Shailesh S. Chalikwar
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View article: Impact of two-step glidant mixing process on flow performance of coated curcumin - In vitro, in vivo investigation
Impact of two-step glidant mixing process on flow performance of coated curcumin - In vitro, in vivo investigation Open
Curcumin is a well-known phenolic compound obtained from Curcuma Longa L. It is used popularly as an antioxidant, anti-inflammatory, antispasmodic, antithrombotic, anticancer as well as immune-modulator. In the last couple of years, few st…
View article: A current era in pulsatile drug delivery system: Drug journey based on chronobiology
A current era in pulsatile drug delivery system: Drug journey based on chronobiology Open
Almost all biological processes in the human body are regulated by circadian rhythm, which results in drastically different biochemical and physiological conditions throughout a 24 h period. Hence, suitable drug delivery systems should be …
View article: Design and development of high-dose bioactive oil-loaded transdermal patch with the aid of natural waste as an adsorbent- optimization with SeDeM-SLA tool
Design and development of high-dose bioactive oil-loaded transdermal patch with the aid of natural waste as an adsorbent- optimization with SeDeM-SLA tool Open
Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that affects joints significantly. Its prevalence varies globally, with more impact on females than males. Presently it is treated using NSAIDs which unfortunately show significan…
View article: Extraction of rutin from tagetes erecta (Marigold) and preparation of peroral nano-suspension for effective antitussive/expectorant therapy
Extraction of rutin from tagetes erecta (Marigold) and preparation of peroral nano-suspension for effective antitussive/expectorant therapy Open
The present study narrates the extraction of rutin from Tagetes erecta (Marigold) via maceration followed by ultrasonication. The extracted rutin was further fabricated into nanoparticles by high-pressure homogenization (HPH) and assessed …
View article: Development and characterization of amphotericin B nanoemulsion-loaded mucoadhesive gel for treatment of vulvovaginal candidiasis
Development and characterization of amphotericin B nanoemulsion-loaded mucoadhesive gel for treatment of vulvovaginal candidiasis Open
Despite being recognized as the "gold standard" for treating azole-resistant vulvovaginal candidiasis, amphotericin B (AmB), an amphoteric molecule, has not been widely used due to serious issues with solubility and permeability. In light …
View article: A comprehensive review on complex generics
A comprehensive review on complex generics Open
Complex generic is a generic with multifaceted dynamic constituent, multifaceted preparation, multifaceted path of administration, or multifaceted medicine device mixture. For over three decades, generics have been a desirable and cost-eff…
View article: Progress and Development in Treatment of Covid – 19, and Vaccine development: A Review
Progress and Development in Treatment of Covid – 19, and Vaccine development: A Review Open
The entire world is facing a worst situation of pandemic ever. It’s been more than 18 months after the initial reports on Covid from China, and the pandemic is still going. As per the data available over the WHO website as of 23 June 2021,…
View article: Solid lipid nanoparticles: Influence of composition, fabrication methods and problems, in vitro drug release and intranasal administration provide to access olfactory bulb pathway for SLNs
Solid lipid nanoparticles: Influence of composition, fabrication methods and problems, in vitro drug release and intranasal administration provide to access olfactory bulb pathway for SLNs Open
Background: Solid lipid nanoparticles (SLN) have drawn increasing interest in recent years. These nanoparticles are formed from stable or solid lipid mixtures and then stabilized by emulsifiers. As nanoparticles, colloidal particles runnin…
View article: Solid lipid nanoparticles: Influence of composition, fabrication methods and problems, in vitro drug release and intranasal administration provide to access olfactory bulb pathway for SLNs
Solid lipid nanoparticles: Influence of composition, fabrication methods and problems, in vitro drug release and intranasal administration provide to access olfactory bulb pathway for SLNs Open
Background: Solid lipid nanoparticles (SLN) have drawn increasing interest in recent years. These nanoparticles are formed from stable or solid lipid mixtures and then stabilized by emulsifiers. As nanoparticles, colloidal particles runnin…
View article: A Concise Review Based on Analytical Method Development and Validation of Apremilast in Bulk and Marketed Dosage Form
A Concise Review Based on Analytical Method Development and Validation of Apremilast in Bulk and Marketed Dosage Form Open
Apremilast is used for treatment of psoriasis and psoriatic arthritis. It may also be beneficial for other inflammatory diseases relevant to the immune system. The drug functions as a selective enzyme phosphodiesterase 4 (PDE4) inhibitor a…
View article: Traditional and Advanced Flow Characterization Techniques: A Platform Review for Development of Solid Dosage Form
Traditional and Advanced Flow Characterization Techniques: A Platform Review for Development of Solid Dosage Form Open
Preformulation studies like storage, transfer, fluidisation, and compaction, are subject to the excellent flowability of the powder. It is often required for proper operational management and consistent design of industrial processes. Two …
View article: BREAST CANCER: RECENT REVIEW ON MICELLES AS NANO-CARRIERS FOR TREATMENT
BREAST CANCER: RECENT REVIEW ON MICELLES AS NANO-CARRIERS FOR TREATMENT Open
Present review gives a brief explanation about Breast Cancer, its causes, factors that cause breast cancer, diagnosis, treatment, etc. A brief description of Cancer, and its types is also mentioned in this paper. Breast cancer is the most …
View article: ANALYTICAL METHOD DEVELOPMENT AND VALIDATION: A REVIEW
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION: A REVIEW Open
The development of sound Analytical method is of supreme importance during the process of drug discovery, release to market and development, culminating in a marketing approval. The objective of this paper is to review the method developme…
View article: Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes
Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes Open
The present work endeavors fabrication of fast dissolving buccal film of clonidine hydrochloride by employing quality by design (QbD) based approach. The total nine formulations were prepared according to formulation by design helped by JM…
View article: CYCLODEXTRIN IN DRUG DELIVERY APPLICATION: A REVIEW
CYCLODEXTRIN IN DRUG DELIVERY APPLICATION: A REVIEW Open
The cyclodextrins have a wide range of applications in various areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most popular pharmaceutical application of cyclode…
View article: AN OVERVIEW ON ANALYTICAL PROFILE OF VARENICLINE
AN OVERVIEW ON ANALYTICAL PROFILE OF VARENICLINE Open
Varenicline is a medicinal agent used to treat smoking addiction. Varenicline is first permitted nicotinic receptor partial agonist. Varenicline is an orally administered α4 andβ2 nicotinic acetylcholine receptor partial agonist. The prese…
View article: Ocimum Sanctum- A Traditional Remedy and Ethno Medicinal Uses, A Concise Review
Ocimum Sanctum- A Traditional Remedy and Ethno Medicinal Uses, A Concise Review Open
Medicinal plants are major source of bioactive compounds and chemical structures that gives potential beneficial effects.Ocimum sanctum (Tulsi) belongs to the Lamiaceae family, cultivated around tropical and semitropical zone of India and …
View article: Exploring RP-HPLC Method for analysis of Axitinib in Bulk and in-house Tablets
Exploring RP-HPLC Method for analysis of Axitinib in Bulk and in-house Tablets Open
Axitinib is a tyrosine kinase Inhibiter. In a commenced analysis, a effortless and responsive high-performance liquid-chromatography method was developed and validated for the quantitative estimation of Axitinib in bulk and in-house tablet…
View article: Application of Area Under Curve Technique for UV-Spectrophotometric Determination of Luliconazole in Bulk and Pharmaceutical Formulation
Application of Area Under Curve Technique for UV-Spectrophotometric Determination of Luliconazole in Bulk and Pharmaceutical Formulation Open
A simple, rapid, accurate and economical UV-spectrophometric method has been developed for estimation of Luliconazole in bulk and formulation using area under curve (AUC) technique. The method applied was an area under curve (AUC) in which…