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View article: MAPK signaling and angiopoietin-2 contribute to endothelial permeability in capillary malformations
MAPK signaling and angiopoietin-2 contribute to endothelial permeability in capillary malformations Open
Nonsyndromic capillary malformations (CM) are seen predominantly in skin. In Sturge–Weber Syndrome (SWS), CMs occur in the skin, leptomeninges of the brain, and choroid of the eye. >90% of CM are caused by a somatic mutation— GNAQ p.R183Q,…
View article: MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations
MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations Open
Capillary malformations (CM) are slow-flow vascular abnormalities present at birth and predominantly manifest as cutaneous lesions. In the rare neurocutaneous disorder known as Sturge Weber Syndrome (SWS), individuals exhibit CM not only o…
View article: An endothelial specific mouse model for the capillary malformation mutation Gnaq p.R183Q
An endothelial specific mouse model for the capillary malformation mutation Gnaq p.R183Q Open
Capillary malformation (CM) is a congenital, non-hereditary lesion composed of enlarged and tortuous blood vessels. CM is associated with a somatic GNAQ p.R183Q activating mutation in endothelial cells (EC). Cutaneous CMs are present in 1/…
View article: An endothelial SOX18–mevalonate pathway axis enables repurposing of statins for infantile hemangioma
An endothelial SOX18–mevalonate pathway axis enables repurposing of statins for infantile hemangioma Open
Infantile hemangioma (IH) is the most common tumor in children and a paradigm for pathological vasculogenesis, angiogenesis, and regression. Propranolol, the mainstay of treatment, inhibits IH vessel formation via a β-adrenergic receptor-i…
View article: Spinal Tuberculosis (Pott’s Disease): A Case Report and Clinical Considerations
Spinal Tuberculosis (Pott’s Disease): A Case Report and Clinical Considerations Open
Pott's disease (PD), also known as spinal tuberculosis, accounts for an extremely low percentage of all tuberculosis (TB) cases and typically manifests secondary to an extra-spinal infection through the hematogenous spread. The thoracolumb…
View article: Multiple cell types including melanocytes contribute to elastogenesis in the developing murine aortic valve
Multiple cell types including melanocytes contribute to elastogenesis in the developing murine aortic valve Open
Elastic fibers are crucial for aortic valve (AoV) function and are generated and maintained by valvular interstitial cells (VICs). VICs exhibit diverse phenotypes, yet the specific subpopulation responsible for producing and regulating ela…
View article: Lectin-type oxidized LDL receptor-1 as a potential therapeutic target for cerebral cavernous malformations treatment
Lectin-type oxidized LDL receptor-1 as a potential therapeutic target for cerebral cavernous malformations treatment Open
Introduction Cerebral cavernous malformations (CCMs) are pathologic lesions comprised of clusters of thin-walled capillaries characterized by abnormal proliferation, angiogenesis, and bleeding secondary to somatic or germline mutations in …
View article: A 12‐month retrospective cohort study investigating the incidence and short‐term outcomes of e‐scooter injuries in regional Western Australia
A 12‐month retrospective cohort study investigating the incidence and short‐term outcomes of e‐scooter injuries in regional Western Australia Open
Background The rise in popularity of ride share e‐scooters has led to an increase in the number of e‐scooter injuries, with existing literature reporting increases in rates of admission by more than 350%. In April 2023, the Broome Shire si…
View article: Similarities and differences between brain and skin<i>GNAQ</i>p.R183Q driven capillary malformations
Similarities and differences between brain and skin<i>GNAQ</i>p.R183Q driven capillary malformations Open
Capillary malformations (CM) are congenital vascular irregularities of capillary and venous blood vessels that appear in the skin, leptomeninges of the brain, and the choroid of the eye in the disorder known as Sturge Weber Syndrome (SWS).…
View article: MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome
MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome Open
View article: An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma
An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma Open
Infantile hemangioma (IH) is the most common tumor in children and a paradigm for pathological vasculogenesis, angiogenesis and regression. Propranolol is the mainstay of treatment for IH. It inhibits hemangioma vessel formation via a β-ad…
View article: CD45 Is Sufficient to Initiate Endothelial-to-Mesenchymal Transition in Human Endothelial Cells—Brief Report
CD45 Is Sufficient to Initiate Endothelial-to-Mesenchymal Transition in Human Endothelial Cells—Brief Report Open
Background: Endothelial-to-mesenchymal transition (EndMT) is a dynamic process in which endothelial cells acquire mesenchymal properties and in turn contribute to tissue remodeling and growth. Previously, we found EndMT associated with mit…
View article: Long-term outcomes after using retrievable vena cava filters in major trauma patients with contraindications to prophylactic anticoagulation
Long-term outcomes after using retrievable vena cava filters in major trauma patients with contraindications to prophylactic anticoagulation Open
View article: S2 Heart Sound Detects Aortic Valve Calcification Independent of Hemodynamic Changes in Mice
S2 Heart Sound Detects Aortic Valve Calcification Independent of Hemodynamic Changes in Mice Open
Background Calcific aortic valve disease (CAVD) is often undiagnosed in asymptomatic patients, especially in underserved populations. Although artificial intelligence has improved murmur detection in auscultation exams, murmur manifestatio…
View article: Clinicians' perceptions of medical student teaching in a tertiary hospital
Clinicians' perceptions of medical student teaching in a tertiary hospital Open
Our contemporary survey identifies modifiable factors which should be targeted. If these factors are addressed successfully, it may allow the hospital and university medical school to harness the valuable resource of clinical teachers. Thi…
View article: Pigmentation Affects Elastic Fiber Patterning and Biomechanical Behavior of the Murine Aortic Valve
Pigmentation Affects Elastic Fiber Patterning and Biomechanical Behavior of the Murine Aortic Valve Open
The aortic valve (AoV) maintains unidirectional blood distribution from the left ventricle of the heart to the aorta for systemic circulation. The AoV leaflets rely on a precise extracellular matrix microarchitecture of collagen, elastin, …
View article: Acute kidney injury in patients hospitalized with COVID-19 in a Tertiary Care Hospital of Islamabad
Acute kidney injury in patients hospitalized with COVID-19 in a Tertiary Care Hospital of Islamabad Open
Objective: This study is conducted to find out prevalence, risk factor and outcome of acute kidney injury (AKI) in patients admitted with COVID-19 in Pakistani population. Study Design: Retrospective, Observational Study Place and Duration…
View article: Characterization of Aortic Valve Interstitial Cells Responsible for Elastogenesis
Characterization of Aortic Valve Interstitial Cells Responsible for Elastogenesis Open
The aortic valve (AoV) controls unidirectional blood distribution from the left ventricle of the heart to the aorta for systemic circulation. During the systolic and diastolic phases, AoV leaflets rely on a precise extracellular matrix (EC…
View article: Effectiveness of Laparoscopic Skills Workshop on Enhancing Knowledge and Skills of Surgical Residents and Its Comparison with DOPS (Direct Observation of Procedural Skills) Scores: Prospective Cohort Study
Effectiveness of Laparoscopic Skills Workshop on Enhancing Knowledge and Skills of Surgical Residents and Its Comparison with DOPS (Direct Observation of Procedural Skills) Scores: Prospective Cohort Study Open
View article: Communication—Detection of Salivary Cortisol Using Zinc Oxide and Copper Porphyrin Composite Using Electrodeposition and Plasma-Assisted Deposition
Communication—Detection of Salivary Cortisol Using Zinc Oxide and Copper Porphyrin Composite Using Electrodeposition and Plasma-Assisted Deposition Open
The reliability of two novel cortisol sensors was evaluated by detecting variations in salivary cortisol levels of college students. The diurnal salivary cortisol fluctuations in 50 college students were monitored, and the sensor results w…
View article: Laboratory-confirmed metformin-associated lactic acidosis
Laboratory-confirmed metformin-associated lactic acidosis Open
Metformin is considered the first line oral hypoglycaemic agent for the treatment of type 2 diabetes. We report three cases of prospectively identified laboratory confirmed metformin-associated lactic acidosis admitted to our intensive car…
View article: Stem Cell Cytoskeletal Responses to Pulsatile Flow in Heart Valve Tissue Engineering Studies
Stem Cell Cytoskeletal Responses to Pulsatile Flow in Heart Valve Tissue Engineering Studies Open
Heart valve replacement options remain exceedingly limited for pediatric patients because they cannot accommodate somatic growth. To overcome this shortcoming, heart valve tissue engineering using human bone marrow stem cells (HBMSCs) has …
View article: Univariate Cox regression analysis of patient demographics, co-morbidities, carotid artery disease characteristics and critical mechanical conditions in the symptomatic group.
Univariate Cox regression analysis of patient demographics, co-morbidities, carotid artery disease characteristics and critical mechanical conditions in the symptomatic group. Open
Univariate Cox regression analysis of patient demographics, co-morbidities, carotid artery disease characteristics and critical mechanical conditions in the symptomatic group.