Explanipedia

International Trends in Opioid Prescribing by Age and Sex from 2001 to 2019: An Observational Study Using Population-Based Databases from 18 Countries and One Special Administrative Region Open

Adrienne Y. L. Chan, Shahram Bahmanyar, Kebede Beyene, Greta Bushnell, Bruce Carleton , et al. · 2025

Opioid prescribing remains unbalanced across geographical regions; however, results suggest a tendency to convergence across countries/regions. Differences in opioid prescribing by sex and age were identified.

Platelet response to romiplostim amongst patients with newly diagnosed, persistent, and chronic immune thrombocytopenia in routine clinical practice in Denmark, Sweden, and Norway Open

Christian Fynbo Christiansen, Nickolaj Risbo, Waleed Ghanima, Marie Linder, Shahram Bahmanyar , et al. · 2024

Summary Patient characteristics and platelet responses at romiplostim initiation according to the duration of immune thrombocytopenia (ITP) are poorly understood. Amongst romiplostim‐exposed adults with ITP lasting ≥6 months during 2009–20…

Validation of safety outcomes in routinely collected data: Lessons learned from a multinational postapproval safety study Open

Patrick J. Arena, Kui Huang, Lukas Löfling, Shahram Bahmanyar, Jingping Mo , et al. · 2022

A national Swedish case-control study investigating incidence and factors associated with idiopathic intracranial hypertension Open

Anna Sundholm, Sarah Burkill, Elisabet Waldenlind, Shahram Bahmanyar, A Ingela M Nilsson Remahl · 2021

Objective To study the incidence of idiopathic intracranial hypertension in Sweden and to explore whether previously proposed risk factors are associated with idiopathic intracranial hypertension by investigating the odds of exposure one y…

Risk factors of hospitalisation for thrombosis in adults with primary immune thrombocytopenia, including disease‐specific treatments: a French nationwide cohort study Open

Margaux Lafaurie, Julien Maquet, Bérangère Baricault, Charlotta Ekstrand, Christian Fynbo Christiansen , et al. · 2021

Summary We aimed to assess the risk factors of venous thrombosis (VT) and arterial thrombosis (AT) in adults with primary immune thrombocytopenia (ITP), particularly in relation to treatments. The population comprised all incident primary …

Cardiovascular Risk in Users of Mirabegron Compared with Users of Antimuscarinic Treatments for Overactive Bladder: Findings from a Non-Interventional, Multinational, Cohort Study Open

Veena Hoffman, Jesper Hallas, Marie Linder, Andrea V. Margulis, Brandon T. Suehs , et al. · 2021

This large, multinational study found no higher risk of MACE, AMI, stroke, CV mortality or all-cause mortality among users of mirabegron relative to users of antimuscarinics.

Predictors for and outcomes after bone marrow biopsy in Scandinavian patients with chronic immune thrombocytopenia Open

Madeleine A. Gotschalck, Mette Nørgaard, Nickolaj Risbo, Christian Fynbo Christiansen, Shahram Bahmanyar , et al. · 2021

Objectives To examine predictors for bone marrow biopsy (BMB) and the outcome following BMB in patients with chronic immune thrombocytopenia (cITP). Methods We identified patients diagnosed with cITP during 2009‐2017 and obtained informati…

Antibiotic use prior to a lung cancer diagnosis: a population-based study Open

Lukas Löfling, Shahram Bahmanyar, Helle Kieler, Mats Lambe, Gunnar Wagenius · 2021

Aim To examine patterns of recent pre-diagnostic fillings of antibiotics as an indicator of early symptoms of lung cancer. Methods Individuals diagnosed with lung cancer (cases) in 2009–2016 were identified in the Swedish National Lung Can…

A study of cancer occurrence in users of mirabegron and antimuscarinic treatments for overactive bladder Open

Kelesitse Phiri, Jesper Hallas, Marie Linder, Andrea V. Margulis, Brandon T. Suehs , et al. · 2021

The results suggest no association between mirabegron use and risk of cancer, compared with antimuscarinic medications, in either men or women. Registration: EU PAS Register Number: EUPAS16088.

Outcomes in patients with lung cancer treated with crizotinib and erlotinib in routine clinical practice: A post‐authorization safety cohort study conducted in Europe and in the United States Open

Véra Ehrenstein, Kui Huang, Johnny Kahlert, Shahram Bahmanyar, Pär Karlsson , et al. · 2021

Purpose We examined safety outcomes of interest (SOI) and overall survival (OS) among lung cancer patients initiating crizotinib and erlotinib in routine clinical practice. Methods This descriptive cohort study used routinely collected hea…

A study of cancer occurrence in users of mirabegron and antimuscarinic treatments for overactive bladder Open

Kelesitse Phiri, Jesper Hallas, Marie Linder, Andrea V. Margulis, Brandon T. Suehs , et al. · 2021

This post-authorization safety study (EU PAS Register Number: EUPAS16088) was designed to compare the incidence of cancer outcomes in patients treated with mirabegron versus antimuscarinic medications. Cohorts of mirabegron initiators duri…

Temporal trends in lung cancer survival: a population-based study Open

Lukas Löfling, Shahram Bahmanyar, Helle Kieler, Mats Lambe, Gunnar Wagenius · 2021

Lung cancer is the number one cancer-related cause of death in Sweden and worldwide. In most countries, five-year survival estimates vary between 10% and 20% with evidence of improved survival over time. Over the last decades, the manageme…

Prevalence of adverse pregnancy outcomes after exposure to interferon beta prior to or during pregnancy in women with MS: Stratification by maternal and newborn characteristics in a register-based cohort study in Finland and Sweden Open

Marta Korjagina, Katja M. Hakkarainen, Sarah Burkill, Yvonne Geissbühler, Meritxell Sabidó , et al. · 2020

Cancer risk in patients with primary immune thrombocytopenia – A Swedish nationwide register study Open

Charlotta Ekstrand, Shahram Bahmanyar, Honar Cherif, Helle Kieler, Marie Linder · 2020

The DQB1*03:02 Genotype and Treatment for Pain in People With and Without Multiple Sclerosis Open

Sarah Burkill, Kelsi A Smith, Pernilla Stridh, Ingrid Kockum, Jan Hillert , et al. · 2020

Murine models have demonstrated that the major histocompatibility complex (MHC) is associated with pain-like behavior in peripheral nerve injury, however, the same association has not been shown when considering injury to the central nervo…

Higher body mass index at ages 16 to 20 years is associated with increased risk of a multiple sclerosis diagnosis in subsequent adulthood among men Open

Yin Xu, Ayako Hiyoshi, Judith S. Brand, Kelsi A Smith, Shahram Bahmanyar , et al. · 2020

Background: Evidence for the association between body mass index (BMI) and multiple sclerosis (MS) among men remains mixed. Objective and methods: Swedish military conscription and other registers identified MS after age of 20 years and BM…

Hospital diagnosed pneumonia before age 20 years and multiple sclerosis risk Open

Kelsi A Smith, Ayako Hiyoshi, Sarah Burkill, Shahram Bahmanyar, Johan Öckinger , et al. · 2020

Introduction Respiratory inflammation has been proposed as a risk factor for MS. This study aims to determine if hospital-diagnosed pneumonia in adolescence (before age 20 years) is associated with subsequent multiple sclerosis (MS). Metho…

Infectious and inflammatory disorders might increase the risk of developing idiopathic intracranial hypertension – a national case-control study Open

Anna Sundholm, Sarah Burkill, Elisabet Waldenlind, Shahram Bahmanyar, A Ingela M Nilsson Remahl · 2020

Objective To investigate whether conditions causing inflammatory activation are associated with increased risk of idiopathic intracranial hypertension. Methods All newly diagnosed idiopathic intracranial hypertension patients (cases) in Sw…

Comorbid disease burden among MS patients 1968–2012: A Swedish register–based cohort study Open

Kelsi A Smith, Sarah Burkill, Ayako Hiyoshi, Tomas Olsson, Shahram Bahmanyar , et al. · 2020

Background: People with multiple sclerosis (pwMS) have increased comorbid disease (CMD) risk. Most previous studies have not considered overall CMD burden. Objective: To describe lifetime CMD burden among pwMS. Methods: PwMS identified usi…

Comorbid disease burden among MS patients 1968–2012: A Swedish register–based cohort study Open

Kelsi A Smith, Sarah Burkill, Ayako Hiyoshi, Tomas Olsson, Shahram Bahmanyar , et al. · 2020

Background:People with multiple sclerosis (pwMS) have increased comorbid disease (CMD) risk. Most previous studies have not considered overall CMD burden.Objective:To describe lifetime CMD burden among pwMS.Methods:PwMS identified using Sw…

Pregnancy outcomes after exposure to interferon beta: a register-based cohort study among women with MS in Finland and Sweden Open

Katja M. Hakkarainen, Rosa Juuti, Sarah Burkill, Yvonne Geissbühler, Meritxell Sabidó , et al. · 2020

Background Our aim was to estimate and compare the prevalence of adverse pregnancy outcomes among pregnant women with multiple sclerosis (MS) exposed to interferon beta (IFNB) and among women with MS unexposed to any MS disease-modifying d…

sj-pdf-1-cep-10.1177_0333102420928079 - Supplemental material for Infectious and inflammatory disorders might increase the risk of developing idiopathic intracranial hypertension – a national case-control study Open

Anna Sundholm, Sarah Burkill, Elisabet Waldenlind, Shahram Bahmanyar, A Ingela M Nilsson Remahl · 2020

Supplemental material, sj-pdf-1-cep-10.1177_0333102420928079 for Infectious and inflammatory disorders might increase the risk of developing idiopathic intracranial hypertension – a national case-control study by Anna Sundholm, Sarah Burki…

The association between exposure to interferon-beta during pregnancy and birth measurements in offspring of women with multiple sclerosis Open

Sarah Burkill, Pia Vattulainen, Yvonne Geissbuehler, Meritxell Sabidó Espin, Catrinel Popescu , et al. · 2019

This study provides evidence that exposure to IFN-beta during pregnancy does not influence birth weight, length, or head circumference.

Methods for constructing treatment episodes and impact on exposure-outcome associations Open

Laura Pazzagli, Lena Brandt, Marie Linder, David T. Myers, Panagiotis Mavros , et al. · 2019

Exposure to risperidone versus other antipsychotics and risk of osteoporosis‐related fractures: a population‐based study Open

Eric Clapham, Robert Bodén, Johan Reutfors, Tobias Svensson, Darmendra Ramcharran , et al. · 2019

Objective Antipsychotics may increase serum prolactin, which has particularly been observed with risperidone. Further, hyperprolactinemia has been linked to osteoporosis‐related fractures. Therefore, we investigated fracture risk in a nati…

Chronic immune thrombocytopenia in Denmark, Sweden and Norway: The Nordic Country Patient Registry for Romiplostim Open

Christian Fynbo Christiansen, Shahram Bahmanyar, Waleed Ghanima, Nickolaj Risbo, Charlotta Ekstrand , et al. · 2019

Clinical characteristics and survival in non-small cell lung cancer patients by smoking history: a population-based cohort study Open

Lukas Löfling, Annette Karimi, Fredrik Sandin, Shahram Bahmanyar, Helle Kieler , et al. · 2019

Introduction: Approximately, 10-15% of lung cancer patients have never smoked. Previous epidemiological studies on non-tobacco associated lung cancer have been hampered by selected data from a small number of hospitals or limited nu…

Impact of risk factors on the occurrence of arterial thrombosis and venous thromboembolism in adults with primary immune thrombocytopenia – Results from two nationwide cohorts Open

Charlotta Ekstrand, Marie Linder, Bérangère Baricault, Margaux Lafaurie, L. Sailler , et al. · 2019

The IR of AT and VTE were similar in France. Age and male sex remained the most important risk factors for AT, age for VTE.

Cardiovascular and bleeding outcomes in a population‐based cohort of patients with chronic immune thrombocytopenia Open

Kasper Adelborg, Nickolaj Risbo Kristensen, Mette Nørgaard, Shahram Bahmanyar, Waleed Ghanima , et al. · 2019

Routine clinical care for chronic immune thrombocytopenia purpura in Denmark, 2009–2015 Open

Anne Gulbech Ording, Nickolaj Risbo Kristensen, Henrik Frederiksen, Naufil Alam, Shahram Bahmanyar , et al. · 2019

Objectives: To describe routine treatment and clinical characteristics of patients with chronic ITP (cITP).Methods: We used data from Danish nationwide registers and medical records to examine routine clinical care, including…

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