Explanipedia

What happens to patients awaiting urgent transplantation for refractory electrical storm when they are not transplanted? Open

Miloud Cherbi, Léa Benabou, Maxime Faure, Matteo Pozzi, Estelle Gandjbakhch , et al. · 2024

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Incidence and determinants of non-radial vascular approach for coronary angiography among heart transplant recipients Open

Niki Procopi, Paul Guedeney, Michel Zeitouni, Mathieu Kerneïs, Olivier Barthélémy , et al. · 2023

Background Repeated coronary angiograms may be required among heart transplant (HT) recipients to detect coronary allograft vasculopathy (CAV), exposing to higher risk of non-radial vascular approach over time. Objective To describe the in…

Sudden cardiac death after heart transplantation: a population-based study Open

Guillaume Bonnet, Guillaume Coutance, Olivier Aubert, Victor Waldmann, Marc Raynaud , et al. · 2023

Aims The epidemiology of sudden cardiac death (SCD) after heart transplantation (HTx) remains imprecisely described. We aimed to assess the incidence and determinants of SCD in a large cohort of HTx recipients, compared with the general po…

Association between vasoactive–inotropic score, morbidity and mortality after heart transplantation Open

Joanna Tohmé, Mickaël Lescroart, Jérémie Guillemin, Pascal Orer, Pauline Dureau , et al. · 2023

OBJECTIVES The aim of this study was to evaluate the association between vasoactive–inotropic score (VIS), calculated in the 24 h after heart transplantation, and post-transplant mortality and morbidity. METHODS This was an observational s…

Severity of SARS-CoV-2 Omicron variant infection in heart transplant recipients Open

Fanny Hazan, Constance Verdonk, Guillaume Coutance, Valentine Marie Ferré, Stéphane Marot , et al. · 2023

Clinical Prediction Model for Antibody-Mediated Rejection: A Strategy to Minimize Surveillance Endomyocardial Biopsies After Heart Transplantation Open

Guillaume Coutance, E. Kransdorf, Olivier Aubert, Guillaume Bonnet, Daniel Yoo , et al. · 2022

Background: In heart transplantation, antibody-mediated rejection (AMR) is a major contributor to patient morbidity and mortality. Multiple routine endomyocardial biopsies (EMB) remain the gold standard to detect AMR, but this invasive pro…

Impact of Sex in the Efficacy of Perioperative Desensitization Procedures in Heart Transplantation: A Retrospective Cohort Study Open

Lee S. Nguyen, Joe‐Elie Salem, Marie-Cécile Bories, Guillaume Coutance, Julien Amour , et al. · 2021

Background Sensitized patients, i.e. recipients with preformed donor-specific HLA antibodies (pfDSA), are at high-risk of developing antibody-mediated rejections (AMR) and dying after heart transplantation (HTx). Perioperative desensitizat…

Poor Antibody Response After Two Doses of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine in Transplant Recipients Open

Alessandra Mazzola, Ève Todesco, Sarah Drouin, Fanny Hazan, Stéphane Marot , et al. · 2021

A low anti-spike antibody response of 28.6% was observed 28 days after BNT162b2 vaccine second dose among 133 solid organ transplant recipients without previous coronavirus disease 2019 (COVID-19). No serious adverse events were recorded. …

Death Rate in Heart Transplant Recipients during the COVID-19 Outbreak in France Open

Camille Legeai, Carine Jasseron, C. Cantrelle, Shaïda Varnous, Marylou Para , et al. · 2021

Clinical manifestations and outcomes of coronavirus disease‐19 in heart transplant recipients: a multicentre case series with a systematic review and meta‐analysis Open

Camille Granger, Paul Guedeney, Camille Arnaud, Soulef Guendouz, Claire Cimadevilla , et al. · 2021

Available data on clinical presentation and mortality of coronavirus disease-2019 (COVID-19) in heart transplant (HT) recipients remain limited. We report a case series of laboratory-confirmed COVID-19 in 39 HT recipients from 3 French hea…

Trajectories of Cardiac Allograft Vasculopathy After Heart Transplantation and association with mortality: a population-based study Open

Guillaume Bonnet, Guillaume Coutance, Jan Van Keer, Marc Raynaud, Olivier Aubert , et al. · 2020

Background Cardiac allograft vasculopathy (CAV) is a major contributor of heart transplant recipient's mortality. However, the associations between CAV trajectories and mortality remains poorly described. Purpose We aimed to identify the d…

Incidence of sudden cardiac death after heart transplantation Open

Guillaume Bonnet, Guillaume Coutance, Victor Waldmann, Olivier Aubert, Anouk Asselin , et al. · 2020

Background Sudden cardiac death (SCD) is a major contributor to the rate of mortality after heart transplantation. However, little is known about the incidence of SCD in heart recipients. Objective To assess the incidence of SCD after hear…

Identification and Characterization of Trajectories of Cardiac Allograft Vasculopathy After Heart Transplantation Open

Alexandre Loupy, Guillaume Coutance, Guillaume Bonnet, Jan Van Keer, Marc Raynaud , et al. · 2020

Background: Cardiac allograft vasculopathy (CAV) is a major contributor of heart transplant recipient mortality. Little is known about the prototypes of CAV trajectories at the population level. We aimed to identify the different evolution…

Quadritherapy vs standard tritherapy immunosuppressant regimen after heart transplantation: A propensity score–matched cohort analysis Open

Lee S. Nguyen, Gaspard Suc, Vissal David Kheav, Guillaume Coutance, Maryvonnick Carmagnat , et al. · 2020

After heart transplant, adding everolimus (EVL) to standard immunosuppressive regimen mostly relies on converting calcineurin inhibitors (CNIs) into EVL. The aim of this study was to describe the effects of combining low-dose EVL and CNIs …

Predictive risk factors for postoperative pneumonia after heart transplantation Open

Charles Vidal, Romain Pasqualotto, Arthur James, Pauline Dureau, Julie Rasata , et al. · 2020

Predictive risk factors for postoperative pneumonia after heart transplantation Open

Charles Vidal, Romain Pasqualotto, Arthur James, Pauline Dureau, Julie Rasata , et al. · 2019

Background: Pneumonia is a frequent complication in patients undergoing heart transplantation (HTx) that increases morbidity and mortality in this population. Nevertheless, the risk factors for postoperative pneumonia (POP) are still unkno…

Reverse transcriptase multiplex ligation-dependent probe amplification in endomyocardial biopsies for the diagnosis of cardiac allograft rejection Open

Nicolas Adam, Guillaume Coutance, Pierre‐Julien Viailly, Fanny Drieux, Philippe Ruminy , et al. · 2019

Predictive risk factors of postoperative pneumonia after heart transplantation Open

Charles Vidal, Romain Pasqualotto, Arthur James, Pauline Dureau, Julie Rasata , et al. · 2019

Background Pneumonia is a frequent complication in patients undergoing heart transplantation (HTx) which increases morbidity and mortality in this population. Nevertheless, risk factors of postoperative pneumonia (POP) are still unknown. T…

Favorable Outcome of an Exclusively Posttransplant Prophylactic Strategy After Heart Transplantation in Recipients With High Immunological Risk Open

Guillaume Coutance, Virginie D'orio, Lisa Belin, Nicolas Bréchot, Samir Saheb , et al. · 2018

Background. Management of the increasing number of sensitized heart transplant candidates has become a recurrent issue. Rather than using pretransplant desensitization therapies, we used a posttransplant prophylactic strategy. Our aim was …

Effect of recipient gender and donor-specific antibodies on antibody-mediated rejection after heart transplantation Open

Lee S. Nguyen, Guillaume Coutance, Joe‐Elie Salem, S. Ouldamar, Guillaume Lebreton , et al. · 2018

Gender-difference regarding antibody-mediated rejection (AMR) after heart transplantation has been described. However, no study accounted for the presence of preformed donor-specific antibodies (pfDSA), a known risk factor of AMR, more com…

3399Determinants and outcomes of cardiac allograft vasculopathy: major role of donor specific antibody Open

Guillaume Bonnet, Maud Racapé, M.C. Bories, Shaïda Varnous, Philippe Rouvier , et al. · 2018

Background: Neutrophils are able to release their nuclear content into extracellular space by formation of neutrophil extracellular traps (NETs).NETs neutralize pathogens, but have also been implicated in autoimmune and thrombotic diseases…

P4222Pre-heart transplantation ECMO support achieved favorable post-transplant outcomes in selected patients Open

Guillaume Coutance, Pascal Leprince, Pierre Demondion, Nelly Jacob, Lee S. Nguyen , et al. · 2018

Purpose: To evaluate the usefulness of T. cruzi parasitic load (PL) quantitation in EMB for the early detection of CDR affecting the allograft.Methods: CDR was diagnosed in 8 heart-transplanted, chagasic patients (T.cruzi parasites detecte…

N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene Open

Blanca Morales Rodríguez, Lara Khouzami, V. Decostre, Shaïda Varnous, Vanja Pekovic‐Vaughan , et al. · 2018

Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA cardiomyopathy) is an anatomic and pathologic condition associated with muscular and electrical dysfunction of the heart, often leading to heart failure-r…

Performance of existing risk scores around heart transplantation: validation study in a 4-year cohort Open

Lee S. Nguyen, Guillaume Coutance, S. Ouldamar, Noël Zahr, Nicolas Bréchot , et al. · 2018

Several risk scores exist to help identify best candidate recipients for heart transplantation (HTx). This study describes the performance of five heart failure risk scores and two post-HTx mortality risk scores in a French single-centre c…

Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience Open

Nadia Bouabdallaoui, Pierre Demondion, Sylvestre Maréchaux, Shaïda Varnous, Guillaume Lebreton , et al. · 2018

Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and s…

Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience Open

Nadia Bouabdallaoui, Pierre Demondion, Sylvestre Maréchaux, Shaïda Varnous, Guillaume Lebreton , et al. · 2018

Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment.

Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience Open

Nadia Bouabdallaoui, Pierre Demondion, Sylvestre Maréchaux, Shaïda Varnous, Guillaume Lebreton , et al. · 2018

Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and s…

Reply to the Editor—Rhythmologic Challenges Following Heart Transplantation Open

Mikaël Laredo, Shaïda Varnous, Pauline Balagny, Pascal Leprince, Françoise Hidden‐Lucet , et al. · 2017

P2084Multi-layer longitudinal strain for noninvasive diagnosis of coronary allograft vasculopathy in heart transplant recipients: a comparative study ultrasound versus angiography Open

Nicolas Bonnet, Mathieu Kerneïs, S. Ouldamar, Florent Huang, Florent Laveau , et al. · 2017

Management of end-stage heart failure patients with or without ventricular assist device: an observational comparison of clinical and economic outcomes† Open

Nadia Aïssaoui, Michiel Morshuis, Hassani Maoulida, Joe‐Elie Salem, Guillaume Lebreton , et al. · 2017

HT should remain the first option for end-stage heart failure patients, associated with improved outcomes and better cost-effectiveness profile. VAD devices represent an option when transplant is not possible or when patient presentation i…

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