrand Factor Induces Thrombolysis and Improves Vascular Patency Upon Immediate and Delayed Treatment in a Microfluidic Model of Stroke
PB1218 Aptamer Inhibitor of Von Willebrand Factor Induces Thrombolysis and Improves Vascular Patency Upon Immediate and Delayed Treatment in a Microfluidic Model of Stroke Open
Conclusion(s): While a subset of ischemic stroke patients undergoing thrombectomy that received IVT converted to a hyperfibrinolytic state, this did not impact cognitive outcomes.The conversion to hyperfibrinolysis may involve patient-spec…
View article: Intravenous Drug Use‐Associated Endocarditis Leads to Increased Intracranial Hemorrhage and Neurological Comorbidities
Intravenous Drug Use‐Associated Endocarditis Leads to Increased Intracranial Hemorrhage and Neurological Comorbidities Open
Background The United States is experiencing a rapidly increasing rate of opioid drug abuse. Intravenous drug use (IVDU)‐related endocarditis can lead to significant neurological complications with high morbidity and mortality. When patien…
View article: Factors Associated With Improved Technical Outcomes When Using 0.068‐ to 0.074‐Inch Aspiration Catheters: Analysis From a Multicenter Retrospective Cohort
Factors Associated With Improved Technical Outcomes When Using 0.068‐ to 0.074‐Inch Aspiration Catheters: Analysis From a Multicenter Retrospective Cohort Open
Background In addition to enlarging the catheter tip diameter, recent aspiration catheters were designed with a novel angled‐tip design. We aimed to evaluate the efficacy of new‐generation angled‐tip aspiration catheters in comparison to c…
View article: A canine thromboembolic model of anterior circulation large vessel occlusion stroke
A canine thromboembolic model of anterior circulation large vessel occlusion stroke Open
We demonstrate a thromboembolic canine model of MCAO that is both feasible and results in consistent infarct volumes to generate a clinically relevant LVO. This model is important to evaluate treatment of LVO in acute ischemic stroke (AIS)…
View article: Rapid molecular imaging of active thrombi in vivo using aptamer-antidote probes
Rapid molecular imaging of active thrombi in vivo using aptamer-antidote probes Open
View article: Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion
Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion Open
Von Willebrand Factor (VWF) plays a critical role in thrombus formation, stabilization, and propagation. Previous studies have demonstrated that targeted inhibition of VWF induces thrombolysis when administered in vivo in animal models of …